Characterization of α2-adrenoceptors in the rat: proximal tubule, renal membrane and whole kidney studies

Stanko, Carmen K.; Vandel, Marilyne; Bose, Ratna; Smyth, Donald D.

doi:10.1016/0014-2999(90)90146-w

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…Additional studies have shown that at the dose used in this study, verapamil could also be expected to directly an tagonize agonist binding to alpha-2 adrenoceptors [7], Ve rapamil also inhibited the effect of efferent adrenergic nerve stimulation on the renal vasculature [8J. In the present study, the vascular effects of verapamil on alpha adrenergic activity were most likely minimal since verapamil had no effect on renal hemodynamics as reflected by the GFR.…”

Section: Discussionmentioning

confidence: 56%

“…The natriuretic effect of verapamil in vivo could be due to its hemodynamic actions, to directly inhibiting tubule reabsorption, or to antagonism o f antinatriuretic hormones within the kidney [7][8][9][10]. The existence of L-type calcium channels in renal tubule cells is questionable.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, verapamil has been shown to antag onize the antinatriuretic effect of alpha adrenergic activity and ANG-II in the kidney [7,8,12,13]. Therefore, the pre sent study was designed to determine whether verapamil al so reverses the antinatriuretic effect of PGE2 in the rat.…”

Section: Introductionmentioning

confidence: 99%

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Reversal of the Antinatriuretic Effect of Prostaglandin E<sub>2</sub> by Verapamil in the Rat

Peng¹,

Ramsey²,

Knox³

1996

Kidney Blood Press Res

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Previous studies have demonstrated that prostaglandin E₂ (PGE₂) infusion increases intrarenal angiotensin-II (ANG-II) formation and decreases sodium excretion in the rat. PGE₂ infusion may have direct tubular effects or indirect effects through increased intrarenal ANG-II. In the present study, the calcium channel blocker verapamil was used to determine whether it would reverse the PGE₂-induced decrease in sodium excretion. To minimize any systemic and hemodynamic influences, verapamil and PGE₂ were infused directly into the renal interstitium via a chronically implanted matrix. Fractional sodium excretion (FE_Na), glomerular filtration rate (GFR), mean arterial pressure (MAP), and plasma renin activity (PRA) were measured before and during renal interstitial infusion of PGE₂ (10^-5M) and/or verapamil (10^-3M) in rats pretreated with indomethacin. The renal interstitial infusion of PGE₂ alone significantly decreased FE_Na (Δ-1.0 ± 0.2%), whereas the addition of verapamil reversed the effect of PGE₂ and significantly increased FE_Na (Δ2.6 ± 0.3%, n = 9). The renal interstitial infusion of verapamil alone markedly increased FE_Na (△1.7 ± 0.3%, n = 7), and this natriuresis was accompanied by a significant decrease in PRA (Δ-0.6 ± 0.1 ng/ml/h, p < 0.05). The addition of PGE₂ to the interstitial infusion did not further affect FE_Na or PRA. There was a significant difference between the effect of interstitial PGE₂ infusion and interstitial verapamil infusion on PRA (Δ1.9 ± 0.8 vs. Δ-0.6 ± 0.1 ng/ml/h, p < 0.05). GFR and MAP remained unchanged in response to the renal interstitial infusion of PGE₂ and/or verapamil. In conclusion, verapamil reversed the PGE₂-induced antinatriuresis in the rat.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

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Reversal of the Antinatriuretic Effect of Prostaglandin E<sub>2</sub> by Verapamil in the Rat

Peng¹,

Ramsey²,

Knox³

1996

Kidney Blood Press Res

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“…Os receptores a 2 -adrenérgicos são classificados em á 2 A, á 2 B e á 2 C, conforme sua ação farmacológica e em a 2 C10, a 2 C2 e a 2 C4, conforme a localização cromossômica dos genes que os codificam e correspondem, respectivamente, aos a 2 A, a 2 B e a 2 C 13 . Os receptores a 2 pré-juncionais são principalmente os a 2 A, embora possam estar presentes também os a 2 C 14 .…”

Section: Mecanismo De Açãounclassified

Uso de dexmedetomidina em anestesiologia

Villela¹,

Júnior²

2003

Rev. Bras. Anestesiol.

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RESUMO e d i c a ç ã o p r é -a n e s t é s i c a , o u d u r a n t e o a t o anestésico-cirúrgico. O mecanismo de ação dos fármacos a 2 -a g o n i s ta s e a s p r o p r i e d a d e s f a r m a c o c i n é t i c a s e farmacodinâmicas da dexmedetomidina também são revistos neste artigo. Conclusões -O uso da dexmedetomidina como medicação p r é -a n e s t é s i c a , d u r a n t e a n e s t e s i a , o u n o p e r í o d o pós-operatório

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“…Os receptores α 2 -adrenérgicos foram identificados em vários segmentos renais de diversas espécies, inclusive no cão e homem (Michel et al, 1989;Callianos & Muntz, 1990;Stanko et al, 1990;Clarke & Garg, 1993;Evans & Haynes, 1994).…”

Section: Atributosunclassified

Efeitos da dexmedetomidina em rins isquêmicos e sobre a concentração plasmática do hormônio antidiurético

Bitencourt¹

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Characterization of α2-adrenoceptors in the rat: proximal tubule, renal membrane and whole kidney studies

Cited by 11 publications

References 19 publications

Reversal of the Antinatriuretic Effect of Prostaglandin E<sub>2</sub> by Verapamil in the Rat

Reversal of the Antinatriuretic Effect of Prostaglandin E<sub>2</sub> by Verapamil in the Rat

Uso de dexmedetomidina em anestesiologia

Efeitos da dexmedetomidina em rins isquêmicos e sobre a concentração plasmática do hormônio antidiurético

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