Characterization of troponin I levels post synchronized direct current cardioversion of atrial arrhythmias in patients with and without cardiomyopathy

Sless, Ryan Taylor; Allen, Gerry; Hayward, Nathaniel E.; Fahy, Gerard J.

doi:10.1007/s10840-020-00814-x

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…To the best of our knowledge this is the first published investigation about the onset of regional changes in systolic and diastolic biventricular function after transthoracic shocks. Previous imaging investigations have focused on global volumetric changes, while other non-invasive techniques have utilized serology markers 3 , 6 , 22 , 23 . Yet, the electrical pathway from transthoracic shocks can vary across the heart and these global techniques cannot identify the unique distributions of myocardial injury that occur as a result.…”

Section: Discussionmentioning

confidence: 99%

“…In electroporation injury, the applied current forces ions through the cellular membranes, which disrupts the delicate balance of ions and molecules along the intracellular and extracellular side of the cell membrane, therefore causing an osmotic water influx into the cell and edema 26 . Many studies have focused on serological markers, such as troponins and creatinine kinases 22 , 23 , 27 . However, the evidence is not consistent and biomarkers cannot determine the exact location of the injury.…”

Section: Discussionmentioning

confidence: 99%

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Feature tracking strain analysis detects the onset of regional diastolic dysfunction in territories with acute myocardial injury induced by transthoracic electrical interventions

Fischer

Becker

Mongeon

et al. 2022

Sci Rep

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Electric interventions are used to terminate arrhythmia. However, myocardial injury from the electrical intervention can follow unique pathways and it is unknown how this affects regional ventricular function. This study investigated the impact of transthoracic electrical shocks on systolic and diastolic myocardial deformation. Ten healthy anaesthetized female swine received five transthoracic shocks (5 × 200 J) and six controls underwent a cardiovascular magnetic resonance exam prior to and 5 h after the intervention. Serial transthoracic shocks led to a global reduction in both left (LV, − 15.6 ± 3.3% to − 13.0 ± 3.6%, p < 0.01) and right ventricular (RV, − 16.1 ± 2.3% to − 12.8 ± 4.2%, p = 0.03) peak circumferential strain as a marker of systolic function and to a decrease in LV early diastolic strain rate (1.19 ± 0.35/s to 0.95 ± 0.37/s, p = 0.02), assessed by feature tracking analysis. The extent of myocardial edema (ΔT1) was related to an aggravation of regional LV and RV diastolic dysfunction, whereas only RV systolic function was regionally associated with an increase in T1. In conclusion, serial transthoracic shocks in a healthy swine model attenuate biventricular systolic function, but it is the acute development of regional diastolic dysfunction that is associated with the onset of colocalized myocardial edema.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Feature tracking strain analysis detects the onset of regional diastolic dysfunction in territories with acute myocardial injury induced by transthoracic electrical interventions

Fischer

Becker

Mongeon

et al. 2022

Sci Rep

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show abstract

“…Cardiovascular disease often leads to an ischemic m y o c a r d i u m . W h i l e t h e r a p y s u c h a s p r o m o t i n g myocardial blood supply, reducing oxygen consumption, and interventional therapy can restore the myocardial ischemia to a normal perfusion status (1,2), a long duration of secondary myocardial injury may follow, affecting myocardial ultrastructure, energy metabolism, cardiac function, and electrophysiology (3)(4)(5)(6). This injury is defined as myocardial ischemia-reperfusion injury (MIRI), which is the leading cause of morbidity and mortality (7).…”

Section: Introductionmentioning

confidence: 99%

Lycium barbarum polysaccharide protects cardiomyocytes from hypoxia/reoxygenation injury via activation of SIRT3/CypD signaling

Wu¹,

Liu²,

Yu³

et al. 2023

Ann Transl Med

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Background Myocardial ischemia-reperfusion is a common pathological feature of many heart and vascular diseases, but the molecular mechanism of this process is still unclear, and there is no effective way to protect cardiomyocytes. The aim of this study was to examine the effects and underlying molecular mechanisms of Lycium barbarum polysaccharide (LBP) on myocardial ischemia-reperfusion injury in cardiomyocytes. Methods The cardiomyocyte cell line H9c2 were used to establish an in vitro hypoxia/reoxygenation (H/R) model. After treatment with LBP and/or the SIRT3 inhibitor 3-TYP, cell morphology was observed under the light microscopy. The Cell Counting Kit (CCK)-8 and 5-ethynyl-2'-deoxyuridine (EdU) assay were used to detect cell proliferation, and flow cytometry was performed to assess cell apoptosis. The lysine (166)-acetylation of CypD1 was determined by co-immunoprecipitation assay. Enzyme-linked immunosorbent assay (ELISA) was used to determine the lactate dehydrogenase (LDH) level in the culture medium. Na + -K + -ATPase activity, Ca 2+ -ATPase activity, and nitric oxide (NO) levels were measured. Results LBP alleviated cell damage and upregulated STIR3 expression in a dose-dependent manner. Upregulated SIRT3 expression and suppressed acetylation of CypD were also observed in H/R-induced H9c2 cells treated with LBP. Indeed, LBP remarkably reversed the inhibition of proliferation and cell apoptosis in H/R-induced H9c2 cells by activating SIRT3/CypD signaling. Blockade of SIRT3 with SIRT3 inhibitor (3-TYP) inhibited the protective effect of LBP on H9c2 cells. LBP markedly alleviated the H/R-induced increase of LDH release, and the decrease of Na + -K + -ATPase activity, Ca 2+ -ATPase activity, and NO levels. Inhibition of SIRT3 restored the protective effects of LBP. Conclusions LPB induced deacetylation of CypD by upregulating SIRT3, thereby protecting mitochondrial function and relieving H/R-induced injury in cardiomyocytes.

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Evaluation von Troponin-I-Serumspiegeln bei Patienten mit Arrhythmien mit und ohne Vorliegen einer koronaren Herzkrankheit

Bandorski¹,

Höltgen²,

Wieczorek³

et al. 2023

Med Klin Intensivmed Notfmed

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Characterization of troponin I levels post synchronized direct current cardioversion of atrial arrhythmias in patients with and without cardiomyopathy

Cited by 3 publications

References 27 publications

Feature tracking strain analysis detects the onset of regional diastolic dysfunction in territories with acute myocardial injury induced by transthoracic electrical interventions

Feature tracking strain analysis detects the onset of regional diastolic dysfunction in territories with acute myocardial injury induced by transthoracic electrical interventions

Lycium barbarum polysaccharide protects cardiomyocytes from hypoxia/reoxygenation injury via activation of SIRT3/CypD signaling

Evaluation von Troponin-I-Serumspiegeln bei Patienten mit Arrhythmien mit und ohne Vorliegen einer koronaren Herzkrankheit

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