Characterizing Disease Features and Other Medical Diagnoses in Patients With Pityriasis Rubra Pilaris

Abstract

Pityriasis rubra pilaris (PRP) is a rare papulosquamous disorder that normally manifests with hyperkeratotic follicularbased papules, scaling erythematous plaques with areas of sparing, and palmoplantar keratoderma. 1 Considerable heterogeneity exists in the clinical features of PRP. Not all patients experience progression to erythroderma, and PRP is sometimes associated with a seronegative arthritis. 1,2 The prevalence of arthropathy in PRP or frequency of other known disease features such as alopecia or anhidrosis is unknown. 3,4 In addition, the prevalence of other medical diagnoses in patients with PRP is incompletely described.

The comprehensive impact of pityriasis rubra pilaris on physical symptoms, mental health, and activities of daily living: A mixed methods study

“…Anhidrosis was experienced by 79.6% of PRP patients in a prior survey study 7 and similarly in 84% of our participants. Anhidrosis was associated with erythroderma in PRP in another survey study 10 and has not been studied in other forms of erythroderma so it remains unclear if alterations to sweat production are specific to PRP.…”

“…PRP is a devastating skin disorder with a high burden of disease that affects multiple domains of physical and mental health and daily living. Patients with PRP have been shown to experience a lower quality of life than most other major skin disorders, including pemphigus, psoriasis, and eczema, 2 and have high rates of self‐reported depression 4,6,7 . Our aim in this mixed‐methods study was to explore the physical, mental health, and daily living impacts of PRP that may or may not be captured in other dermatology quality of life questionnaires, to help guide patients and their providers on how to best address the unique needs of people living with PRP.…”

“…Patients with PRP have been shown to experience a lower quality of life than most other major skin disorders, including pemphigus, psoriasis, and eczema, 2 and have high rates of selfreported depression. 4,6,7 Our aim in this mixed-methods study was to explore the physical, mental health, and daily living impacts of PRP that may or may not be captured in other dermatology quality of life questionnaires, to help guide patients and their providers on how to best address the unique needs of people living with PRP. Prior published case series describe in detail the morphologic and histopathologic presentation of PRP, but lack detailed information on the patient experience.…”

Patient and disease characteristics associated with psychiatric symptoms and impaired quality of life in pityriasis rubra pilaris

“…Dear Editor , Pityriasis rubra pilaris (PRP) is a rare papulosquamous condition that is comorbid with depression in 15–20% of cases 1–3 . A survey of 85 patients with PRP showed that PRP was associated with a worse quality of life (QoL) than other common dermatological conditions 4 .…”

Pityriasis rubra pilaris nach COVID-19-Impfung: Kausaler Zusammenhang oder Koinzidenz?

“…Lebensdekade manifestiert. Die Ätiologie ist unklar, wobei in einzelnen Fällen eine Triggerung durch Virusinfektionen (Hepatitis C, HIV), Impfungen oder Medikamente (u. a. Tyrosinkinase- und Checkpointinhibitoren), selten auch eine Assoziation mit Malignomen oder Hypothyreose beschrieben wurde [ 6 , 7 ]. Einzelne Berichte einer infektassoziierten PRP nach COVID-19-Infektion liegen vor [ 8 ].…”