2019
DOI: 10.3389/fphys.2019.00248
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Characterization of α-Glucosidases From Lutzomyia longipalpis Reveals Independent Hydrolysis Systems for Plant or Blood Sugars

Abstract: Lutzomyia longipalpis is the main vector of Leishmania infantum and exploits different food sources during development. Adults have a diet rich in sugars, and females also feed on blood. The sugar diet is essential for maintaining longevity, infection, and Leishmaniasis transmission. Carbohydrases, including α-glucosidases, are the main enzymes involved in the digestion of sugars. In this context, we studied the modulation of α-glucosidase activities in different feeding condi… Show more

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Cited by 13 publications
(19 citation statements)
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“…Insect α-glucosidase is classified as family I. Family I α-glucosidase has four conserved regions, which can also be found in α-amylase, but there is no sequence similarity between them [ 63 ]. Carbohydrases are often used as targets for pesticides, such as amylases or glucosidase inhibitors [ 64 , 65 ].…”
Section: Discussionmentioning
confidence: 99%
“…Insect α-glucosidase is classified as family I. Family I α-glucosidase has four conserved regions, which can also be found in α-amylase, but there is no sequence similarity between them [ 63 ]. Carbohydrases are often used as targets for pesticides, such as amylases or glucosidase inhibitors [ 64 , 65 ].…”
Section: Discussionmentioning
confidence: 99%
“…This enzyme, which removes α-(1-6) linkages, detaches from glycogen units of glucose and is important for continued glycogen breakdown during insect flight [45]. Alpha-glucosidase catalyzes the hydrolysis of α-glucosidic bonds, releasing free glucose; this enzyme is present as a soluble form in the midgut lumen or bound to cell membranes and is important for the digestion of sucrose [46,47]. Trehalase is the enzyme that hydrolyses trehalose, a circulating disaccharide containing two D-glucose units in an α,α-(1-1) linkage, which plays a crucial role as a metabolic source of energy [48].…”
Section: Proteins Identifiedmentioning
confidence: 99%
“…Many insect species are an important source of proteins, peptides, secondary metabolites, and polymers, such as silk, chitin, and chitosan used by the pharmaceutical and food industries (Milusheva and Rashidova 2017, Teramoto et al 2019). Since they have numerous metabolic and genetic adaptations to cope with diverse environments, mainly through the production of specialized molecules and enzymes (Dias et al 2015, Hardersen and Zapponi 2018, Da Costa et al 2019, Kannan et al 2019), insects are increasingly considered as an alternative source for discovering compounds of biotechnological interest (Seabrooks and Hu 2017). In this context, insect pests have been analyzed as biological material for their potential as sources of food and bioactive compounds.…”
mentioning
confidence: 99%