Characterizing cerebellar activity during autobiographical memory retrieval: ALE and functional connectivity investigations

Addis, Donna Rose; Moloney, Eleanor E.J.; Tippett, Lynette J.; Roberts, Reece P.; Hach, Sylvia

doi:10.1016/j.neuropsychologia.2016.05.025

Cited by 36 publications

(20 citation statements)

References 97 publications

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“…These results are consistent with a large body of literature indicating that the cerebellum is part of wholebrain language networks (Price, 2012), is active during a variety of reading and language tasks (Stoodley and Schmahmann, 2009;Stoodley et al, 2012;Keren-Happuch et al, 2014;Mariën et al, 2014), and that the degree of rightward lateralization in the cerebellum is associated with better core language skills (Berl et al, 2014). Our findings also support and extend previous studies showing that right lobules VI/Crus I/II are engaged during many types of semantic processing (e.g., Xiang et al, 2003;Price, 2012;Addis et al, 2016;Lopes et al, 2016). Broadly speaking, our results add to a growing literature supporting a role for the cerebellum in language processing.…”

Section: Discussionsupporting

confidence: 92%

Cerebellar tDCS Modulates Neural Circuits during Semantic Prediction: A Combined tDCS-fMRI Study

D’Mello¹,

Turkeltaub

Stoodley³

2017

J. Neurosci.

121

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It has been proposed that the cerebellum acquires internal models of mental processes that enable prediction, allowing for the optimization of behavior. In language, semantic prediction speeds speech production and comprehension. Right cerebellar lobules VI and VII (including Crus I/II) are engaged during a variety of language processes and are functionally connected with cerebral cortical language networks. Further, right posterolateral cerebellar neuromodulation modifies behavior during predictive language processing. These data are consistent with a role for the cerebellum in semantic processing and semantic prediction. We combined transcranial direct current stimulation (tDCS) and fMRI to assess the behavioral and neural consequences of cerebellar tDCS during a sentence completion task. Task-based and resting-state fMRI data were acquired in healthy human adults (n ϭ 32; ϭ 23.1 years) both before and after 20 min of 1.5 mA anodal (n ϭ 18) or sham (n ϭ 14) tDCS applied to the right posterolateral cerebellum. In the sentence completion task, the first four words of the sentence modulated the predictability of the final target word. In some sentences, the preceding context strongly predicted the target word, whereas other sentences were nonpredictive. Completion of predictive sentences increased activation in right Crus I/II of the cerebellum. Relative to sham tDCS, anodal tDCS increased activation in right Crus I/II during semantic prediction and enhanced resting-state functional connectivity between hubs of the reading/language networks. These results are consistent with a role for the right posterolateral cerebellum beyond motor aspects of language, and suggest that cerebellar internal models of linguistic stimuli support semantic prediction.

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Section: Discussionsupporting

confidence: 92%

Cerebellar tDCS Modulates Neural Circuits during Semantic Prediction: A Combined tDCS-fMRI Study

D’Mello¹,

Turkeltaub

Stoodley³

2017

J. Neurosci.

121

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“…In line with this idea, functional neuroimaging studies have implicated the MTL, as well as frontal, parietal, and lateral temporal lobe regions in the retrieval of EAMs (Addis et al, 2016; Martinelli et al, 2013; Svoboda et al, 2006). Lesion studies have corroborated these neuroimaging findings and shown that EAM retrieval not only depends on the MTL (Cermak & O’Connor, 1983; Grilli & Verfaellie, 2014; Tulving, 1985) but also cortical regions of the episodic memory neural network (Berryhill et al, 2007; Bertossi et al, 2016).…”

mentioning

confidence: 80%

Evidence for Reduced Autobiographical Memory Episodic Specificity in Cognitively Normal Middle-Aged and Older Individuals at Increased Risk for Alzheimer’s Disease Dementia

Grilli

Wank

Bercel

et al. 2018

J Int Neuropsychol Soc

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Objective Alzheimer’s disease (AD) typically eludes clinical detection for years, if not decades. The identification of subtle cognitive decline associated with preclinical AD would not only advance understanding of the disease, but also provide clinical targets to assess preventative and early intervention treatments. Disrupted retrieval of detailed episodic autobiographical memories may be a sensitive indicator of subtle cognitive decline, because this type of memory taxes a core neural network affected by preclinical AD neuropathology. Method To begin to address this idea, we assessed the episodic specificity of autobiographical memories retrieved by cognitively normal middle-aged and older individuals who are carriers of the apolipoprotein E ε4 allele – a population at increased risk for subtle cognitive decline related to neuropathological risk factors for AD. We compared the ε4 carriers to non-carriers of ε4 similar in age, education, and gender. Results The ε4 carriers did not perform worse than the non-carriers on a comprehensive battery of neuropsychological tests. In contrast, as a group, the ε4 carriers generated autobiographical memories that were reduced in “internal” or episodic details relative to non-carriers. Conclusions These findings support the notion that reduced autobiographical episodic detail generation may be a marker of subtle cognitive decline associated with AD.

