Characterization of the sensitivity of cardiac outwardly-rectifying K+ channels to class III antiarrhythmics: the influence of inhibitory sulfonamide derivatives
Abstract:Elementary K+ currents through cardiac 66 pS outwardly-rectifying K+ channels isolated from cultured neonatal rat cardiocytes were recorded in the inside-out patch configuration. By analyzing the influence of inhibitory sulfonamide derivatives, the block phenomenology evoked by these class III antiarrhythmic drugs was studied. After isolation from their cellular environment, K+(outw.-rect.) channels became usually upregulated so that open probability increased with time to reach, within 3 min or longer, a seve… Show more
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