Characterization of the Pulmonary Circulation According to Hemodynamic Changes by Computed Tomography

Choi, Byoung Wook; Choe, Kyu Ok; Kim, Hee Joung; Cho, Bum Koo; Chung, Kwansoo; Kim, Se Kyu; Kim, Bong Kyung; Yang, In Sook

doi:10.3349/ymj.2003.44.6.968

Cited by 6 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another source of variation is that PBV varies with work load, 9 venous return and body position, 23 and total blood volume, 7,9 while PTT may vary with variations in regional blood flow in lung lobes caused by gravity and posture, 42–44 the recruitment level of bronchial anastomoses affecting resistance, as well as equal lobe distribution of the tracer 5 and inaccuracy in timing and tightness of the tracer bolus 4,5 . However, we made all FPRNAs in standard positions after resting animals and checking for unbroken boluses.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Blood Volume in Mitral Regurgitation in Cavalier King Charles Spaniels

Eriksson

Hansson

Häggström

et al. 2010

Journal of Veterinary Internal Medicine

View full text Add to dashboard Cite

Background: Pulmonary edema and venous congestion are well-recognized signs of congestive heart failure (CHF) in advanced canine chronic mitral regurgitation (MR). However, little is known about pulmonary blood volume (PBV), blood pulmonary transit time (PTT), and the regulation of these.Objectives: To measure and evaluate the relationships of PBV, forward stroke volume (FSV), and heart rate normalized blood pulmonary transit time (nPTT) in healthy dogs and dogs with MR.Animals: Thirty-three Cavalier King Charles Spaniels; 11 healthy, 4 in modified New York Heart Association (NYHA) class I, 11 in class II, and 7 in CHF.Methods: Heart rate normalized PTTs were measured by radionuclide angiocardiography. Left ventricular end diastolic and systolic diameter, left atrial/aortic root ratio, and FSV were measured by echocardiography. PBV and pulmonary blood volume index (PBVI) were calculated by established formulas.Results: PBVI was 308 AE 56 (mean AE SD) mL/m 2 for healthy dogs, 287 AE 51 mL/m 2 in NYHA class I, 360 AE 66 mL/m 2 in Class II, and 623 AE 232 mL/m 2 in CHF (P 5 .0008). Heart rate normalized PTT, not FSV, was a predictor of PBV (r 5 0.92 and 0.02, respectively).Conclusions and Clinical Importance: Increased PBV, not decreased FSV, is the main cause of increased nPTT in MR. Increased nPTT can be used as an indicator of abnormal cardiopulmonary function in dogs with MR.

show abstract

Section: Discussionmentioning

confidence: 99%

Pulmonary Blood Volume in Mitral Regurgitation in Cavalier King Charles Spaniels

Eriksson

Hansson

Häggström

et al. 2010

Journal of Veterinary Internal Medicine

View full text Add to dashboard Cite

show abstract

“…This increase of pulmonary blood flow (PBF) in the dorsocaudal area against gravity is also seen in other standing quadrupeds like horses. 16 Studies of canine PBF under anesthesia and mechanical ventilation show a gravitational effect on PBF 17,18 as is the case of conscious human subjects 19 but this may not represent what happens in non-anesthetized dogs. Another factor that may play a role in the development of caudodorsal PE is the normal presence of pleural pressure gradients.…”

Section: Discussionmentioning

confidence: 99%

IF1, the endogenous regulator of the F1Fo-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy

Campanella

Seraphim

Abeti

et al. 2009

Biochimica et Biophysica Acta (BBA) - Bioenergetics

View full text Add to dashboard Cite

The protein IF1 limits mitochondrial ATP consumption when mitochondrial respiration is impaired by inhibiting the 'reverse' activity of the F(1)F(o)-ATPsynthase. We have found that IF1 also increases F(1)F(o)-ATPsynthase activity in respiring mitochondria, promoting its dimerization and increasing the density of mitochondrial cristae. We also noted that IF1 overexpression was associated with an increase in mitochondrial volume fraction that was conversely reduced when IF1 was knocked down using small interfering RNA (siRNA). The volume change did not correlate with the level of transcription factors involved in mitochondrial biogenesis. However, autophagy was dramatically increased in the IF1siRNA treated cells (-IF1), assessed by quantifying LC3-GFP translocation to autophagosomes, whilst levels of autophagy were low in IF1 overexpressing cells (+IF1). The increase in LC3-GFP labelled autophagosomes in -IF1 cells was prevented by the superoxide dismutase mimetic, manganese (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP). An increase in the basal rate of generation of reactive oxygen species (ROS) in -IF1 cells was demonstrated using the fluorescent probe dihydroethidium (DHE). Thus, IF1 appears to limit mitochondrial ROS generation, limiting autophagy which is increased by IF1 knockdown. Variations in IF1 expression level may therefore play a significant role in defining both resting rates of ROS generation and cellular mitochondrial content.

show abstract

Section: Discussionmentioning

confidence: 99%

Quantitative analysis of scintigraphic findings in tibial stress fractures in Thoroughbred racehorses

Valdés‐Martínez¹,

Seiler²,

Maï³

et al. 2008

ajvr

View full text Add to dashboard Cite

show abstract

Characterization of the Pulmonary Circulation According to Hemodynamic Changes by Computed Tomography

Cited by 6 publications

References 0 publications

Pulmonary Blood Volume in Mitral Regurgitation in Cavalier King Charles Spaniels

Pulmonary Blood Volume in Mitral Regurgitation in Cavalier King Charles Spaniels

IF1, the endogenous regulator of the F1Fo-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy

Quantitative analysis of scintigraphic findings in tibial stress fractures in Thoroughbred racehorses

Contact Info

Product

Resources

About