Characterization of trace elements in Casearia medicinal plant by neutron activation analysis

Yamashita, Celina Izumi; Saiki, M.; Vasconcellos, M. B. A.; Sertié, Jayme Antônio Aboin

doi:10.1016/j.apradiso.2005.05.045

Cited by 51 publications

(19 citation statements)

References 20 publications

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“…The investigation of contaminants in the samples was performed by the (NAA-k 0 ), which is the most appropriate method for this type of investigation, since it allows to determine the presence and concentration of several elements simultaneously, in trace levels, parts per billion (ppb), without any complex sample preparation. The elemental concentration is obtained through the spectra of the gamma radiation emitted by the elements present in the matrix, which become radioactive after beING irradiated by neutron of a nuclear research reactor (Leal et al, 2006;Menezes, Jacimovic, 2006;Yamashita et al, 2005). The samples were first crushed and sieved, when necessary, homogenized, weighed (approximately 200 mg) and placed into polyethylene tubes.…”

Section: Sene (De)mentioning

confidence: 99%

Determination of metals in medicinal plants highly consumed in Brazil

Leal

Prado

Gomes

et al. 2013

Braz. J. Pharm. Sci.

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In this work, samples of the medicinal plants: Boldo (Peumus boldus), Castanha da Índia (Aesculus hippocastanum), Chá Verde (Camelia sinensis), Erva Cidreira (Melissa officinalis), Espinheira Santa (Maytenus ilicifolia), Guaraná (Paullinia cupana), Maracujá (Passiflora sp.), Mulungu (Erythrina velutina), Sene (Cassia angustifolia) and Valeriana (Valeriana officinalis) were evaluated BY using the Neutron Activation Analysis technique (NAA-k 0 ) in order to determine the levels of metals and other chemical contaminants. The results showed the presence of non essential elements to the human body. The diversity of chemical impurities found even at low concentration levels, considering the potential for chronic toxicity of these elements, reinforces the need to improve the implementation of good practices by growers and traders, and the hypothesis of lack of quality control in plant products. (AAN-k 0 ), a fim de se determinar os teores de metais e outros elementos químicos contaminantes. Os resultados revelaram a presença de elementos não essenciais ao organismo humano. A diversidade de impurezas químicas encontradas, mesmo em níveis de baixa concentração, considerando o potencial de toxicidade crônica desses elementos, reforça a necessidade de melhorias na aplicação de boas práticas pelos produtores e comerciantes e a hipótese de falta de controle de qualidade nos produtos vegetais.Unitermos: Análise por ativação neutrônica/análise quantitativa. Plantas medicinais. Metais/determinação em plantas medicinais. Contaminantes químicos/determinação em plantas medicinais. Produtos vegetais/ controle de qualidade.

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Section: Sene (De)mentioning

confidence: 99%

Determination of metals in medicinal plants highly consumed in Brazil

Leal

Prado

Gomes

et al. 2013

Braz. J. Pharm. Sci.

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“…Their deficiency causes diseases, whereas the excess presence may cause toxicity (Hashmi et al, 2007). Mineral contents of several medicinal plants have been determined by applying several techniques such as atomic absorption spectroscopy (Negi et al, 2010), atomic emission spectrometry (Razic et al, 2003), electrothermal atomic absorption spectrometry (Gomez et al, 2004), X-ray emission (Mohanta et al, 2003), X-ray fluorescence (Salvador et al, 2003), inductively coupled plasma mass spectrometry (Falco et al, 2003) and neutron activation analysis (Yamashita et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Determination of mineral contents of Digitalis purpurea L. and Digitalis lanata Ehrh

Negi¹,

Bisht²,

Bhandari³

et al. 2012

J. Soil Sci. Plant Nutr.

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Digitalis purpurea and Digitalis lanata are commonly used in treatment of heart diseases, the species has recently introduced for cultivation in the state of Uttarakhand, India. The mineral contents of cultivated plants of these species have to be within permissible limit for its effectiveness. Using inductively coupled plasma mass spectrometry (ICP-MS), this paper describes analysis of selected minerals -1 , respectively. The study reports that the mineral contents were well within the permissible range for medicinal uses. Therefore, the species are recommended for large scale cultivation.

