Characterization of thymic masses using 18F-FDG PET-CT

Kumar, Arvind; Regmi, Subodh; Dutta, Rimlee; Kumar, Rakesh; Gupta, Siddhartha Datta; Das, Prasenjit; Halanaik, Dhanapathi; Jindal, Tarun

doi:10.1007/s12149-009-0283-z

Cited by 80 publications

(57 citation statements)

References 17 publications

(22 reference statements)

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“…However, in our study an increasing tendency of heterogeneous 18 F-FDG uptake pattern was seen in the order: less-invasive to more-invasive thymoma to thymic carcinoma. Our results were similar to that of Kumar et al [17], who observed that a higher proportion of patch uptake was seen in thymic carcinoma than in high-risk thymomas or low-risk thymomas. Moreover, CT scans of thymic epithelial tumors showed that types A and AB thymomas were round, whereas most type B thymomas were flat with an irregular surface or lobulation [18].…”

Section: Discussionsupporting

confidence: 92%

18F-FDG PET/CT is Useful for Pretreatment Assessment of the Histopathologic Type of Thymic Epithelial Tumors

Kim

et al. 2010

Nucl Med Mol Imaging

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Section: Discussionsupporting

confidence: 92%

18F-FDG PET/CT is Useful for Pretreatment Assessment of the Histopathologic Type of Thymic Epithelial Tumors

Kim

et al. 2010

Nucl Med Mol Imaging

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“…In the investigation of 18 F-FDG PET in thymic epithelial tumors, several researchers described that 18 F-FDG uptake on PET can help predict the grade of malignancy and staging in thymic epithelial tumors [5,[17][18][19]. Recently, we reported that 18 F-FDG uptake is closely associated with outcome and is determined by the presence of glucose metabolism, hypoxia, angiogenesis and cell cycle regulator [5].…”

Section: Discussionmentioning

confidence: 99%

18F-FDG uptake on PET helps predict outcome and response after treatment in unresectable thymic epithelial tumors

et al. 2010

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“…FDG uptake has also been shown to be increased in the thymus in adults after chemotherapy [1,11]. Kumar et al [12] analyzed 23 patients with anterior mediastinal masses suspicious of thymic origin on CT scan and then all patients underwent PET-CT. According to the level of FDG uptake, the pattern of uptake, the presence of invasion to surrounding structures or metastases, thymic hyperplasia, thymoma and thymic carcinoma were considered in the differential diagnosis, and these diagnoses were supported histopathologically.…”

Section: Discussionmentioning

confidence: 99%

The role of PET-CT in the differential diagnosis of thymic mass after treatment of patients with lymphoma

et al. 2010

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Thymic hyperplasia is a common phenomenon in both children and young adults after chemotherapy and may explain the finding of a mediastinal mass in patients with malignant lymphoma after complete remission. In the present study, we report 5 cases with malignant lymphoma presenting with a mediastinal mass on CT scan after completion of chemotherapy diagnosed as thymic hyperplasia by PET-CT imaging. We retrospectively analyzed 5 patients who presented with anterior mediastinal masses a median of 4 months (range 3-6) after achieving complete remission following successful treatment for malignant lymphoma. Three patients were diagnosed with Hodgkin's lymphoma (HL) and the others with non-Hodgkin's lymphoma (NHL). The median age of the patients was 23 (range of 18-47). PET-CT was performed on these patients to determine the characteristics of a mass which had been detected on CT. PET-CT was performed for all patients, and the thymic masses demonstrated only mild FDG uptake considered to be consistent with thymic hyperplasia. During a median of 24 months of follow-up, all patients were recurrence-free with a median survival of 15 months (range 10-26 months). It is important to be aware of the possibility of thymic hyperplasia after chemotherapy to avoid misdiagnosis or over-staging of disease, as well as unnecessary biopsies, especially when the presenting anterior mediastinal mass was originally located near the thymus on CT scan. Mild FDG PET uptake was sufficient for the diagnosis of benign disease in the cases in this study.

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Characterization of thymic masses using 18F-FDG PET-CT

Abstract: (18)F-FDG PET-CT can help characterize various thymic lesions noted on conventional imaging modalities. However, larger prospective studies are further required to substantiate these findings.

Cited by 80 publications

References 17 publications

18F-FDG PET/CT is Useful for Pretreatment Assessment of the Histopathologic Type of Thymic Epithelial Tumors

18F-FDG PET/CT is Useful for Pretreatment Assessment of the Histopathologic Type of Thymic Epithelial Tumors

18F-FDG uptake on PET helps predict outcome and response after treatment in unresectable thymic epithelial tumors

The role of PET-CT in the differential diagnosis of thymic mass after treatment of patients with lymphoma

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