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“…The cerebellar hemispheres seem to be involved in a wide variety of cognitive tasks, including language processing (Desmond et al, 1998;Frings et al, 2006;McDermott et al, 2003;Tieleman et al, 2005), working memory (Desmond et al, 1997;Salmi et al, 2010), and other executive functions (Schall et al, 2003;Blackwood et al, 2004). Remarkably, the posterior cerebellar hemispheres are functionally connected to different areas within the prefrontal cortices (Addis et al, 2016;Habas et al, 2009;O'Reilly et al, 2009). Moreover, like the prefrontal cortices, the lateral regions of cerebellar hemispheres are the most recent parts to evolve (Ito, 2008).…”

Section: The Cerebellum's Role: Craving or Prediction?mentioning

confidence: 99%

“…Notably, functional magnetic resonance imaging studies, including resting-state and task-related functional connectivity confirm cerebellar relationships between the cortical and subcortical areas involved in addiction, and specifically in craving. Concretely, co-activations and functional connections between cerebellum and cortical structures, such as dorsolateral prefrontal cortex (Habas et al, 2009;Leutgeb et al, 2016;Moulton et al, 2011;Sang et al, 2012), orbitofrontal cortex (Addis et al, 2016;Habas et al, 2009;Leutgeb et al, 2016), anterior cingulate cortex (Addis et al, 2016;Moulton et al, 2011;Sang et al, 2012;Zeng et al, 2012), insula (Addis et al, 2016;Habas et al, 2009;Moulton et al, 2011;Sang et al, 2012), and inferior frontal gyrus (Addis et , 2016;Moulton et al, 2011;Tomasi and Volkow, 2011) have been reported. Other subcortical structures such as amygdala (Leutgeb et al, 2016;Sang et al, 2012;Zeng et al, 2012), hippocampus (Onuki et al, 2015;Sang et al, 2012;Zeng et al, 2012), ventral tegmental area (Carnell et al, 2014;Etkin et al, 2009;Kline et al, 2016;Kwon et al, 2014), dorsal striatum (Moulton et al, 2011;Sang et al, 2012;Tomasi and Volkow, 2011), and ventral striatum (Cauda et al, 2011;Cservenka et al, 2014;Koehler et al, 2013) also have demonstrated to be connected to the cerebellum.…”

Section: Introductionmentioning

confidence: 99%

The cerebellum in drug craving

Moreno-Rius

Miquel

2017

Drug and Alcohol Dependence

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Craving has been considered one of the core features of addiction. It can be defined as the urge or conscious desire to use a drug elicited by the drug itself, drug-associated cues or stressors. Craving plays a major role in relapse, even after prolonged periods of abstinence, as well as in the maintenance of drug seeking in non-abstinent addicts. The circuitry of craving includes medial parts of the prefrontal cortex, ventral striatal zones, ventral tegmental area, ventral pallidum, and limbic regions. Interestingly, the cerebellum shows reciprocal loops with many of these areas. The cerebellum has been linked traditionally to motor functions but increasing evidence indicates that this part of the brain is also involved in functions related to cognition, prediction, learning, and memory. Moreover, the functional neuroimaging studies that have addressed the study of craving in humans repeatedly demonstrate cerebellar activation when craving is elicited by the presentation of drug-related cues. However, the role of cerebellar activity in these craving episodes remains unknown. Therefore, the main goal of this review is to provide a brief update on craving studies and the traditional neural basis of this phenomenon, and then discuss and propose a hypothesis for the function of the cerebellum in craving episodes.

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Characterizing cerebellar activity during autobiographical memory retrieval: ALE and functional connectivity investigations

Cited by 36 publications

References 97 publications

Cerebellar tDCS Modulates Neural Circuits during Semantic Prediction: A Combined tDCS-fMRI Study

Cerebellar tDCS Modulates Neural Circuits during Semantic Prediction: A Combined tDCS-fMRI Study

Evidence for Reduced Autobiographical Memory Episodic Specificity in Cognitively Normal Middle-Aged and Older Individuals at Increased Risk for Alzheimer’s Disease Dementia

The cerebellum in drug craving

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