1982
DOI: 10.1210/jcem-55-3-434
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Characterization of the Somatomedin-C/Insulin-Like Growth Factor I (SM-C/IGF-I) Receptor on Cultured Human Fibroblast Monolayers: Regulation of Receptor Concentrations by SM-C/IGF-I and Insulin*

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Cited by 160 publications
(62 citation statements)
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“…Twelve of 23 GDIgG preparations tested in that earlier study significantly displaced binding regardless of whether the donor manifested clinical TAO. The K d of IGF-I binding was 0.5 nM (46), consistent with that found in dermal fibroblasts (35). These earlier studies failed to identify the IGF-I binding site in fibroblasts.…”
Section: Discussionsupporting
confidence: 70%
See 1 more Smart Citation
“…Twelve of 23 GDIgG preparations tested in that earlier study significantly displaced binding regardless of whether the donor manifested clinical TAO. The K d of IGF-I binding was 0.5 nM (46), consistent with that found in dermal fibroblasts (35). These earlier studies failed to identify the IGF-I binding site in fibroblasts.…”
Section: Discussionsupporting
confidence: 70%
“…These effects of disease-specific Igs can now be attributed to interactions with IGF-IR, which is widely expressed on human fibroblasts (35). Activating TSHR with TSH fails to elicit these responses.…”
Section: Discussionmentioning
confidence: 99%
“…The finding of slightly higher levels of IGF-I binding in the liver of feed-restricted gilts is consistent with the increase in IGF-IR in some tissues in response to fasting or protein deprivation [16,35] and with data showing that IGF-I down-regulates its own receptor in vitro [29,30]. The lack of alteration of IGF-I binding in skeletal muscle and adipose tissue despite changes in plasma IGF-I concentration does not corroborate this relationship.…”
Section: Discussionsupporting
confidence: 61%
“…Thus, the potential for growth factors and their cognate cell surface receptors to participate in this disease appears great. IGF-1R is a ubiquitous protein expressed on many cell types, including human fibroblasts (23). When ligated, the tyrosine kinase receptor initiates signaling leading to multiple cell responses, including those resulting in proliferation (24).…”
Section: Induction Of Il-16 and Rantes Expression In Ra Synovial Fibrmentioning
confidence: 99%