Characterizations of magnetotactic bacteria conjugated versus unconjugated with carboxylate-Functionalized superparamagnetic iron oxide nanoparticles for tumor targeting purposes

Majedi, Yasamin; Loghin, Dumitru; Mohammadi, Mohammad

doi:10.1109/marss.2017.8001938

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…Thus, by altering the magnetic field, as shown in [ 240 ], it may be possible to control the drug delivery process and move them to the tumor. Some authors [ 242 , 243 , 244 ] within the framework of this concept call these bacteria specialized nanorobots ( Figure 22 ).…”

Section: Biogenic Nanoparticlesmentioning

confidence: 99%

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

et al. 2022

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Magnetic nanocarriers have attracted attention in translational oncology due to their ability to be employed both for tumor diagnostics and therapy. This review summarizes data on applications of synthetic and biogenic magnetic nanoparticles (MNPs) in oncological theranostics and related areas. The basics of both types of MNPs including synthesis approaches, structure, and physicochemical properties are discussed. The properties of synthetic MNPs and biogenic MNPs are compared with regard to their antitumor therapeutic efficiency, diagnostic potential, biocompatibility, and cellular toxicity. The comparative analysis demonstrates that both synthetic and biogenic MNPs could be efficiently used for cancer theranostics, including biosensorics and drug delivery. At the same time, reduced toxicity of biogenic particles was noted, which makes them advantageous for in vivo applications, such as drug delivery, or MRI imaging of tumors. Adaptability to surface modification based on natural biochemical processes is also noted, as well as good compatibility with tumor cells and proliferation in them. Advances in the bionanotechnology field should lead to the implementation of MNPs in clinical trials.

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Section: Biogenic Nanoparticlesmentioning

confidence: 99%

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

et al. 2022

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“…Some strains (anaerobic bacteria) are also able to preferentially colonize hypoxic and necrotic tumor areas and penetrate deep tumor tissues. [9,10] Depending on the strain, bacteria can also possess the ability to move in response to chemical gradients (chemotaxis), [11][12][13][14][15][16] magnetic fields (magnetotaxis), [17][18][19][20] or oxygen concentration (aerotaxis). [21,22] This allows these microswimmers to follow a directional movement toward the stimulus.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the work on biohybrid microbots so far has been performed using flagellar bacterial strains such as Escherichia coli, [11,15,[23][24][25] Salmonella Typhimurium [16,[26][27][28] or magnetotactic bacterial strains such as Magnetococcus marinus MC-1. [18,19,29] Bacteria-based biohybrid microsystems are composed of at least one living motile bacterium and one synthetic particle. Typically, these systems consist of multiple nano-sized cargoes that are immobilized on one bacterium, or alternatively are composed of multiple bacteria that are attached to one microsized synthetic particle, and can also be generated by internalization of particulate cargo by bacterial cells (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Chemical Approaches for the Preparation of Bacteria – Nano/Microparticle Hybrid Systems

Bader

Klok

2022

Macromolecular Bioscience

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Bacteria represent a class of living cells that are very attractive carriers for the transport and delivery of nano‐ and microsized particles. The use of cell‐based carriers, such as for example bacteria, may allow to precisely direct nano‐ or microsized cargo to a desired site, which would greatly enhance the selectivity of drug delivery and allow to mitigate side effects. One key step towards the use of such nano‐/microparticle – bacteria hybrids is the immobilization of the cargo on the bacterial cell surface. To fabricate bacteria – nano‐/microparticle biohybrid microsystems, a wide range of chemical approaches are available that can be used to immobilize the particle payload on the bacterial cell surface. This article presents an overview of the various covalent and noncovalent chemistries that are available for the preparation of bacteria – nano‐/microparticle hybrids. For each of the different chemical approaches, an overview will be presented that lists the bacterial strains that have been modified, the type and size of nanoparticles that have been immobilized, as well as the methods that have been used to characterize the nanoparticle‐modified bacteria.

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“…To date, tremendous efforts are underway to develop micronanoswarms. As shown in Figure , because many factors play critical roles in the formation of swarms, including inherent properties of building blocks, different designs using artificial materials or natural organisms have been proposed to reliably form static or reconfigurable swarming patterns. − Biological and chemical powers are utilized to propel a part of micronanoswarms for moving . By applying external fields remotely on demand, including magnetic field, optical field, acoustic field, and electric field, , swarms can also be formed and actuated to make locomotion. , Furthermore, by tuning the parameters of applied fields, micronanoswarms are allowed to perform pattern reconfiguration and further endowed better flexibility to adapt complex external environments .…”

mentioning

confidence: 99%

An Overview of Micronanoswarms for Biomedical Applications

Chen

Zhang

et al. 2021

ACS Nano

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Micronanoswarms have attracted extensive attention worldwide due to their great promise in biomedical applications. The collective behaviors among thousands, or even millions, of tiny active agents indicate immense potential for benefiting the progress of clinical therapeutic and diagnostic methods. In recent years, with the development of smart materials, remote actuation modalities, and automatic control strategies, the motion dexterity, environmental adaptability, and functionality versatility of micronanoswarms are improved. Swarms can thus be designed as dexterous platforms inside living bodies to perform a multitude of tasks related to healthcare. Existing surveys summarize the design, functionalization, and biomedical applications of micronanorobots and the actuation and motion control strategies of micronanoswarms. This review presents the recent progress of micronanoswarms, aiming for biomedical applications. The recent advances on structural design of artificial, living, and hybrid micronanoswarms are summarized, and the biomedical applications that could be tackled using micronanoswarms are introduced, such as targeted drug delivery, hyperthermia, imaging and sensing, and thrombolysis. Moreover, potential challenges and promising trends of future developments are discussed. It is envisioned that the future success of these promising tools will have a significant impact on clinical treatment.

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Characterizations of magnetotactic bacteria conjugated versus unconjugated with carboxylate-Functionalized superparamagnetic iron oxide nanoparticles for tumor targeting purposes

Cited by 3 publications

References 6 publications

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

Chemical Approaches for the Preparation of Bacteria – Nano/Microparticle Hybrid Systems

An Overview of Micronanoswarms for Biomedical Applications

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