Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

Stickel, Ariana; Tarraf, Wassim; González, Kevin A.; Ivanovic, Vladamir; Paredes, Alejandra Morlett; Zeng, Donglin; Cai, Jianwen; Isasi, Carmen R.; Kaplan, Robert C.; Lipton, Richard B.; Daviglus, Martha L.; Testai, Fernando D.; Lamar, Melissa; Gallo, Linda C.; Talavera, Gregory A.; Gellman, Marc D.; Ramos, Alberto R.; González, Hector M.; DeCarli, Charles

doi:10.1016/j.neurobiolaging.2023.02.007

Cited by 5 publications

(9 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, sex differences were subtle, and it is important to note that women had larger confidence intervals than men, particularly at high CVD risk. Surprisingly, sex did not modify susceptibility to WMHs in the presence of CVD risk, despite our previous work ( Stickel et al, 2023 ) and others ( Sachdev et al, 2009 ) showing that women may be particularly vulnerable to higher WMH volumes with advancing age. Additionally, recent study suggests that even before older adulthood, cardiovascular disease risk is associated with cognitive declines among women more so than men ( Huo et al, 2022 ).…”

Section: Discussioncontrasting

confidence: 95%

“…The study included an unweighted total of 1,886 participants (weighted as 42% men and 58% women), aged 50–85 years, all of whom had completed MRI imaging and relevant image processing. Neuroimaging methods are described below and in our first report on age and sex associations with brain volumes ( Stickel et al, 2023 ).…”

Section: Methodsmentioning

confidence: 99%

“…All images were processed and analyzed using pipelines created at UC Davis’ Imaging of Dementia and Aging (IDeA) laboratory. These steps are detailed elsewhere ( Stickel et al, 2023 ). The presence of MRI infarction was determined from the size, location, and imaging characteristics of the lesion as previously described ( DeCarli et al, 2005 ).…”

Section: Methodsmentioning

confidence: 99%

“…Hispanic/Latino adults tend to have strokes at earlier ages compared to non-Hispanic/Latino white adults and may have higher prevalence, but this varies widely by age, sex, type of stroke, and heritage group (e.g., Mexican vs. Cuban heritage) ( Morgenstern et al, 1997 ; Uchino et al, 2004 ; Prabhakaran et al, 2008 ; Rodriguez et al, 2014 ; Tsao et al, 2022 ). Heritage group alone is associated with differences in CVD risk factors, self-reported stroke, and brain structure ( Daviglus et al, 2012 ; Stickel et al, 2023 ), but most existing studies of Hispanic/Latino brain aging sample almost exclusively from one or two heritage groups.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

Stickel,

Tarraf,

Gonzalez

et al. 2024

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

BackgroundCardiovascular disease (CVD) risk factors are highly prevalent among Hispanic/Latino adults, while the prevalence of MRI infarcts is not well-documented. We, therefore, sought to examine the relationships between CVD risk factors and infarcts with brain structure among Hispanic/Latino individuals.MethodsParticipants included 1,886 Hispanic/Latino adults (50–85 years) who underwent magnetic resonance imaging (MRI) as part of the Study of Latinos—Investigation of Neurocognitive Aging-MRI (SOL-INCA-MRI) study. CVD risk was measured approximately 10.5 years before MRI using the Framingham cardiovascular risk score, a measure of 10-year CVD risk (low (<10%), medium (10- < 20%), and high (≥20%)). MR infarcts were determined as present or absent. Outcomes included total brain, cerebral and lobar cortical gray matter, hippocampal, lateral ventricle, and total white matter hyperintensity (WMH) volumes. Linear regression models tested associations between CVD risk and infarct with MRI outcomes and for modifications by age and sex.ResultsSixty percent of participants were at medium or high CVD risk. Medium and high CVD risk were associated with lower total brain and frontal gray matter and higher WMH volumes compared to those with low CVD risk. High CVD risk was additionally associated with lower total cortical gray matter and parietal volumes and larger lateral ventricle volumes. Men tended to have greater CVDRF-related differences in total brain volumes than women. The association of CVD risk factors on total brain volumes increased with age, equal to an approximate 7-year increase in total brain aging among the high-CVD-risk group compared to the low-risk group. The presence of infarct(s) was associated with lower total brain volumes, which was equal to an approximate 5-year increase in brain aging compared to individuals without infarcts. Infarcts were also associated with smaller total cortical gray matter, frontal and parietal volumes, and larger lateral ventricle and WMH volumes.ConclusionThe high prevalence of CVD risk among Hispanic/Latino adults may be associated with accelerated brain aging.

