Characterization of the wheat-<i>Stagonospora nodorum</i>disease system: what is the molecular basis of this quantitative necrotrophic disease interaction?<sup>†</sup>

Friesen, Timothy L.; Faris, Justin D.

doi:10.1080/07060661003620896

Cited by 81 publications

(78 citation statements)

References 54 publications

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“…Indeed, SnTox1, SnToxA, as well as SnTox3, all have similar expression patterns with transcript abundance peaking at 3 days post inoculation (dpi), which correlates with the onset of necrosis development (Liu et al, 2009(Liu et al, , 2012Faris et al, 2011). A wheat recombinant inbred population segregating for Snn2 and Tsn1 (ToxA sensitivity) showed that the SnTox2-Snn2 interaction accounts for 47%, while the SnToxA-Tsn1 interaction accounts for 20% of the disease variation (Friesen & Faris, 2010). Comparative analysis of the infection process between nonpathogenic and pathogenic isolates of S. nodorum has shown that SnTox1 plays a significant role during the initial penetration process.…”

Section: Proteinaceous Hsts Produced By Dothideomycetesmentioning

confidence: 99%

Phytotoxic secondary metabolites and peptides produced by plant pathogenicDothideomycetefungi

Stergiopoulos¹,

Collemare²,

Mehrabi³

et al. 2013

FEMS Microbiol Rev

167

103

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Many necrotrophic plant pathogenic fungi belonging to the class of Dothideomycetes produce phytotoxic metabolites and peptides that are usually required for pathogenicity. Phytotoxins that affect a broad range of plant species are known as non-host-specific toxins (non-HSTs), whereas HSTs affect only a particular plant species or more often genotypes of that species. For pathogens producing HSTs, pathogenicity and host specificity are largely defined by the ability to produce the toxin, while plant susceptibility is dependent on the presence of the toxin target. Non-HSTs are not the main determinants of pathogenicity but contribute to virulence of the producing pathogen. Dothideomycetes are remarkable for the production of toxins, particularly HSTs because they are the only fungal species known so far to produce them. The synthesis, regulation, and mechanisms of action of the most important HSTs and non-HSTs will be discussed. Studies on the mode of action of HSTs have highlighted the induction of programed cell death (PCD) as an important mechanism. We discuss HST-induced PCD and the plant hypersensitive response upon recognition of avirulence factors that share common pathways. In this respect, although nucleotide-binding-site-leucine-rich repeat types of resistance proteins mediate resistance against biotrophs, they can also contribute to susceptibility toward necrotrophs.

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Section: Proteinaceous Hsts Produced By Dothideomycetesmentioning

confidence: 99%

Phytotoxic secondary metabolites and peptides produced by plant pathogenicDothideomycetefungi

Stergiopoulos¹,

Collemare²,

Mehrabi³

et al. 2013

FEMS Microbiol Rev

167

103

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“…However, because the pathogen is a necrotroph, the end result was susceptibility as opposed to resistance. Therefore, this work demonstrated that the pathogen acquired the ability to hijack the host’s own ETI pathway, resulting in NE-triggered susceptibility (NETS) ( 10 ). …”

Section: Introductionmentioning

confidence: 99%

The hijacking of a receptor kinase–driven pathway by a wheat fungal pathogen leads to disease

et al. 2016

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“…The lack of NE recognition by the host leads to resistance. Therefore, these host–pathogen interactions operate in an inverse gene-for-gene manner (Wolpert et al 2002; Friesen and Faris 2010; Oliver et al 2012; Faris et al 2013), and the dominant alleles of the host NE recognition genes are considered susceptibility genes.…”

mentioning

confidence: 99%

New Insights into the Roles of Host Gene-Necrotrophic Effector Interactions in Governing Susceptibility of Durum Wheat to Tan Spot and Septoria nodorum Blotch

Virdi

Liu

Overlander

et al. 2016

G3 Genes|Genomes|Genetics

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Tan spot and Septoria nodorum blotch (SNB) are important diseases of wheat caused by the necrotrophic fungi Pyrenophora tritici-repentis and Parastagonospora nodorum, respectively. The P. tritici-repentis necrotrophic effector (NE) Ptr ToxB causes tan spot when recognized by the Tsc2 gene. The NE ToxA is produced by both pathogens and has been associated with the development of both tan spot and SNB when recognized by the wheat Tsn1 gene. Most work to study these interactions has been conducted in common wheat, but little has been done in durum wheat. Here, quantitative trait loci (QTL) analysis of a segregating biparental population indicated that the Tsc2-Ptr ToxB interaction plays a prominent role in the development of tan spot in durum. However, analysis of two biparental populations indicated that the Tsn1-ToxA interaction was not associated with the development of tan spot, but was strongly associated with the development of SNB. Pa. nodorum expressed ToxA at high levels in infected Tsn1 plants, whereas ToxA expression in P. tritici-repentis was barely detectable, suggesting that the differences in disease levels associated with the Tsn1-ToxA interaction were due to differences in pathogen expression of ToxA. These and previous results together indicate that: (1) the effects of Tsn1-ToxA on tan spot in common wheat can range from nonsignificant to highly significant depending on the host genetic background; (2) Tsn1-ToxA is not a significant factor for tan spot development in durum wheat; and (3) Tsn1-ToxA plays a major role in SNB development in both common and durum wheat. Durum and common wheat breeders alike should strive to remove both Tsc2 and Tsn1 from their materials to achieve disease resistance.

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Characterization of the wheat-Stagonospora nodorumdisease system: what is the molecular basis of this quantitative necrotrophic disease interaction?^†

Cited by 81 publications

References 54 publications

Phytotoxic secondary metabolites and peptides produced by plant pathogenicDothideomycetefungi

Phytotoxic secondary metabolites and peptides produced by plant pathogenicDothideomycetefungi

The hijacking of a receptor kinase–driven pathway by a wheat fungal pathogen leads to disease

New Insights into the Roles of Host Gene-Necrotrophic Effector Interactions in Governing Susceptibility of Durum Wheat to Tan Spot and Septoria nodorum Blotch

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Characterization of the wheat-Stagonospora nodorumdisease system: what is the molecular basis of this quantitative necrotrophic disease interaction?†

Cited by 81 publications

References 54 publications

Phytotoxic secondary metabolites and peptides produced by plant pathogenicDothideomycetefungi

Phytotoxic secondary metabolites and peptides produced by plant pathogenicDothideomycetefungi

The hijacking of a receptor kinase–driven pathway by a wheat fungal pathogen leads to disease

New Insights into the Roles of Host Gene-Necrotrophic Effector Interactions in Governing Susceptibility of Durum Wheat to Tan Spot and Septoria nodorum Blotch

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Characterization of the wheat-Stagonospora nodorumdisease system: what is the molecular basis of this quantitative necrotrophic disease interaction?^†