Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol

Yamaori, Satoshi; Okushima, Yoshimi; Yamamoto, Ikuo; Watanabe, Kazuhito

doi:10.1016/j.cbi.2014.03.007

Cited by 24 publications

(12 citation statements)

References 29 publications

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“…The structural analogies of the catalytic site of these two cytochromes explain their common substrates [166]. CBD seems to present the highest inhibitory power; however, no in vivo study supports the relevance of these experimental results [56,167,168]. Table III, many anticancer agents are also UGT substrates.…”

Section: Cyp2c9mentioning

confidence: 99%

Cannabis and anticancer drugs: societal usage and expected pharmacological interactions – a review

Bouquié

Deslandes

Mazaré

et al. 2018

Fundamemntal Clinical Pharma

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Cannabis is a plant that has been used for centuries to relieve a wide range of symptoms. Since the 1960s, interest in medical research into this plant has grown steadily. Already very popular for recreational use, a growing number of consumers not accustomed to using cannabis for psychoactive purposes have begun to use it as an alternative or complement to mainstream pharmaceutical medicines. The principal unsubstantiated or 'social' uses of cannabis are based mainly on data that is at best controversial, but usually not scientifically proven. The aim of this review was to identify the scientific basis and reasons that lead patients with cancer to consume cannabis, and also to identify whether there is a risk of interaction between cannabis and anticancer medicines through drug transporters (P-glycoprotein and other ATP-binding cassette superfamily members) Cytochromes P450 (3A, 1A, 2B, 2C, 2D families…) and glucuronyl transferases.

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Section: Cyp2c9mentioning

confidence: 99%

Cannabis and anticancer drugs: societal usage and expected pharmacological interactions – a review

Bouquié

Deslandes

Mazaré

et al. 2018

Fundamemntal Clinical Pharma

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“…Data from a total of 22 published in vitro reports focusing on cannabis-drug interactions were entered into the repository (Holland et al, 2006(Holland et al, , 2007(Holland et al, , 2008Zhu et al, 2006;Watanabe et al, 2007;Mazur et al, 2009;Alhamoruni et al, 2010;Tournier et al, 2010;Yamaori et al, 2010Yamaori et al, , 2011aYamaori et al, ,b, 2012Yamaori et al, , 2013Yamaori et al, , 2014Yamaori et al, , 2015Jiang et al, 2011Jiang et al, , 2013Arnold et al, 2012;Al Saabi et al, 2013;Feinshtein et al, 2013a,b;Qian et al, 2019). As Figure 4 shows, experiments using either human liver microsomes or recombinant baculovirus-transfected insect cells expressing specific P450/UGT isoforms reported that cannabinoids inhibit CYP1A1, CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4/5, and UGT (Mazur et al, 2009;Yamaori et al, 2010Yamaori et al, , 2011aYamaori et al, ,b, 2012Yamaori et al, , 2013Al Saabi et al, 2013;Jiang et al, 2013;Qian et al, 2019).…”

Section: Utilitymentioning

confidence: 99%

A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: From Chemical Characterization to Clinical Studies

et al. 2020

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There are many gaps in scientific knowledge about the clinical significance of pharmacokinetic natural product-drug interactions (NPDIs) in which the natural product (NP) is the precipitant and a conventional drug is the object. The National Center for Complimentary and Integrative Health created the Center of Excellence for NPDI Research (NaPDI Center) (www.napdi.org) to provide leadership and guidance on the study of pharmacokinetic NPDIs. A key contribution of the Center is the first user-friendly online repository that stores and links pharmacokinetic NPDI data across chemical characterization, metabolomics analyses, and pharmacokinetic in vitro and clinical experiments (repo.napdi.org). The design is expected to help researchers more easily arrive at a complete understanding of pharmacokinetic NPDI research on a particular NP. The repository will also facilitate multidisciplinary collaborations, as the repository links all of the experimental data for a given NP across the study types. The current work describes the design of the repository, standard operating procedures used to enter data, and pharmacokinetic NPDI data that have been entered to date. To illustrate the usefulness of the NaPDI Center repository, more details on two high-priority NPs, cannabis and kratom, are provided as case studies. SIGNIFICANCE STATEMENT The data and knowledge resulting from natural product-drug interaction (NPDI) studies is distributed across a variety of information sources, rendering difficulties to find, access, and reuse. The Center of Excellence for NPDI Research addressed these difficulties by developing the first user-friendly online repository that stores data from in vitro and clinical pharmacokinetic NPDI experiments and links them with study data from chemical characterization and metabolomics analyses of natural products that are also stored in the repository.

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“…7: Illustrate the deferent between C3-, C4-and CAM-type plants due to the differential Physiological and enzymatic carbon fixation processes. (After Yamaori et al (2014).…”

Section: -Silicon In Plant Biology Under Stress Conditionmentioning

confidence: 99%

Function of silicon and its mechanisms in plant physiology: A review

2019

Middle East J. Agric. Res.

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Silicon (Si) is the most prevalent macroelements in soil, performing an essential function in healing plants in response to environmental stresses. The assumption of the depletion of plant available-Si is still admissible, but new evident have establish that phytoliths are a denoting derivation of Silicon for plant growth. Biotic and abiotic stress factors can adversely affect the agricultural productivity pleading to physiological and biochemical damage to crops. Therefore, the most effective way to overcome such negative effects is to increase the resistance to stresses. Silicon plays a vital role in reducing the negative effects of abiotic and biotic stresses on plants. Silicon is accumulated in the cell walls and intercellular spaces and increase its strength, and thus it has beneficial effects on disease infestations in especially small grains. In addition, application of silicon may reduce the effects of environmental stresses on plants while making effective use of plant nutrients such as nitrogen and phosphorous. Reducing, the toxic effects of heavy metals in soil. It may protect the foliage and increase light uptake and reduce respiration. However, the concentration of Si depends on the plants genotype and organisms. Physiological mechanisms and metabolic activities of plants may affected by Si treatment. Generally, plant physiologists consider an essential element by two criteria. (a): if a deficiency of it makes it impossible for the plant to complete its life cycle, therefore, the element must be directly involved in the inorganic nutrition of the plant. (b): it is contributed as a part of the molecule of an essential plant constituent or metabolite. It is by the first criterion that the essentiality of the elements now known to be essential has been established. Conceptually, it is a simple, operational definition. In practice, it is not necessarily easy to apply if, as is the case with Si, it is difficult to create and maintain an environment adequately purged of the element. Peptides as well as amino acids can effectively create polysilicic species through interactions with different species of silicate inside solution. The carboxylic acid and the alcohol groups of serine and asparagine tend not to engage in any significant role in polysilicates formation, but the hydroxyl group side chain can be involved in the formation of hydrogen bond with Si (OH) 4. The mechanisms and trend of Si absorption are different between plant species. Furthermore, the transportation of Si requires an energy mechanism; thus, low temperatures and metabolic repressors inhibit Si transportation.

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Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol

Cited by 24 publications

References 29 publications

Cannabis and anticancer drugs: societal usage and expected pharmacological interactions – a review

Cannabis and anticancer drugs: societal usage and expected pharmacological interactions – a review

A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: From Chemical Characterization to Clinical Studies

Function of silicon and its mechanisms in plant physiology: A review

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