Characterization of three different types of extracellular vesicles and their impact on bacterial growth

Yu, Siran; Xu, Xiaoyan; Li, Min; Li, Ping

doi:10.1016/j.foodchem.2018.08.059

Cited by 64 publications

(71 citation statements)

References 40 publications

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“…Multiple studies have since then validated this new paradigm, demonstrating that microRNAs are long‐range gene regulators exchanged by all cell types in humans and other mammals and that have tremendous impact on health and disease (Meldolesi, ; Zhang et al., ). Circulating microRNAs can regulate the immune system (Robbins & Morelli, ), promote or prevent cancer development (Azmi, Bao, & Sarkar, ), impact brain development and functions (Janas, Sapoń, Janas, Stowell, & Janas, ; Xin et al., ), and allow communication with bacteria (Yu, Zhao, Xu, Li, & Li, ) especially with those of the gut microbiota (Liu et al., ; Yu et al., ).…”

Section: Circulating Micrornas: the Paradigm Shiftmentioning

confidence: 99%

“…According to more than 30 studies, from different teams around the world, milk EVs resisted in vitro digestion (Benmoussa et al., ; Kahn et al., ; Liao et al., ; Rani et al., ; Shandilya et al., ; Vashisht et al., ) were internalized by recipient cells upon co‐incubation (Admyre et al., , 2008; Aqil et al., , ; Badawy et al., ; Golan‐Gerstl et al., ; Hock et al., ; Kahn et al., ; Liao et al., ; Maburutse, Park, Oh, & Kim, ; Martin et al., ; Matsuda & Patel, ; Mobley et al., ; Munagala et al., ; Naslund et al., ; Qin et al., ; Vashisht, Rani, Onteru, & Singh, ; Yu et al., ), transduced through the intestinal wall in vitro (Rani et al., ; Shandilya et al., ; Wolf et al., ), and were detected in animal models after ingestion (Manca et al., ; Munagala et al., ) or intravenous injection (Somiya, Yoshioka, & Ochiya, ).…”

Section: Milk Micrornas In Health and Diseasementioning

confidence: 99%

“…Twenty‐one studies involving milk EVs from humans, rat, camels, and most often cow milks reported milk EVs bioactivity in vitro on cells (Admyre et al., ; Aqil et al., , ; Badawy et al., ; Golan‐Gerstl et al., ; Hock et al., ; Martin et al., ; Matsuda & Patel, ; Mobley et al., ; Munagala et al., ; Naslund et al., ; Qin et al., ; Vashisht et al., ; Yu et al., ) and in vivo in animal models (Agrawal et al., ; Aqil et al., , ; Badawy et al., ; Leiferman et al., ; Munagala et al., ; Munagala et al., ; Somiya et al., ).…”

Section: Milk Micrornas In Health and Diseasementioning

confidence: 99%

“…Functionality of milk EVs has been explored following their intrinsic biological activity or their potential as drug carriers for cancer treatment (Agrawal et al., ; Aqil et al., , ; Badawy et al., ; Munagala et al., , ; Qin et al., ; Somiya et al., ), for the modulation of inflammation (Admyre et al., ; Arntz et al., ; Badawy et al., ; Martin et al., ; Vashisht et al., ), for gut, bone, and muscle development (Chen et al., ; Hock et al., ; Leiferman et al., ; Martin et al., ; Mobley et al., ; Oliveira et al., , ), bacterial proliferation (Yu et al., ), and in the prevention of HIV infection (Naslund et al., ).…”

Section: Milk Micrornas In Health and Diseasementioning

confidence: 99%

“…The major organs which are responsible for milk EV uptake are likely the liver, spleen, and lung, and the small intestine, through immune cells (Zempleni, 2017) with a potential uptake of milk EVs by the gut microbiota (Yu et al, 2019;Zempleni, 2017). Notably, milk EVs reached the brain of mice after oral administration (Manca et al, 2018).…”

Section: Milk Evs: Functional Carriers Of Micrornasmentioning

confidence: 99%

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Milk MicroRNAs in Health and Disease

Benmoussa

Provost

2019

Comp Rev Food Sci Food Safe

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MicroRNAs are small noncoding RNAs responsible for regulating 40% to 60% of gene expression at the posttranscriptional level. The discovery of circulating microRNAs in several biological fluids opened the path for their study as biomarkers and long‐range cell‐to‐cell communication mediators. Their transfer between individuals in the case of blood transfusion, for example, and their high enrichment in milk have sparked the interest for microRNA transfer through diet, especially from mothers to infants during breastfeeding. The extension of such paradigm led to the study of milk microRNAs in the case of cow or goat milk consumption in adults. Here we provide a comprehensive critical review of the key findings surrounding milk microRNAs in human, cow, and goat milk among other species. We discuss the data on their biological properties, their use as disease biomarkers, their transfer between individuals or species, and their putative or verified functions in health and disease of infants and adult consumers. This work is based on all the literature available and integrates all the results, theories, debates, and validation studies available so far on milk microRNAs and related areas of investigations. We critically discuss the limitations and outline future aspects and avenues to explore in this rapidly growing field of research that could impact public health through infant milk formulations or new therapies. We hope that this comprehensive review of the literature will provide insight for all teams investigating milk RNAs’ biological activities and help ensure the quality of future reports.

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Section: Circulating Micrornas: the Paradigm Shiftmentioning

confidence: 99%

Section: Milk Micrornas In Health and Diseasementioning

confidence: 99%

Section: Milk Micrornas In Health and Diseasementioning

confidence: 99%

Section: Milk Micrornas In Health and Diseasementioning

confidence: 99%

Section: Milk Evs: Functional Carriers Of Micrornasmentioning

confidence: 99%

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Milk MicroRNAs in Health and Disease

Benmoussa

Provost

2019

Comp Rev Food Sci Food Safe

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Therapeutic Potential of Extracellular Vesicles from Different Cell Sources

Wang,

2023

Biomedical Applications of Extracellular Vesicles

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Extracellular Vesicle Preparation and Analysis: A State‐of‐the‐Art Review

Wang,

Zhou,

Kong

et al. 2024

Advanced Science

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In recent decades, research on Extracellular Vesicles (EVs) has gained prominence in the life sciences due to their critical roles in both health and disease states, offering promising applications in disease diagnosis, drug delivery, and therapy. However, their inherent heterogeneity and complex origins pose significant challenges to their preparation, analysis, and subsequent clinical application. This review is structured to provide an overview of the biogenesis, composition, and various sources of EVs, thereby laying the groundwork for a detailed discussion of contemporary techniques for their preparation and analysis. Particular focus is given to state‐of‐the‐art technologies that employ both microfluidic and non‐microfluidic platforms for EV processing. Furthermore, this discourse extends into innovative approaches that incorporate artificial intelligence and cutting‐edge electrochemical sensors, with a particular emphasis on single EV analysis. This review proposes current challenges and outlines prospective avenues for future research. The objective is to motivate researchers to innovate and expand methods for the preparation and analysis of EVs, fully unlocking their biomedical potential.

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Characterization of three different types of extracellular vesicles and their impact on bacterial growth

Cited by 64 publications

References 40 publications

Milk MicroRNAs in Health and Disease

Milk MicroRNAs in Health and Disease

Therapeutic Potential of Extracellular Vesicles from Different Cell Sources

Extracellular Vesicle Preparation and Analysis: A State‐of‐the‐Art Review

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