Characterization of Tula Virus from Common Voles (Microtus Arvalis) in Poland: Evidence for Geographic-Specific Phylogenetic Clustering

Song, Jin Won; Baek, Luck Ju; Song, Ki Joon; Skrok, Anna; Markowski, Janusz; Bratosiewicz-Wąsik, Jolanta; Kordek, Radzisław; Liberski, Paweł P.; Yanagihara, Richard

doi:10.1023/b:viru.0000036384.50102.cf

Cited by 35 publications

(31 citation statements)

References 28 publications

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“…Previously, TULV was isolated from the common vole in central Poland (Song et al, 2004), and anti-hantavirus antibodies were reported among Polish mammalogists (Sadkowska-Todys et al, 2007) and forestry workers (Grygorczuk et al, 2008). The first serologically confirmed case of HFRS, occurring in May 2005, was reported in 2006 (Knap et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Co-circulation of soricid- and talpid-borne hantaviruses in Poland

Gu¹,

Hejduk²,

Markowski³

et al. 2014

Infection, Genetics and Evolution

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Previously, we reported the discovery of a genetically distinct hantavirus, designated Boginia virus (BOGV), in the Eurasian water shrew (Neomys fodiens), as well as the detection of Seewis virus (SWSV) in the Eurasian common shrew (Sorex araneus), in central Poland. In this expanded study of 133 shrews and 69 moles captured during 2010–2013 in central and southeastern Poland, we demonstrate the co-circulation of BOGV in the Eurasian water shrew and SWSV in the Eurasian common shrew, Eurasian pygmy shrew (Sorex minutus) and Mediterranean water shrew (Neomys anomalus). In addition, we found high prevalence of Nova virus (NVAV) infection in the European mole (Talpa europaea), with evidence of NVAV RNA in heart, lung, liver, kidney, spleen and intestine. The nucleotide and amino acid sequence variation of the L segment among the SWSV strains was 0–18.8% and 0–5.4%, respectively. And for the 38 NVAV strains from European moles captured in Huta Dłutowska, the L-segment genetic similarity ranged from 94.1–100% at the nucleotide level and 96.3–100% at the amino acid level. Phylogenetic analyses showed geographic-specific lineages of SWSV and NVAV in Poland, not unlike that of rodent-borne hantaviruses, suggesting long-standing host-specific adaptation. The co-circulation and distribution of BOGV, SWSV and NVAV in Poland parallels findings of multiple hantavirus species coexisting in their respective rodent reservoir species elsewhere in Europe. Also, the detection of SWSV in three syntopic shrew species resembles spill over events observed among some rodent-borne hantaviruses.

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Section: Resultsmentioning

confidence: 99%

Co-circulation of soricid- and talpid-borne hantaviruses in Poland

Gu¹,

Hejduk²,

Markowski³

et al. 2014

Infection, Genetics and Evolution

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“…Similar patterns of geographic variation have also been reported for rodentborne hantaviruses. For example, geographic-specific genetic variants have been reported for Puumala virus in the bank vole (Myodes glareolus) (Garanina et al 2009), Tula virus in the European common vole (Microtus arvalis) (Song et al 2004), and Andes virus in the colilargo (Oligoryzomys longicaudus) (Torres-Perez et al 2011). Both Muju virus in the royal vole (Myodes regulus) (Lee et al 2014) and Hokkaido virus in the grey red-backed vole (Myodes rufocanus) and northern red-backed vole (Myodes rutilus) (Yashina et al 2015) may represent genotypes of Puumala virus.…”

Section: Resultsmentioning

confidence: 99%

Genetic Diversity of Artybash Virus in the Laxmann's Shrew (Sorex caecutiens)

