Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

“…Overall, sex differences were subtle, and it is important to note that women had larger confidence intervals than men, particularly at high CVD risk. Surprisingly, sex did not modify susceptibility to WMHs in the presence of CVD risk, despite our previous work ( Stickel et al, 2023 ) and others ( Sachdev et al, 2009 ) showing that women may be particularly vulnerable to higher WMH volumes with advancing age. Additionally, recent study suggests that even before older adulthood, cardiovascular disease risk is associated with cognitive declines among women more so than men ( Huo et al, 2022 ).…”

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

“…Overall, sex differences were subtle, and it is important to note that women had larger confidence intervals than men, particularly at high CVD risk. Surprisingly, sex did not modify susceptibility to WMHs in the presence of CVD risk, despite our previous work ( Stickel et al, 2023 ) and others ( Sachdev et al, 2009 ) showing that women may be particularly vulnerable to higher WMH volumes with advancing age. Additionally, recent study suggests that even before older adulthood, cardiovascular disease risk is associated with cognitive declines among women more so than men ( Huo et al, 2022 ).…”

Cardiovascular Risk Predicts White Matter Hyperintensities, Brain Atrophy and Treatment Resistance in Major Depressive Disorder: Role of Genetic Liability

“…Phenotypic CV risk is also associated with reduced total and grey matter volumes in our sample, again mirroring the results of a recent large UK biobank study [20], and of numerous other investigations [17,48,49]. Nonetheless, while again frequently reported, the association between cardiovascular health and brain volumes appears to be a complex one, with various pathophysiological mechanisms implicated [50].…”

Distribution of White Matter Hyperintensities across Arterial Territories in Neurodegenerative Diseases

“…Sex-specific differences in WMH burden were observed across several clinical categories (Table 2.1). Consistent with literature suggesting that men tend to experience greater cardiovascular risk factor-related differences in total brain volumes than women [172], men were found to have a higher WMH burden in the whole-brain (controlled for brain size via the use of a standardized brain space) and/or an arterial region across several categories (CU, MCI, MCI+V, FTD, PD). However, after controlling for total WMH burden (i.e., using the WMH ratio), women exhibited a higher ACA t WMH ratio in SCD and MCI (Table 2.2).…”

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

“…Overall, sex differences were subtle, and it is important to note that women had larger confidence intervals than men, particularly at high CVD risk. Surprisingly, sex did not modify susceptibility to WMHs in the presence of CVD risk, despite our previous work ( Stickel et al, 2023 ) and others ( Sachdev et al, 2009 ) showing that women may be particularly vulnerable to higher WMH volumes with advancing age. Additionally, recent study suggests that even before older adulthood, cardiovascular disease risk is associated with cognitive declines among women more so than men ( Huo et al, 2022 ).…”

Cardiovascular Risk Predicts White Matter Hyperintensities, Brain Atrophy and Treatment Resistance in Major Depressive Disorder: Role of Genetic Liability

“…Phenotypic CV risk is also associated with reduced total and grey matter volumes in our sample, again mirroring the results of a recent large UK biobank study [20], and of numerous other investigations [17,48,49]. Nonetheless, while again frequently reported, the association between cardiovascular health and brain volumes appears to be a complex one, with various pathophysiological mechanisms implicated [50].…”

Distribution of White Matter Hyperintensities across Arterial Territories in Neurodegenerative Diseases

“…Sex-specific differences in WMH burden were observed across several clinical categories (Table 2.1). Consistent with literature suggesting that men tend to experience greater cardiovascular risk factor-related differences in total brain volumes than women [172], men were found to have a higher WMH burden in the whole-brain (controlled for brain size via the use of a standardized brain space) and/or an arterial region across several categories (CU, MCI, MCI+V, FTD, PD). However, after controlling for total WMH burden (i.e., using the WMH ratio), women exhibited a higher ACA t WMH ratio in SCD and MCI (Table 2.2).…”

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

“…Overall, sex differences were subtle, and it is important to note that women had larger confidence intervals than men, particularly at high CVD risk. Surprisingly, sex did not modify susceptibility to WMHs in the presence of CVD risk, despite our previous work ( Stickel et al, 2023 ) and others ( Sachdev et al, 2009 ) showing that women may be particularly vulnerable to higher WMH volumes with advancing age. Additionally, recent study suggests that even before older adulthood, cardiovascular disease risk is associated with cognitive declines among women more so than men ( Huo et al, 2022 ).…”

Cardiovascular Risk Predicts White Matter Hyperintensities, Brain Atrophy and Treatment Resistance in Major Depressive Disorder: Role of Genetic Liability

“…Phenotypic CV risk is also associated with reduced total and grey matter volumes in our sample, again mirroring the results of a recent large UK biobank study [20], and of numerous other investigations [17,48,49]. Nonetheless, while again frequently reported, the association between cardiovascular health and brain volumes appears to be a complex one, with various pathophysiological mechanisms implicated [50].…”

Distribution of White Matter Hyperintensities across Arterial Territories in Neurodegenerative Diseases

“…Sex-specific differences in WMH burden were observed across several clinical categories (Table 2.1). Consistent with literature suggesting that men tend to experience greater cardiovascular risk factor-related differences in total brain volumes than women [172], men were found to have a higher WMH burden in the whole-brain (controlled for brain size via the use of a standardized brain space) and/or an arterial region across several categories (CU, MCI, MCI+V, FTD, PD). However, after controlling for total WMH burden (i.e., using the WMH ratio), women exhibited a higher ACA t WMH ratio in SCD and MCI (Table 2.2).…”