show abstract

Section: Discussioncontrasting

confidence: 95%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

Stickel,

Tarraf,

Gonzalez

et al. 2024

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Kim et al., for example, found evidence of curvilinearity in parietal, frontal, and total gray matter for men but not women 34 . Previous SOL‐INCA MRI found that men, on average, have larger WMH volumes compared to women 52 . Although not statistically significant, the interaction model with WMHs had a low p value ( p < 0.10).…”

Section: Discussionmentioning

confidence: 93%

Sleep duration and brain MRI measures: Results from the SOL‐INCA MRI study

González,

Tarraf,

Stickel

et al. 2023

Alzheimer's & Dementia

Self Cite

View full text Add to dashboard Cite

INTRODUCTIONSleep duration has been associated with dementia and stroke. Few studies have evaluated sleep pattern–related outcomes of brain disease in diverse Hispanics/Latinos.METHODSThe SOL‐INCA (Study of Latinos‐Investigation of Neurocognitive Aging) magnetic resonance imaging (MRI) study recruited diverse Hispanics/Latinos (35–85 years) who underwent neuroimaging. The main exposure was self‐reported sleep duration. Our main outcomes were total and regional brain volumes.RESULTSThe final analytic sample included n = 2334 participants. Increased sleep was associated with smaller brain volume (βtotal_brain = −0.05, p < 0.01) and consistently so in the 50+ subpopulation even after adjusting for mild cognitive impairment status. Sleeping >9 hours was associated with smaller gray (βcombined_gray = −0.17, p < 0.05) and occipital matter volumes (βoccipital_gray = −0.18, p < 0.05).DISCUSSIONWe found that longer sleep duration was associated with lower total brain and gray matter volume among diverse Hispanics/Latinos across sex and background. These results reinforce the importance of sleep on brain aging in this understudied population.Highlights Longer sleep was linked to smaller total brain and gray matter volumes. Longer sleep duration was linked to larger white matter hyperintensities (WMHs) and smaller hippocampal volume in an obstructive sleep apnea (OSA) risk group. These associations were consistent across sex and Hispanic/Latino heritage groups.

show abstract

Neurocognitive profiles are associated with subsequent brain integrity in a sample of Hispanics/Latinos: Findings from the SOL‐INCA‐MRI study (HCHS/SOL)

Sapkota,

Maillard,

Stickel

et al. 2024

Alz & Dem Diag Ass & Dis Mo

View full text Add to dashboard Cite

The Hispanic/Latino population is one of the largest and most diverse ethnoracial groups in the United States at high risk for dementia. We examined cognitive constructs and associations with subsequent hippocampal volume (HV) and white matter hyperintensity volume (WMHV). Participants were from the Hispanic Community Health Study/Study of Latinos–Magnetic Resonance Imaging Study (n = 2029). We examined confirmatory factor analysis and longitudinal invariance using neurocognitive scores at Visits 1 (2008–2011) and 2 (2014–2018) and path analyses. We obtained a longitudinally invariant two‐factor episodic memory (EM) and working memory (WM) construct. Lower EM profile at both visits was associated with greater WMHV and smaller HV at Visit 2. Lower WM profile at both visits was associated with larger WMHV and smaller HV at Visit 2. Neurocognitive profiles were associated with subsequent neurodegeneration in a sample of Hispanics/Latinos. Identifying neurocognitive risk profiles may lead to early detection and intervention, and significantly impact the course of neurodegeneration.Highlights Cognitive profiles predict brain integrity up to 10 years later. We observed two‐factor latent memory constructs and longitudinal invariance. These findings were observed in a Hispanic/Latino cohort.

show abstract

Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

Cited by 5 publications

References 61 publications

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

Sleep duration and brain MRI measures: Results from the SOL‐INCA MRI study

Neurocognitive profiles are associated with subsequent brain integrity in a sample of Hispanics/Latinos: Findings from the SOL‐INCA‐MRI study (HCHS/SOL)

Contact Info

Product

Resources

About