Characterization, solubility and stability of amentoflavone polymorphs

Zhou, Lina; Wang, Rong; Wang, Jingjin; Zhao, Kang; Zhang, Tao; Hu, Xiaolong; Xiong, Fei; Zhang, Xiaoqi; Ye, Wen‐Cai; Shi, Xin-Hong; Wang, Hao

doi:10.1016/j.molstruc.2022.133101

Cited by 6 publications

(1 citation statement)

References 25 publications

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“…Another factor that may affect the thermal sensitivity of myricitrin is its crystalline structure. The drying process can compromise the polymorphism of many substances, and different polymorphs have unique physicochemical characteristics, affecting their stability (Hao et al, 2020; Zhou et al, 2022). Thus, the process of obtaining SDE may have generated a polymorph that is more stable under heat stress than the standard myricitrin polymorph.…”

Section: Resultsmentioning

confidence: 99%

Validation of stability‐indicating LC method, degradation study, and impact on antioxidant and antifungal activities of Eugenia uniflora leaves extract

Santos

Lima

Machado

et al. 2023

Biomedical Chromatography

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The aim of this study is to demonstrate the stability‐indicating capacity of an analytical method for Eugenia uniflora, enhance understanding of the stability of myricitrin, and assess the effect of degradation of spray‐dried extract (SDE) on antioxidant and antifungal activities. Validation of the stability‐indicating method was carried out through a forced degradation study of SDE and standard myricitrin. The antioxidant and antifungal activities of SDE were evaluated both before and after degradation. The quantification method described was found to be both accurate and precise in measuring myricitrin levels in SDE from E. uniflora, with excellent selectivity that confirmed its stability‐indicating capability. The forced degradation study revealed that the marker myricitrin is sensitive to hydrolysis, but generally stable under other stress conditions. By contrast, the standard myricitrin displayed greater susceptibility to degradation under forced degradation conditions. Analysis of the antioxidant activity of SDE before and after degradation showed a negative impact in this activity due to degradation, while no significant effect was observed on antifungal activity. The method described can be a valuable tool in the quality control of E. uniflora, and the findings can assist in determining the optimal conditions and storage of products derived from this species.

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Section: Resultsmentioning

confidence: 99%