The present study describes the estimation of particulate matter (cotton dust) with different sizes, i.e., PM 1.0 , PM 2.5 , PM 4.0 , and PM 10.0 渭m in smallscale weaving industry (power looms) situated in district Hafizabad, Punjab, Pakistan, and the assessment of health problems of workers associated with these pollutants. A significant difference was found in PM 1.0 , PM 2.5 , PM 4.0 , and PM 10.0 with reference to nine different sampling stations with p values <0.05. Multiple comparisons of particulate matter with respect to size, i.e. PM 1.0 , PM 2.5 , PM 4.0 , and PM 10.0 , depict that PM 1.0 differs significantly from PM 2.5 , PM 4.0 , and PM 10.0 , with p values <0.05 and that PM 2.5 differs significantly from PM 1.0 and PM 10.0 , with p values <0.05, whereas PM 2.5 differs nonsignificantly from PM 4.0 , with a p value >0.05 in defined sampling stations on an average basis. Majority of the workers were facing several diseases due to interaction with particulate matter (cotton dust) during working hours. Flue, cough, eye, and skin infections were the most common diseases among workers caused by particulate matter (cotton dust).