Characterization of vaginal microbiota in Thai women

Abstract

BackgroundThe vaginal microbiota (VMB) plays a key role in women’s reproductive health. VMB composition varies with ethnicity, making it necessary to characterize the VMB of the target population before interventions to maintain and/or improve the vaginal health are undertaken. Information on the VMB of Thai women is currently unavailable. We therefore characterized the VMB in normal Thai women.MethodsVaginal samples derived from 25 Thai women were subjected to 16S rRNA gene next-generation sequencing (NGS) on the Ion Torrent PGM platform.ResultsTwo groups of VMB were detected, lactobacilli-dominated (LD) and non-lactobacilli dominated (NLD) groups. Lactobacillus iners was the most common species found in the LD group while Gardnerella vaginalis followed by Atopobium vaginae and Pseudumonas stutzeri were commonly found in the NLD group.ConclusionsThe VMB patterns present in normal Thai women is essential information to further determine the factors associated with VMB patterns in vaginal health and disease and to develop proper management of reproductive health of Thai women.

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“…iners (OTU1) (data not shown) was the most abundant taxon in the endocervical milieu of both infected and non-infected group. Such dominance has been previously reported among normal healthy reproductive Thai and Chinese women [46, 47]. L .…”

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“…Microorganisms exist in a finely tuned mutualistic relationship with the host, and provide the first line of defense against colonization and infection by pathogens (Smith and Ravel, 2017). The dominant bacterial species in human vagina belong to the genus Lactobacillus (Martin, 2012;Sirichoat et al, 2018). However, species of other genera, such as Gardnerella, Atopobium, Prevotella, Corynebacterium, Anaerococcus, Peptoniphilus, can, under certain conditions, constitute majority populations (Martin, 2012;Sirichoat et al, 2018).…”

“…The dominant bacterial species in human vagina belong to the genus Lactobacillus (Martin, 2012;Sirichoat et al, 2018). However, species of other genera, such as Gardnerella, Atopobium, Prevotella, Corynebacterium, Anaerococcus, Peptoniphilus, can, under certain conditions, constitute majority populations (Martin, 2012;Sirichoat et al, 2018). Species of Enterococcus and Streptococcus genera are frequently isolated as subdominant populations.…”