Characterization of the quorum quenching activity of Streptomyces minutiscleroticus: A new approach for infection control

Sakr, Masarra M.; Aboshanab, Khaled M.; Aboulwafa, Mohammad M.; Hassouna, Nadia A.

doi:10.5897/ajmr2014.7316

Cited by 4 publications

(3 citation statements)

References 30 publications

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Section: In Planta Approaches For Biocontrol and Specialised...mentioning

confidence: 99%

“…Subsequently, they used the biosensor platform to investigate how interactions within the Pseudomonas genus specifically affected the production of DAPG and induced or suppressed plantbeneficial activities in other rhizobacteria (Hansen et al, 2022). Similarly, Masarra et al (2015) used a Chromobacterium violaceum mutant that produces the pigment violacein in response to quorum sensing molecules as a 'native' biosensor to screen a library of 63 soil-isolated Streptomyces isolates for metabolites with quorum quenching activity. Finally, Chane et al (2019) developed a biosensor to monitor quorum signal molecule detection or degradation in the Actinobacteria biocontrol Rhodococcus erythropolis in response to co-inoculation onto potato tubers with the soft rot pathogen Pectobacterium atrosepticum.…”

Section: Biosensors As Direct or Indirect Reporters Of Mbca And Speci...mentioning

confidence: 99%

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Streptomyces and their specialised metabolites for phytopathogen control – comparative in vitro and in planta metabolic approaches

et al. 2023

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In the search for new crop protection microbial biocontrol agents, isolates from the genus Streptomyces are commonly found with promising attributes. Streptomyces are natural soil dwellers and have evolved as plant symbionts producing specialised metabolites with antibiotic and antifungal activities. Streptomyces biocontrol strains can effectively suppress plant pathogens via direct antimicrobial activity, but also induce plant resistance through indirect biosynthetic pathways. The investigation of factors stimulating the production and release of Streptomyces bioactive compounds is commonly conducted in vitro, between Streptomyces sp. and a plant pathogen. However, recent research is starting to shed light on the behaviour of these biocontrol agents in planta, where the biotic and abiotic conditions share little similarity to those of controlled laboratory conditions. With a focus on specialised metabolites, this review details (i) the various methods by which Streptomyces biocontrol agents employ specialised metabolites as an additional line of defence against plant pathogens, (ii) the signals shared in the tripartite system of plant, pathogen and biocontrol agent, and (iii) an outlook on new approaches to expedite the identification and ecological understanding of these metabolites under a crop protection lens.

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Section: In Planta Approaches For Biocontrol and Specialised...mentioning

confidence: 99%

Section: Biosensors As Direct or Indirect Reporters Of Mbca And Speci...mentioning

confidence: 99%

Streptomyces and their specialised metabolites for phytopathogen control – comparative in vitro and in planta metabolic approaches

et al. 2023

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“…Characterization of quorum quenching activity in 63 Streptomyces soil isolates showed that 3 strains St11, St61 and St62 degraded synthetic hexanoyl homoserine lactone (HHL). The acylase was stable in the presence of heavy metals and chelating agents, and maintained a maximum catalytic activity between 20 to 50°C up to pH 8 (Sakr et al, 2015). The extracts of Streptomyces akiyoshinensis (A3) inhibited Streptococcus pyogenes biofilms at a concentration of 10 to 50 μg/ml.…”

Section: Family: Streptomycetaceae; Genus: Streptomycesmentioning

confidence: 99%

Profile of the Intervention Potential of the Phylum Actinobacteria Toward Quorum Sensing and Other Microbial Virulence Strategies

Sarveswari

Solomon

2019

Front. Microbiol.

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The rapid dissemination of antimicrobial resistance amongst microorganisms and their deleterious effect on public health has propelled the exploration of alternative interventions that target microbial virulence rather than viability. In several microorganisms, the expression of virulence factors is controlled by quorum sensing systems. A comprehensive understanding into microbial quorum sensing systems, virulence strategies and pathogenesis has exposed potential targets whose attenuation may alleviate infectious diseases. Such virulence attenuating natural products sourced from the different phyla of bacteria from diverse ecosystems have been identified. In this review, we discuss chemical entities derived from the phylum Actinobacteria that have demonstrated the potential to inhibit microbial biofilms, enzymes, and other virulence factors both in vivo and in vitro. We also review Actinobacteria-derived compounds that can degrade quorum sensing signal molecules, and the genes encoding such molecules. As many Actinobacteria-derived compounds have been translated into pharmaceutically important agents including antibiotics, the identification of virulence attenuating compounds from this phylum exemplifies their significance as a prospective source for anti-virulent drugs.

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Quorum Sensing and Quorum Quenching Metabolites in Actinomycetes

Bai

Ravishankar

2022

Natural Products From Actinomycetes

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Characterization of the quorum quenching activity of Streptomyces minutiscleroticus: A new approach for infection control

Cited by 4 publications

References 30 publications

Streptomyces and their specialised metabolites for phytopathogen control – comparative in vitro and in planta metabolic approaches

Streptomyces and their specialised metabolites for phytopathogen control – comparative in vitro and in planta metabolic approaches

Profile of the Intervention Potential of the Phylum Actinobacteria Toward Quorum Sensing and Other Microbial Virulence Strategies

Quorum Sensing and Quorum Quenching Metabolites in Actinomycetes

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