Characterizing ipsilateral thalamic diaschisis in symptomatic cerebrovascular steno-occlusive patients

Niftrik, Christiaan Hendrik Bas van; Sebök, Martina; Muscas, Giovanni; Piccirelli, Marco; Serra, Carlo; Krayenbühl, Niklaus; Pangalu, Athina; Bozinov, Oliver; Luft, Andreas R.; Stippich, Christoph; Regli, Luca; Fierstra, Jorn

doi:10.1177/0271678x19830532

Cited by 17 publications

(18 citation statements)

References 31 publications

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“…Traditionally, BOLD‐CVR has been used as a surrogate imaging marker for the remaining cerebrovascular reserve capacity 12 . Recently, however, we have also shown the capability of using BOLD‐CVR to detect diaschisis 3,5,13,14 . The principle of BOLD‐CVR to detect CCD arises out of the underlying physiology that BOLD‐fMRI signal primarily reflects changes in deoxyhemoglobin.…”

Section: Discussionmentioning

confidence: 99%

Crossed Cerebellar Diaschisis in Patients With Symptomatic Unilateral Anterior Circulation Stroke Is Associated With Hemodynamic Impairment in the IpsilateralMCATerritory

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Niftrik

Piccirelli

et al. 2020

Magnetic Resonance Imaging

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Background In patients with steno‐occlusive disease, recent findings suggest that hemodynamic alterations may also be associated with crossed cerebellar diaschisis (CCD) rather than a functional disruption alone. Purpose To use a quantitative multiparametric hemodynamic MRI to gain a better understanding of hemodynamic changes related to CCD in patients with unilateral anterior circulation stroke. Study Type Prospective cohort study. Population Twenty‐four patients (25 datasets) with symptomatic unilateral anterior circulation stroke. Field Strength/Sequence 3T/two sequences: single‐shot (echo‐planar imaging) EPI sequence and T2* gradient echo perfusion‐weighted imaging study. Assessment The presence of CCD was inferred from the cerebellar asymmetry index (CAI) of the blood oxygenation‐level dependent cerebrovascular reactivity (BOLD‐CVR) exam, which was calculated from the mean BOLD‐CVR and standard deviation of the CAI of the healthy control group. For all perfusion‐weighted (PW)‐MRI parameters, the cerebellar and middle cerebral artery (MCA) territory asymmetry indices were calculated. Statistical Tests Independent Student's t‐test to compare the variables from the CCD positive(+) and CCD negative(–) groups and analysis of covariance (ANCOVA) to statistically control the effect of covariates (infarct volume and time since ischemia onset). Results CCD was present in 33% of patients. In the MCA territory of the affected hemisphere, BOLD‐CVR was significantly more impaired in the CCD(+) group as compared to the CCD(–) group (mean BOLD‐CVR ± SD [%BOLD signal/ΔmmHgCO2]: –0.03 ± 0.12 vs. 0.11 ± 0.13, P < 0.05). Moreover, the mean transit time (MTT) (asymmetry index (%) CCD(+) vs. CCD(–): 28 ± 23 vs. 4 ± 11, P < 0.05) and time to peak (TTP) (10 ± 10 vs. 2 ± 5, P < 0.05) in the MCA territory of the affected hemisphere were significantly prolonged, while cerebral blood volume was, on average, increased in the CCD(+) group (25 ± 15 vs. 4 ± 19, P < 0.05). Data Conclusion Our findings show that, in patients with symptomatic unilateral anterior circulation stroke, CCD is associated with hemodynamic impairment in the ipsilateral MCA territory, which further supports the concept of a vascular component of CCD. Level of Evidence 3 Technical Efficacy Stage 3

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Section: Discussionmentioning

confidence: 99%

Crossed Cerebellar Diaschisis in Patients With Symptomatic Unilateral Anterior Circulation Stroke Is Associated With Hemodynamic Impairment in the IpsilateralMCATerritory

Sebök

Niftrik

Piccirelli

et al. 2020

Magnetic Resonance Imaging

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“…Semi-automated volumetric segmentation was done using Freesurfer 5.3.0 ( http://surfer.nmr.mgh.harvard.edu/fswiki/FreeSurferWiki ) (Fischl et al 2002 , 2004 ). The anatomical T1-weighted MPRAGE images were automatically segmented into different anatomical subregions according to the Destrieux atlas (file name: aparcþaseg2009s.mgz) (Destrieux et al 2010 ; Hendrik Bas van Niftrik et al 2020 ). Anatomical regions of interest (ROI) were derived from the subjects’ specific tissue parcellation.…”

