Characterizing adolescents with heavy menstrual bleeding and generalized joint hypermobility

Kendel, Nicole E.; Haamid, Fareeda W.; Christian‐Rancy, Myra; O’Brien, Sarah H.

doi:10.1002/pbc.27675

Cited by 13 publications

(17 citation statements)

References 15 publications

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“…Definitions. Heavy menstrual bleeding was defined by menstrual duration ≥ 7 days with a sensation of "gushing" or "flooding" or bleeding through a pad or tampon in ≤ 2 hours (8,9).…”

Section: Methods (Also See Online Supplement)mentioning

confidence: 99%

Bleeding disorders in adolescents with heavy menstrual bleeding in a multicenter prospective US cohort

Zia

Jain²,

Kouides

et al. 2019

Haematologica

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“…Definitions. Heavy menstrual bleeding was defined by menstrual duration ≥ 7 days with a sensation of "gushing" or "flooding" or bleeding through a pad or tampon in ≤ 2 hours (8,9).…”

Section: Methods (Also See Online Supplement)mentioning

confidence: 99%

Bleeding disorders in adolescents with heavy menstrual bleeding in a multicenter prospective US cohort

Zia

Jain²,

Kouides

et al. 2019

Haematologica

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“…These patients can have mucocutaneous bleeding, such as HMB, bruising, and gastrointestinal bleeding, as well as a history of joint pain and instability. 39 On physical examination, patients can have striae, signs of poor wound healing, and skin laxity. A bleeding workup may be normal, although some patients with these disorders can have abnormal PA.…”

Section: Connective Tissue Disordersmentioning

confidence: 99%

Diagnosis and Management of Heavy Menstrual Bleeding and Bleeding Disorders in Adolescents

Borzutzky

Jaffray

2020

JAMA Pediatr

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IMPORTANCE Heavy menstrual bleeding is a common cause of anemia and reduced quality of life in adolescents. There is a higher prevalence of bleeding disorders in girls with heavy menstrual bleeding than in the general population. Pediatricians should be comfortable with the initial evaluation of heavy menstrual bleeding and the indications for referral to subspecialty care.OBSERVATIONS The most common cause of heavy menstrual bleeding in adolescents is ovulatory dysfunction, followed by coagulopathies. The most common inherited bleeding disorder is von Willebrand disease, and its incidence in adolescents with heavy menstrual bleeding is high. Distinguishing the etiology of heavy menstrual bleeding will guide treatment, which can include hemostatic medications, hormonal agents, or a combination of both. Among hormonal agents, the 52-mg levonogestrel intrauterine device has been shown to be superior in its effect on heavy menstrual bleeding and is safe and effective in adolescents with bleeding disorders.CONCLUSIONS AND RELEVANCE Anemia, need for transfusion of blood products, and hospitalization may be avoided with prompt recognition, diagnosis, and treatment of heavy menstrual bleeding, especially when in the setting of bleeding disorders. Safe and effective treatment methods are available and can greatly improve quality of life for affected adolescents. A multidisciplinary approach to the treatment of girls with bleeding disorders and history of heavy menstrual bleeding is optimal.

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“…A hypermobility syndrome was diagnosed with Beighton Score alone and when the score was 5 or more. 21,22…”

Section: Bleeding Disordermentioning

confidence: 99%

Iron deficiency and fatigue among adolescents with bleeding disorders

et al. 2021

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Iron deficiency anemia is associated with heavy menstrual bleeding (HMB) and, by extension, a bleeding disorder (BD). It is unknown if iron deficiency without anemia is associated with a BD in adolescents. Moreover, the threshold of ferritin associated with fatigue in adolescents with HMB is unclear. In this multicenter study, we enrolled adolescents with HMB without BD. Participants underwent BD and anemia work-up in Young Women's Hematology Clinics and completed the Peds QL™ fatigue scale. BDs were defined as von Willebrand Disease, platelet function defect, clotting factor deficiencies, and hypermobility syndrome. Two hundred and fifty consecutive adolescents were enrolled, of whom 196 met eligibility criteria. Overall, 43% (95% confidence interval: 36%-50%) were diagnosed with BD. A total of 61% (n = 119) had serum ferritin levels < 15 ng/mL, 23.5% (n = 46) had iron deficiency only, and 37% (n = 73) had iron deficiency anemia. Low ferritin or ferritin dichoto-

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Characterizing adolescents with heavy menstrual bleeding and generalized joint hypermobility

Cited by 13 publications

References 15 publications

Bleeding disorders in adolescents with heavy menstrual bleeding in a multicenter prospective US cohort

Bleeding disorders in adolescents with heavy menstrual bleeding in a multicenter prospective US cohort

Diagnosis and Management of Heavy Menstrual Bleeding and Bleeding Disorders in Adolescents

Iron deficiency and fatigue among adolescents with bleeding disorders

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