Arai

Kang

et al. 2016

Vector-Borne and Zoonotic Diseases

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Although based on very limited M and L segment sequences, Artybash virus (ARTV) was proposed previously as a unique hantavirus harbored by the Laxmann's shrew (Sorex caecutiens). To verify this conjecture, lung tissues from 68 Laxmann's shrews, captured during 2006 to 2014 in eastern Siberia, Russia, and Hokkaido, Japan, were analyzed for ARTV RNA using reverse transcription polymerase chain reaction (RT-PCR). ARTV RNA was detected in six Laxmann's shrews. Pairwise alignment and comparison of partial-and full-length S, M, and L segment sequences from these Laxmann's shrews, as well as phylogenetic analyses, using maximum likelihood and Bayesian methods indicated that ARTV was distinct from other soricine shrew-borne hantaviruses and representative hantaviruses harbored by rodents, moles, and bats. Taxonomic identity of the ARTVinfected Laxmann's shrews was confirmed by full-length cytochrome b mitochondrial DNA sequence analysis. Our data indicate that the hantavirus previously known as Amga virus (MGAV) represents genetic variants of ARTV. Thus, the previously proposed designation of ARTV/MGAV should be replaced by ARTV.

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“…Recent PUUV-HFRS outbreaks in Western Europe (Heyman et al 2007) are presumed to be caused from a causal connection of higher summer temperatures leading to increased frequency of masting of European beech (Fagus sylvatica) and pedunculate oak (Quercus robur), providing an abundance of food for bank voles allowing for population increases and supporting PUUV transmission (Tersago et al 2009(Tersago et al , 2010) (see also section below). Tula virus is a fifth hantavirus found in many parts of Europe (Song et al 2004). It is associated with the common vole (Microtus arvalis; Fig.…”

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confidence: 99%

Hantaviruses and Their Hosts in Europe: Reservoirs Here and There, But Not Everywhere?

Olsson

Leirs²,

Henttonen

2010

Vector-Borne and Zoonotic Diseases

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Five hantaviruses are known to circulate among rodents in Europe, and at least two among insectivores. Four (Dobrava, Saaremaa, Seoul, and Puumala [PUUV] viruses) are clearly associated with hemorrhagic fever with renal syndrome (HFRS). PUUV, the most common etiological agent of HFRS in Europe, is carried by the bank vole (Myodes glareolus), one of the most widespread and abundant mammal species in Europe. This host-virus system is among hantaviruses also the most studied one in Europe. However, HFRS incidence varies throughout the continent. The spatial as well as temporal variation in the occurrence of HFRS is linked to geographic differences in the population dynamics of the reservoir rodents in different biomes of Europe. While rodent abundance may follow mast seeding events in many parts of temperate Europe, in northern (N) Europe multiannual cycles in population density exist as the result of the interaction between rodent populations and specialist predator populations in a delayed density-dependent manner. The spatial distribution of hantaviruses further depends on parameters such as forest patch size and connectivity of the most suitable rodent habitats, and the conditions for the survival of the virus outside the host, as well as historical distribution patterns (phylogeographies) of hosts and viruses. In multiannually fluctuating populations of rodents, with population increases of great amplitude, one should expect a simultaneous build-up of recently hantavirus-infected (shedding) rodents. The increasing number of infectious, virus-shedding rodents leads to a rapid transmission of hantavirus across the rodent population, and to humans. Our review discusses these aspects for PUUV, the only European hantavirus for which there is a reasonable, yet still far from complete, ecological continental-wide understanding. We discuss how this information could translate to other European hantavirus-host systems, and where the most important questions lie for further research.

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Characterization of Tula Virus from Common Voles (Microtus Arvalis) in Poland: Evidence for Geographic-Specific Phylogenetic Clustering

Cited by 35 publications

References 28 publications

Co-circulation of soricid- and talpid-borne hantaviruses in Poland

Co-circulation of soricid- and talpid-borne hantaviruses in Poland

Genetic Diversity of Artybash Virus in the Laxmann's Shrew (Sorex caecutiens)

Hantaviruses and Their Hosts in Europe: Reservoirs Here and There, But Not Everywhere?

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