Abstract:NuA4 is an essential lysine acetyltransferase (KAT) in yeast and is homologous to Tip60, a disease relevant protein complex in mammalian cells. As our lab and others have recently identified a novel role for NuA4 in lipid regulation, we performed a global lipidomic analysis. We determined that two mutants of NuA4, a temperature sensitive mutant of the catalytic subunit (esa1‐ts) and deletion of the non‐essential scaffolding subunit (eaf1Δ), have an increase in the relative abundance of ergosteryl esters, the y… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.