Characterization of the Retinal Changes of the 3xTg-AD Mouse Model of Alzheimer’s Disease

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose diagnosis remains a notable challenge. The literature suggests that cerebral changes precede AD symptoms by over two decades, implying a significantly advanced stage of AD by the time it is usually diagnosed. In the study herein, texture analysis was applied to computed optical coherence tomography ocular fundus images to identify differences between a group of the transgenic mouse model of the Alzheimer's disease (3×Tg-AD) and a group of wild-type mice, at the ages of one and two-monthsold. A substantial difference between groups was found at both time-points across all neuroretina's layers. Here, the inner nuclear layer stands out both in the level of statistically significant differences and on the extension of these differences which span through the imaged area. Also, the progression of AD is suggested to be spotted by

The Effect of Menopause on the Sexual Dimorphism in the Human Retina – Texture Analysis of Optical Coherence Tomography Data

“…Recently, our group has been applying texture analysis to OCT data to gain further insight on the differences in the retinal structure, between distinct healthy control groups [23] and between healthy individuals and patients diagnosed with several neurodegenerative disorders, namely Alzheimer's and Parkinson's diseases [25] and multiple sclerosis [24]. Furthermore, the same analysis methodology was applied to animal studies, in which OCT data from a mouse model of AD and control mice groups were examined [22,10]. These studies further confirmed the power of texture analysis to unveil information from OCT data, yet unexplored.…”