Characterizing biopersistence potential of the metabolite 5:3 fluorotelomer carboxylic acid after repeated oral exposure to the 6:2 fluorotelomer alcohol

Kabadi, Shruti V.; Fisher, Jeffrey W.; Doerge, Daniel R.; Mehta, Darshan; Aungst, Jason; Rice, Penelope A.

doi:10.1016/j.taap.2020.114878

Cited by 21 publications

(16 citation statements)

References 35 publications

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“…This finding points to a potential toxicity deriving from a short chain fluorosurfactant which supports two recent FDA-led studies regarding the toxicity of 6:2 fluorotelomer alcohol (FTOH), a short chain PFAS often used in food packaging and stain- and water-resistant textiles. In particular, the findings indicated the accumulation of 6:2 FTOH in the fat, liver, and plasma of rodents and adverse histopathological lesions in the animals’ kidneys 15,16 . All of the above highlight the necessity for proper regulation of AFFF composition.…”

Section: Discussionmentioning

confidence: 88%

Impact of Firefighting Aqueous Film-Forming Foams on Human Cell Proliferation and Cellular Mortality

Kafkoutsou

Yang

Zeynaloo

et al. 2022

Journal of Occupational &Amp; Environmental Medicine

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Section: Discussionmentioning

confidence: 88%

Impact of Firefighting Aqueous Film-Forming Foams on Human Cell Proliferation and Cellular Mortality

Kafkoutsou

Yang

Zeynaloo

et al. 2022

Journal of Occupational &Amp; Environmental Medicine

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“…Unlike other persistent organic pollutants, PFAAs are proteinophilic and tend to accumulate not in fat but in protein-rich tissues such as blood (Jones et al 2003 shorter-chain PFAAs, human serum elimination half-lives are on the order of days (Chang et al 2008;Nilsson et al 2010;Olsen et al 2007a). However, recent studies have indicated that some of the intermediate short-chain PFAS metabolites, such as 5:3 fluorotelomer carboxylic acid (FTCA), may biopersist and bioaccumulate (Kabadi et al 2018(Kabadi et al , 2020. Shorter-chain PFAAs also tend to accumulate in plants (Blaine et al 2013(Blaine et al , 2014Gobelius et al 2017;Lechner and Knapp 2011;Scher et al 2018;Stahl et al 2009;Yoo et al 2011), allowing them to enter terrestrial and aquatic food chains.…”

Section: Criteria For Regulating Pfas Under the California Code Of Rementioning

confidence: 99%

Regulating PFAS as a Chemical Class under the California Safer Consumer Products Program

Bǎlan

Mathrani

Guo

et al. 2021

Environ Health Perspect

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BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a group of manmade chemicals containing at least one fully fluorinated carbon atom. The widespread use, large number, and diverse chemical structures of PFAS pose challenges to any sufficiently protective regulation, emissions reduction, and remediation at contaminated sites. Regulating only a subset of PFAS has led to their replacement with other members of the class with similar hazards, that is, regrettable substitutions. Regulations that focus solely on perfluoroalkyl acids (PFAAs) are ineffective, given that nearly all other PFAS can generate PFAAs in the environment. OBJECTIVES: In this commentary, we present the rationale adopted by the State of California's Department of Toxic Substances Control (DTSC) for regulating PFAS as a class in certain consumer products. DISCUSSION: We at the California DTSC propose regulating certain consumer products if they contain any member of the class of PFAS because: a) all PFAS, or their degradation, reaction, or metabolism products, display at least one common hazard trait according to the California Code of Regulations, namely environmental persistence; and b) certain key PFAS that are the degradation, reaction or metabolism products, or impurities of nearly all other PFAS display additional hazard traits, including toxicity; are widespread in the environment, humans, and biota; and will continue to cause adverse impacts for as long as any PFAS continue to be used. Regulating PFAS as a class is thus logical, necessary, and forward-thinking. This technical position may be helpful to other regulatory agencies in comprehensively addressing this large class of chemicals with common hazard traits.

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“…PFAS can be also transferred to nursing infants or the fetus during pregnancy [ 14 , 15 ]. Some studies have suggested that PFAS do not undergo chemical reactions and are therefore not metabolized or biotransformed [ 16 , 17 ], while others have published reports based on the measurement of PFAS metabolites in vivo [ 18 ]. Rates of elimination vary across the type of compound and animal species with differences in age and sex, but humans normally eliminate these substances through urine [ 19 ].…”

Section: Toxicological Implications On Human Healthmentioning

confidence: 99%

Per- and Polyfluoroalkyl Substances (PFAS): Significance and Considerations within the Regulatory Framework of the USA

Langenbach

Wilson

2021

IJERPH

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Per- and polyfluoroalkyl substances (PFAS) are an emerging environmental crisis. Deemed forever chemicals, many congeners bioaccumulate and are incredibly persistent in the environment due to the presence of the strong carbon-fluorine covalent bonds. Notable PFAS compounds include perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and GenX. Robust toxicological knowledge exists for these substances, but regulatory decisions based on this knowledge has fallen behind. The United States Environmental Protection Agency (EPA) has addressed this issue with the PFAS Action Plan and EPA Council on PFAS, but the regulatory framework is severely lacking. Currently, no federal regulations or standards exist. Many occupational and non-occupational human cohorts exist that can lend knowledge on the environmental implications of PFAS and associated health effects. Occupationally, firefighters face significant exposure risks due to use of PFAS containing aqueous film-forming foams (AFFFs) and personal protective equipment contamination. Non-occupationally, wastewater discharge in North Carolina led to chronic and widespread residential exposure to GenX via drinking water contamination. This public health review seeks to convey the current and future significance of PFAS as an environmental contaminate, to lend considerations on regulatory frameworks within the USA, and to help guide and promote the need for future epidemiological studies in order to tackle this environmental emergency. While the PFAS Action Plan creates a scientific and regulatory foundation, it is important to take these lessons and apply them to future environmental health issues.

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Characterizing biopersistence potential of the metabolite 5:3 fluorotelomer carboxylic acid after repeated oral exposure to the 6:2 fluorotelomer alcohol

Cited by 21 publications

References 35 publications

Impact of Firefighting Aqueous Film-Forming Foams on Human Cell Proliferation and Cellular Mortality

Impact of Firefighting Aqueous Film-Forming Foams on Human Cell Proliferation and Cellular Mortality

Regulating PFAS as a Chemical Class under the California Safer Consumer Products Program

Per- and Polyfluoroalkyl Substances (PFAS): Significance and Considerations within the Regulatory Framework of the USA

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