Characterizing and modulating the mechanical properties of hydrogels from ventricular extracellular matrix

Fujita, Kyohei; Tuchida, Yuuki; Seki, Hiroki; Kosawada, Tadashi; Feng, Zhonggang; Shiraishi, Yasuyuki; Sato, Daisuke; Nakamura, Toshio; Umezu, Mitsuo

doi:10.1109/ascc.2015.7244661

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…167,195−197 Additionally, goat ventricles are utilized as a source for dECMbased material to fabricate a platform for embryonic stem cells. 198 Furthermore, bovine sources are used commonly to obtain demineralized and decellularized bone ECM in bone tissue engineering. 199 However, dECM from rodents and bovine are primarily used for research purposes and less for clinical applications.…”

Section: Potential Candidates To Procure Tissue-specific Ecmsmentioning

confidence: 99%

“…Rat tissues and organs are other potential ECM sources for obtaining adipose tissue, liver, heart, and skin. ,− Additionally, goat ventricles are utilized as a source for dECM-based material to fabricate a platform for embryonic stem cells . Furthermore, bovine sources are used commonly to obtain demineralized and decellularized bone ECM in bone tissue engineering .…”

Section: Decellularizationmentioning

confidence: 99%

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Decellularized Extracellular Matrix-based Bioinks for Engineering Tissue- and Organ-specific Microenvironments

et al. 2020

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Biomaterials-based biofabrication methods have gained much attention in recent years. Among them, 3D cell printing is a pioneering technology to facilitate the recapitulation of unique features of complex human tissues and organs with high process flexibility and versatility. Bioinks, combinations of printable hydrogel and cells, can be utilized to create 3D cell-printed constructs. The bioactive cues of bioinks directly trigger cells to induce tissue morphogenesis. Among the various printable hydrogels, the tissue- and organ-specific decellularized extracellular matrix (dECM) can exert synergistic effects in supporting various cells at any component by facilitating specific physiological properties. In this review, we aim to discuss a new paradigm of dECM-based bioinks able to recapitulate the inherent microenvironmental niche in 3D cell-printed constructs. This review can serve as a toolbox for biomedical engineers who want to understand the beneficial characteristics of the dECM-based bioinks and a basic set of fundamental criteria for printing functional human tissues and organs.

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Section: Potential Candidates To Procure Tissue-specific Ecmsmentioning

confidence: 99%

Section: Decellularizationmentioning

confidence: 99%

Decellularized Extracellular Matrix-based Bioinks for Engineering Tissue- and Organ-specific Microenvironments

et al. 2020

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“…Increases in cardiomyocytes and cardiac muscle were in fact observed in both rat and porcine MI models [58, 62]. As an alternative to porcine myocardium, rat [38, 64, 65], goat [66], and human myocardium [67-70] have been tested in vitro . Additionally, porcine small intestine submucosa (SIS) [71, 72] and human placenta [73] has been explored in vivo as a non-tissue-specific source as well as human and porcine pericardium as a potentially autologous tissue sources [34, 35, 74-76].…”

Section: Myocardiummentioning

confidence: 99%

Extracellular matrix hydrogel therapies: In vivo applications and development

2018

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“…(A detailed review is provided by Gilpin et al [14]). To date, porcine [15], goat [16], rodent [17,18], and human [19][20][21] hearts have been used to derive myocardial ECM for a variety of research purposes [22]. Among them, myocardial ECM derived from porcine hearts is the most advanced in the translational process, with a product now undergoing clinical trials for post-MI patients (identifier: NCT02305602) [23].…”

Section: Common Methods To Fabricate Scaffolds 21 Decellularized Tiss...mentioning

confidence: 99%

Recent Advances in Tissue-Engineered Cardiac Scaffolds—The Progress and Gap in Mimicking Native Myocardium Mechanical Behaviors

Baghersad

Kumar

Kipper

et al. 2023

JFB

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Heart failure is the leading cause of death in the US and worldwide. Despite modern therapy, challenges remain to rescue the damaged organ that contains cells with a very low proliferation rate after birth. Developments in tissue engineering and regeneration offer new tools to investigate the pathology of cardiac diseases and develop therapeutic strategies for heart failure patients. Tissue -engineered cardiac scaffolds should be designed to provide structural, biochemical, mechanical, and/or electrical properties similar to native myocardium tissues. This review primarily focuses on the mechanical behaviors of cardiac scaffolds and their significance in cardiac research. Specifically, we summarize the recent development of synthetic (including hydrogel) scaffolds that have achieved various types of mechanical behavior—nonlinear elasticity, anisotropy, and viscoelasticity—all of which are characteristic of the myocardium and heart valves. For each type of mechanical behavior, we review the current fabrication methods to enable the biomimetic mechanical behavior, the advantages and limitations of the existing scaffolds, and how the mechanical environment affects biological responses and/or treatment outcomes for cardiac diseases. Lastly, we discuss the remaining challenges in this field and suggestions for future directions to improve our understanding of mechanical control over cardiac function and inspire better regenerative therapies for myocardial restoration.

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Characterizing and modulating the mechanical properties of hydrogels from ventricular extracellular matrix

Cited by 4 publications

References 11 publications

Decellularized Extracellular Matrix-based Bioinks for Engineering Tissue- and Organ-specific Microenvironments

Decellularized Extracellular Matrix-based Bioinks for Engineering Tissue- and Organ-specific Microenvironments

Extracellular matrix hydrogel therapies: In vivo applications and development

Recent Advances in Tissue-Engineered Cardiac Scaffolds—The Progress and Gap in Mimicking Native Myocardium Mechanical Behaviors

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