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“…The results (mean ± SD, in grams/100 g) obtained in the ash and humidity tests for Cg were 3.67 ± 0.48 and 11.47 ± 1.02, respectively. The high ash content found in Cg powder indicates the presence of inorganic compounds due to the soil composition, although no correlation between elemental composition of medicinal plants and their curative properties have been established (38). The humidity level found for Cg powder confirms that no enzymatic reaction occurred during sample collection.…”

Section: Resultsmentioning

confidence: 68%

Bothrops jararacussu venom-induced neuromuscular blockade inhibited by Casearia gossypiosperma Briquet hydroalcoholic extract

Camargo¹,

Nazato²,

Silva³

et al. 2010

J. Venom. Anim. Toxins incl. Trop. Dis

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Abstract:The hydroalcoholic extract of Casearia gossypiosperma Briquet (Flacourtiaceae) was standardized for the first time through quality control procedures including pharmacognostic methods, fingerprint chromatograms, defined amounts of marker substances and physicochemical characteristics. The pharmacological activity of C. gossypiosperma (Cg) hydroalcoholic extract was assayed by a traditional in vitro test, which involved irreversible neuromuscular blockade induced by Bothrops jararacussu (Bjssu) venom (60 μg/mL) in mouse phrenic nerve-diaphragm preparations. Bjssu venom blocked muscle activity for 26 (± 2.0) minutes (n = 6). Cg extract (0.1 mg/mL) induced changes on the baseline muscle activity without impairing the muscle function and inhibited 87.6% (± 1.8) (n = 6) of the Bjssu venom-induced blockade. Both flavonoids (0.624 g%) and polyphenols (4.63 g%) from the extract were spectrophotometrically quantified. Therefore, the present study confirms the antibothropic activity of Cg extract, supporting the ethnomedical use of Casearia sp. in the treatment of snakebite victims.Key words: antibothropic extract, Bothrops jararacussu, Casearia gossypiosperma Briquet, snake venoms. pharmacologically assessed for the first time. Original PaPer The Journal of Venomous Animals and Toxins including Tropical DiseasesIn vivo myotoxic effects and in vitro irreversible neuromuscular blockade effects of crude venom from the snake Bothrops jararacussu are well known pharmacological methods used to study drugs showing antivenom properties (29,30). Thus, the aim of the present study was to verify the capability of Casearia gossypiosperma hydroalcoholic extract to neutralize the neuromuscular blockade induced by Bothrops jararacussu venom. MATERIALS AND METHODS Plant Material and ExtractionLeaves from an adult C. gossypiosperma Briquet (Cg) tree were collected from the herbarium at the Higher School of Agriculture Luiz de Queiroz (ESALQ) of the University of São Paulo, Piracicaba, São Paulo, Brazil, in January 2006; the species was previously identified in 1988 (protocol IAC 38115). Cg leaves were dried at 35°C to 40°C for 24 hours. The dried leaves were then powdered, ground in a mill, macerated (200 g, during five days) in 2 L of 70% ethanol and the suspension was percolated (under protection against light) at 20 drops/minute, resulting in a 10% (m/v) hydroalcoholic extract. Quality Control Assays of the Medicinal Plants Ash and humidity testsTo observe elementary physical and chemical characteristics, Cg powder was subjected to ash and humidity tests (31). Briefly, 100 g of the specimen powder were placed in six calibrated melting pots, which were warmed until total carbonization of the powders. The melting pots were kept at 650°C and the ashes were then weighed. Results are expressed as grams of ashes/100 g of sample. The humidity test was performed by placing 1 g of specimen powder in six calibrated porcelain capsules, which were heated at 105ºC during four hours and then weighed. Thin Layer Chromatography (TLC)Aliquots...

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Characterization of trace elements in Casearia medicinal plant by neutron activation analysis

Cited by 51 publications

References 20 publications

Determination of metals in medicinal plants highly consumed in Brazil

Determination of metals in medicinal plants highly consumed in Brazil

Determination of mineral contents of Digitalis purpurea L. and Digitalis lanata Ehrh

Bothrops jararacussu venom-induced neuromuscular blockade inhibited by Casearia gossypiosperma Briquet hydroalcoholic extract

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