Characterization ofRana catesbeiana HSP30 gene and its expression in the liver of this amphibian during both spontaneous and thyroid hormone-induced metamorphosis

Helbing, Caren C.; Gallimore, Christopher; Atkinson, Burr G.

doi:10.1002/(sici)1520-6408(1996)18:3<223::aid-dvg3>3.0.co;2-b

Cited by 38 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of small HSPs differs considerably among different species. For instance, a single group is found in yeast, four in Drosophila (viz., HSP22, HSP23, HSP26 and HSP27), ten in humans (HSPB1 to HSPB10), sixteen in Xenopous laevis, and more than thirty small HSPs are reported in plants [225][226][227][228][229][230][231]. In Drosophila, small HSPs are clustered within 12 kb at locus 67B on chro-mosome 3L [232,233].…”

Section: Small Heat Shock Proteins (Hspb)mentioning

confidence: 99%

Heat Shock Response and Heat Shock Proteins: Current Understanding and Future Opportunities in Human Diseases

Singh,

Shin,

et al. 2024

IJMS

View full text Add to dashboard Cite

The heat shock response is an evolutionarily conserved mechanism that protects cells or organisms from the harmful effects of various stressors such as heat, chemicals toxins, UV radiation, and oxidizing agents. The heat shock response triggers the expression of a specific set of genes and proteins known as heat shock genes/proteins or molecular chaperones, including HSP100, HSP90, HSP70, HSP60, and small HSPs. Heat shock proteins (HSPs) play a crucial role in thermotolerance and aiding in protecting cells from harmful insults of stressors. HSPs are involved in essential cellular functions such as protein folding, eliminating misfolded proteins, apoptosis, and modulating cell signaling. The stress response to various environmental insults has been extensively studied in organisms from prokaryotes to higher organisms. The responses of organisms to various environmental stressors rely on the intensity and threshold of the stress stimuli, which vary among organisms and cellular contexts. Studies on heat shock proteins have primarily focused on HSP70, HSP90, HSP60, small HSPs, and ubiquitin, along with their applications in human biology. The current review highlighted a comprehensive mechanism of heat shock response and explores the function of heat shock proteins in stress management, as well as their potential as therapeutic agents and diagnostic markers for various diseases.

show abstract

Section: Small Heat Shock Proteins (Hspb)mentioning

confidence: 99%

Heat Shock Response and Heat Shock Proteins: Current Understanding and Future Opportunities in Human Diseases

Singh,

Shin,

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Spatial pattern of constitutive and heat shock-induced expression of the small heat shock protein gene family, hsp30, inXenopus laevis tailbud embryos

et al. 1999

View full text Add to dashboard Cite

Distinctive gene profiles occur at key points during natural metamorphosis in the Xenopus laevis tadpole tail

Veldhoen

Crump

Werry

et al. 2002

Developmental Dynamics

View full text Add to dashboard Cite

Thyroid hormones (THs) are essential for tadpole metamorphosis into a juvenile frog; however, a complex interplay between additional hormones and signaling events also contributes to this dramatic developmental phase. A major mechanism of TH action is the nuclear receptor-mediated regulation of gene transcription of responsive genes. By using the precocious metamorphic model, several genes have been identified as TH responsive in the regressing tail. Many of these genes also exhibit altered expression during natural metamorphosis. Although identification of these genes provides insight into the mechanism whereby TH acts, complex interplay between TH and other hormones and the developmental stage-dependency of tissue responses contribute to the timing and coordination of metamorphic events. We investigated the temporal gene expression profile in Xenopus laevis tadpole tails from premetamorphosis through metamorphic climax by using a combination of a novel frog cDNA array containing 420 genes and quantitative real-time PCR. Seventy-nine genes were identified whose steady-state mRNA expression levels were altered in the tadpole tail during natural metamorphosis, of which 34 have previously been identified to be TH responsive in frogs or mammals. Of these genes, 75 clustered into 13 groups that displayed distinct developmental expression profiles. The levels of 28 transcripts were altered during premetamorphosis, 31 during prometamorphosis, and 43 with the onset of tail regression. This work establishes an important baseline for determining the mechanisms whereby tissues undergo differing metamorphic fates.

show abstract

Characterization ofRana catesbeiana HSP30 gene and its expression in the liver of this amphibian during both spontaneous and thyroid hormone-induced metamorphosis

Cited by 38 publications

References 52 publications

Heat Shock Response and Heat Shock Proteins: Current Understanding and Future Opportunities in Human Diseases

Heat Shock Response and Heat Shock Proteins: Current Understanding and Future Opportunities in Human Diseases

Spatial pattern of constitutive and heat shock-induced expression of the small heat shock protein gene family, hsp30, inXenopus laevis tailbud embryos

Distinctive gene profiles occur at key points during natural metamorphosis in the Xenopus laevis tadpole tail

Contact Info

Product

Resources

About