Characterization of three dimensional volumetric strain distribution during passive tension of the human tibialis anterior using Cine Phase Contrast MRI

Abstract

Intramuscular pressure correlates strongly with muscle tension and is a promising tool for quantifying individual muscle force. However, clinical application is impeded by measurement variability that is not fully understood. Previous studies point to regional differences in IMP, specifically increasing pressure with muscle depth. Based on conservation of mass, intramuscular pressure and volumetric strain distributions may be inversely related. Therefore, we hypothesized volumetric strain would decrease with muscle depth. To test this we quantified 3D volumetric strain in the tibialis anterior of 12 healthy subjects using cine Phase Contrast Magnetic Resonance Imaging. Cine Phase Contrast data were collected while a custom apparatus rotated the subjects’ ankle continuously between neutral and plantarflexion. A T2-weighted image stack was used to define the resting tibials anterior position. Custom and commercial post-processing software were used to quantify the volumetric strain distribution. To characterize regional strain changes, the muscle was divided into superior-inferior sections and either medial-lateral or anterior-posterior slices. Mean volumetric strain was compared across the sections and slices. As hypothesized, volumetric strain demonstrated regional differences with a decreasing trend from the anterior (superficial) to the posterior (deep) muscle regions. Statistical tests showed significant main effects and interactions of superior-inferior and anterior-posterior position as well as superior-inferior and medial-lateral position on regional strain. These data support our hypothesis and imply a potential relationship between regional volumetric strain and intramuscular pressure. This finding may advance our understanding of intramuscular pressure variability sources and lead to more reliable measurement solutions in the future.

An experimental and computational investigation of the effects of volumetric boundary conditions on the compressive mechanics of passive skeletal muscle

“…To minimize tissue damage, high profile histology blades and surgical scalpels were used for dissection. These geometries, in accordance with previous literature [59],…”

3D Muscle Deformation Mapping at Submaximal Isometric Contractions: Applications to Aging Muscle

“…In the current work, implementation of the fast CS VE-PC sequence enabled multi-slice, 3 directional VE-PC acquisitions of sufficiently short duration that it could be tolerated even by the senior cohort. Jensen et al (2015Jensen et al ( , 2016 used sequential acquisition of 2D slices with velocity encoded phase contrast acquisition to compute the volumetric strain tensor under condition of passive plantarflexion. The latter papers noted that acquisition of multi-slice, 3 directional data under conditions of dynamic contractions (e.g., isometric) is more challenging than passive motion due to the requirement of a large number of consistent contractions and suggested the use of faster sequences.…”

Evaluate muscle tension using intramuscular pressure device in rabbit tibialis anterior model for improved tendon transfer surgery

“…Jensen et al developed a technique to evaluate strain with cine phase contrast MRI (Jensen et al 2015a, 2015b) in order to investigate the relationship between strain and IMP. Early findings using these techniques reveal the mid-belly of the human TA had the most uniform strain and will result in the most reliable pressure recordings (Jensen et al 2016). Therefore we suggest inserting the sensor in the muscle mid-belly to half depth and avoid tendon insertions.…”