Characterization of tyramine and octopamine receptors in the insect (Locusta migratoria migratorioides) brain

Hiripi, L.; Juhos, Szilveszter; Downer, Roger

doi:10.1016/0006-8993(94)91530-x

Cited by 60 publications

(38 citation statements)

References 37 publications

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“…Another benefit of being able to express a putative receptor at will is that it makes direct pharmacological and physiological analyses of expected (Evans, 1980;Evans, 1981) and unexpected novel receptor subtypes (Venter et al, 1988) more straightforward, with certain limitations, as mentioned above (Hiripi et al, 1994;Hirashima et al, 2003;Lee et al, 2003;Rex et al, 2004;Cazzamali et al, 2005;, Klaerke & Grimmelikhuijzen, 2005;Ohta et al 2005).…”

Section: Invertebrate Trace Amine-activated Receptorsmentioning

confidence: 99%

Trace amine-associated receptor 1—Family archetype or iconoclast?

Grandy

2007

Pharmacology & Therapeutics

176

211

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Interest has recently been rekindled in receptors that are activated by low molecular weight, noncatecholic, biogenic amines that are typically found as trace constituents of various vertebrate and invertebrate tissues and fluids. The timing of this resurgent focus on receptors activated by the 'trace amines' (TAs) β-phenylethylamine (PEA), tyramine (TYR), octopamine (OCT), synephrine (SYN), and tryptamine (TRYP) is the direct result of two publications that appeared in 2001 describing the cloning of a novel G protein-coupled receptor (GPCR) referred to by their discoverers as TA1 (Borowsky et al., 2001) and TAR1 (Bunzow et al., 2001). When heterologously expressed in Xenopus laevis oocytes and various eukaryotic cell lines recombinant rodent and human TA receptors dosedependently couple to the stimulation of cAMP production. Structure-activity profiling based on this functional response has revealed that in addition to the TAs, other biologically active compounds containing a 2 carbon aliphatic side chain linking an amino group to at least one benzene ring are potent and efficacious TA receptor agonists with amphetamine, methamphetamine, 3-iodothyronamine, thyronamine, and dopamine among the most notable. Almost 100 years after the search for TA receptors began numerous TA1/TAR1-related sequences, now called Trace AmineAssociated Receptors (TAARs), have been identified in the genome of every species of vertebrate examined to date. Consequently, even though heterologously expressed TAAR1 fits the pharmacological criteria established for a bona fide TA receptor a major challenge for those working in the field is to discern the in vivo pharmacology and physiology of each purported member of this extended family of GPCRs. Only then will it be possible to establish whether TAAR1 is the family archetype or an iconoclast.

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Section: Invertebrate Trace Amine-activated Receptorsmentioning

confidence: 99%

Trace amine-associated receptor 1—Family archetype or iconoclast?

Grandy

2007

Pharmacology & Therapeutics

176

211

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“…The OAMB receptor is coupled to Ca 2+ accumulation (Zeng et al, 1996;Han et al, 1998;Grohmann et al, 2003;Balfanz et al, 2005;Evans and Maqueira, 2005). Orthologs of OAMB have subsequently been identified in Apis (Blenau and Baumann, 2001;Grohmann et al, 2003;Balfanz et al, 2014), Anopheles (Kastner et al, 2014), Schistocerca (Verlinden et al, 2010b), and Locusta (Hiripi et al, 1994;Ma et al, 2015), among other invertebrate species. Whether the OAMB receptor is a true OCT receptor or a mixed OCT/TYR receptor has been a matter of some recent conjecture (El-Kholy et al, 2015).…”

Section: Octopamine Receptorsmentioning

confidence: 99%

Trace Amines and Their Receptors

Gainetdinov¹,

Hoener²,

Berry³

2018

Pharmacol Rev

280

287

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“…sical octopamine receptor agonists, such as octopamine itself, demethylchlordimeform, naphazoline and synephrine are relatively ineffective at the locust tyramine receptor (Hiripi et al, 1994). To distinguish the octopamine and tyramine receptor in the locust nervous tissue, even better antagonists are available.…”

Section: Biogenic Aminesmentioning

confidence: 99%

“…With only three amines, octopamine, tyramine and noradrenaline is it possible to distinguish octopamine receptors from their closest relatives, the vertebrate a-adrenoceptors and the insect tyramine receptors (Saudou et al, 1992;Hiripi et al, 1994). Octopamine has the highest affinity, followed by tyramine and noradrenaline for the octopamine receptor, but octopamine and tyramine change places in their affinity for the insect tyramine receptor.…”

Section: Biogenic Aminesmentioning

confidence: 99%

Pharmacology of the octopamine receptor from locust central nervous tissue (OAR3)

Roeder

1995

British J Pharmacology

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1 The present study characterized highly effective agonists from different classes of compounds for the neuronal octopamine receptor (OAR3) of the migratory locust (Locusta migratoria L.). Biogenic amines and phenyliminoimidazolidines (PIls) were employed for the study of structure-activity relationships. 2 The highest affinity PIls were predominantly those with substitutions at the positions 2 and 4 of the phenolic ring (e.g. NC 7, K, = 0.3 nM, NC 8, K, = 0.81 nM). Substitutions at these positions always had positive effects on the affinity of the respective agonists. 3 Substitutions at the positions 3, 5 and 6, however, always had negative effects on the affinity. At the position one of the phenolic ring, heterocyclic substituents are preferred. 4 Some PIMs had a more than 30 times higher affinity for OARs than for a-adrenoceptors which are the vertebrate homologues of the insect octopamine receptors. 5 The only non-PII with subnanomolar affinity was the aminooxazoline derivative AC 6 (K1 = 0.92 nM). 6 A variety of substances with known insecticidal activity such as chlordimeform, demethylchlordimeform, amitraz or AC 6 had high affinity for the locust neuronal octopamine receptor.

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Characterization of tyramine and octopamine receptors in the insect (Locusta migratoria migratorioides) brain

Cited by 60 publications

References 37 publications

Trace amine-associated receptor 1—Family archetype or iconoclast?

Trace amine-associated receptor 1—Family archetype or iconoclast?

Trace Amines and Their Receptors

Pharmacology of the octopamine receptor from locust central nervous tissue (OAR3)

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