Section: Methodsmentioning

confidence: 99%

Topographic volume-standardization atlas of the human brain

et al. 2021

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Specific anatomical patterns are seen in various diseases affecting the brain. Clinical studies on the topography of pathologies are often limited by the absence of a normalization of the prevalence of pathologies to the relative volume of the affected anatomical structures. A comprehensive reference on the relative volumes of clinically relevant anatomical structures serving for such a normalization, is currently lacking. The analyses are based on anatomical high-resolution three-dimensional T1-weighted magnetic resonance imaging data of 30 healthy Caucasian volunteers, including 14 females (mean age 37.79 years, SD 13.04) and 16 males (mean age 38.31 years, SD 16.91). Semi-automated anatomical segmentation was used, guided by a neuroanatomical parcellation algorithm differentiating 96 structures. Relative volumes were derived by normalizing parenchymal structures to the total individual encephalic volume and ventricular segments to the total individual ventricular volume. The present investigation provides the absolute and relative volumes of 96 anatomical parcellation units of the human encephalon. A larger absolute volume in males than in females is found for almost all parcellation units. While parenchymal structures display a trend towards decreasing volumes with increasing age, a significant inverse effect is seen with the ventricular system. The variances in volumes as well as the effects of gender and age are given for each structure before and after normalization. The provided atlas constitutes an anatomically detailed and comprehensive analysis of the absolute and relative volumes of the human encephalic structures using a clinically oriented parcellation algorithm. It is intended to serve as a reference for volume-standardization in clinical studies on the topographic prevalence of pathologies.

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“…Semi-automated volumetric segmentation was done using Freesurfer 5.3.0 (http://surfer.nmr.mgh.harvard.edu/fswiki/FreeSurferWiki)(Fischl et al 2002, 2004). The anatomical T1-weighted MPRAGE images were automatically segmented into different anatomical subregions according to the Destrieux atlas (file name: aparcþaseg2009s.mgz)(Destrieux et al 2010; Hendrik Bas van Niftrik et al 2020). Anatomical regions of interest (ROI) were derived from the subjects’ specific tissue parcellation.…”

Section: Methodsmentioning

confidence: 99%

Topographic volume-standardization atlas of the human brain

Akeret

Niftrik

Sebök

et al. 2021

Preprint

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Objective Specific anatomical patterns are seen in various diseases affecting the brain. Clinical studies on the topography of pathologies are often limited by the absence of a normalization of the prevalence of pathologies to the relative volume of the affected anatomical structures. A comprehensive reference on the relative volumes of clinically relevant anatomical structures serving for such a normalization, is currently lacking. Methods The analyses are based on anatomical high-resolution three-dimensional T1-weighted magnetic resonance imaging data of 30 healthy Caucasian volunteers, including 14 females (mean age 37.79 years, SD 13.04) and 16 males (mean age 38.31 years, SD 16.91). Semi-automated anatomical segmentation was used, guided by a neuroanatomical parcellation algorithm differentiating 96 structures. Relative volumes were derived by normalizing parenchymal structures to the total individual encephalic volume and ventricular segments to the total individual ventricular volume. Results The present investigation provides the absolute and relative volumes of 96 anatomical parcellation units of the human encephalon. A larger absolute volume in males than in females is found for almost all parcellation units. While parenchymal structures display a trend towards decreasing volumes with increasing age, a significant inverse effect is seen with the ventricular system. The variances in volumes as well as the effects of gender and age are given for each structure before and after normalization. Conclusion The provided atlas constitutes an anatomically detailed and comprehensive analysis of the absolute and relative volumes of the human encephalic structures using a clinically oriented parcellation algorithm. It is intended to serve as a reference for volume-standardization in clinical studies on the topographic prevalence of pathologies.

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Characterizing ipsilateral thalamic diaschisis in symptomatic cerebrovascular steno-occlusive patients

Cited by 17 publications

References 31 publications

Crossed Cerebellar Diaschisis in Patients With Symptomatic Unilateral Anterior Circulation Stroke Is Associated With Hemodynamic Impairment in the IpsilateralMCATerritory

Crossed Cerebellar Diaschisis in Patients With Symptomatic Unilateral Anterior Circulation Stroke Is Associated With Hemodynamic Impairment in the IpsilateralMCATerritory

Topographic volume-standardization atlas of the human brain

Topographic volume-standardization atlas of the human brain

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