Characterization of the protective response against a homologous challenge infection with Strongyloides venezuelensis in rats

Baek, Byeong Kirl; Islam, M. Khyrul; Kim, B.S; Lim, Chae-Woong; Hur, Jin; Oluoch, A.; Kim, C.H; Kakoma, Ibulaimu

doi:10.1016/s0304-4017(03)00085-2

Cited by 23 publications

(19 citation statements)

References 17 publications

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“…Some morphometric differences such as total body length, maximum body width, length of oesophagus and tail length were found between parasitic females from both host species. This variability might be due to the differential immune response among host species, as has been demonstrated for other species of Strongyloides in hosts after experimental alteration of their immune system (Dawkins 1989, Baek et al 2003. The morphometry of larvae given by Little (1966) also agrees with those obtained from culture in the present study.…”

Section: Discussionsupporting

confidence: 80%

Strongyloides myopotami in ctenomyid rodents: Transition from semi-aquatic to subterranean life cycle

Rossin

Varela

Timi

2009

Acta Parasitologica

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Strongyloides myopotami, a parasite of Myocastor coypus (nutria or coypu), was found during an extensive parasitological survey carried out on parasitic helminths of 5 species of subterranean rodents (tuco-tucos) belonging to the genus Ctenomys from Argentina and Uruguay. Strongyloides myopotami became known by causing "marsh itch" (also called "nutria itch" or "swimmer's itch"), a severe rash caused by larvae that enter the skin in humans, and it is recognised as a zoonosis for people handling nutria fur. In the present study S. myopotami was found in 2 of the 5 examined species of Ctenomys (C. talarum from Argentina and C. pearsoni from Uruguay), both inhabiting the vicinity of water courses. Population descriptors of S. myopotami in C. talarum showed that a population of this parasite is well established in this rodent. The development of infective filariform larvae from eggs in the faeces of C. talarum and the prevalence of gravid parasitic females in this host can be considered as evidence of the establishment of a population of S. myopotami independent of the source population parasitizing M. coypus. Therefore, the presence of S. myopotami in these species of tuco-tucos indicates a change from a semi-aquatic to subterranean life cycle. Evidence that tuco-tucos are reservoirs for these nematodes and therefore may be a risk to human health in the areas studied is provided.

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Section: Discussionsupporting

confidence: 80%

Strongyloides myopotami in ctenomyid rodents: Transition from semi-aquatic to subterranean life cycle

Rossin

Varela

Timi

2009

Acta Parasitologica

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“…The mean prepatent period for S. venezuelensis among these primates was found to be similar to those observed using other animal models, thus demonstrating that this parameter alone seems to be barely affected by the type of host. The duration of the patent period in days was on average greater than previously seen for mice (Sato and Toma 1990;Amarante and OliveiraSequeira 2002;Martins et al 2009), hamsters (Shi et al 1994) and even rats (Wertheim 1970;Tamura 1993;Baek et al 2003)-the natural host.…”

Section: Discussionmentioning

confidence: 78%

Callithrix penicillata as a nonhuman primate model for strongyloidiasis

2012

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In order to better understand experimental strongyloidiasis in small New World primates, and to evaluate aspects of reinfection and immunosuppression induced by glucocorticoids, nine specimens of Callithrix penicillata (Primates: Cebidae) were administered (by subcutaneous injection, sc) 3000 infective larvae of a strain of Strongyloides venezuelensis (Rhabditida: Strongyloididae) that had been maintained in successive passages through AKR/J mice since 1987. The mean prepatent period was 5.6 ± 0.7 days post-infection (DPI). The mean patent period of infection among the untreated animals (marmosets 1-7) was 123.4 ± 61.4 DPI. Two animals (marmosets 8 and 9) received dexamethasone (2.5 mg/kg, sc) for five consecutive days starting on the 20th day after infection, but this treatment did not alter the course of the infection, and the patent period for these animals was 100.5 ± 58.7 DPI (59 and 142, respectively). Stool examination showed that the highest quantities of parasite eggs were expelled between the 8th and 19th days after inoculation of the larvae. Thereafter, there was a gradual reduction in the number of parasite eggs in feces of all marmosets. During the chronic phase of the infection, before completely negative parasitological findings were obtained, the parasitological examinations were intermittently positive. Reinfection of three of these animals did not result in new positive examinations. However, given the receptiveness of these animals to initial infection with S. venezuelensis and their similarities to human beings, it is proposed that C. penicillata could be used as a nonhuman primate model for experimental strongyloidiasis.

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“…a Fully mature 4-week-old adult worm recovered from a primarily infected rat. b Underdeveloped 4-week-old worm from a re-infected rat, the same magnification as a rats develop strong protective immunity against challenge infection by Strongyloides venezuelensis, as manifested by a marked reduction in worm population, stunted body length and width, damaged reproductive organs, impaired egg production, and a rapid expulsion of the worms (Baek et al 2003). Rats also show resistance to re-infection by the blood fluke Schistosoma mansoni (Cetre et al 1999;Khalife et al 2000).…”

Section: Discussionmentioning

confidence: 95%

Factors in the resistance of rats to re-infection and super-infection by Clonorchis sinensis

Hong-man

Chung

et al. 2008

Parasitol Res

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Rats develop resistance to re-infection by Clonorchis sinensis while humans do not. We investigated factors involved in the development of resistance to re-infection and super-infection in rats. Sprague-Dawley rats were infected by C. sinensis metacercariae and treated with praziquantel, then re-infected after immune modulation. The rats were also subjected to super-imposed infection after primary infection. Resistance to re-infection was observed by lowered rates of worm recovery after various durations from treatment; 1% at 5days and 24.4% at 11months vs 56.2% in the control. Similar significant resistance was observed in the super-infected rats after 3weeks of primary infection. The re-infected or super-infected worms grew very slowly and remained immature. Resistance disappeared in immune-suppressed and nude rats but not in splenectomized rats. Immunization with antigens of C. sinensis produced no resistance. Local tissue reaction and immune response in the infected bile duct may play an important role in the resistance, although the crowding effect may also be implicated in resistance in super-infected rats.

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Characterization of the protective response against a homologous challenge infection with Strongyloides venezuelensis in rats

Cited by 23 publications

References 17 publications

Strongyloides myopotami in ctenomyid rodents: Transition from semi-aquatic to subterranean life cycle

Strongyloides myopotami in ctenomyid rodents: Transition from semi-aquatic to subterranean life cycle

Callithrix penicillata as a nonhuman primate model for strongyloidiasis

Factors in the resistance of rats to re-infection and super-infection by Clonorchis sinensis

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