Characterization of the oleic acid/iron oxide nanoparticle interface by magnetic resonance

Masur, Sabrina; Zingsem, Benjamin; Marzi, T.; Meckenstock, R.; Farle, Michael

doi:10.1016/j.jmmm.2016.03.045

Cited by 32 publications

(14 citation statements)

References 13 publications

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“…is observed, what reveals that the oleic acid is adsorbed chemically on the SPION as a carboxylate. The peaks detected in the spectrum of the non-functionalized SPION in water are typically obtained in aqueous solutions [31,32].…”

Section: Spions Synthesis and Characterizationmentioning

confidence: 99%

Co-encapsulation of superparamagnetic nanoparticles and doxorubicin in PLGA nanocarriers: Development, characterization and in vitro antitumor efficacy in glioma cells

Luque-Michel

Sebastián

Larrea

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

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With a very poor prognosis and no clear etiology, glioma is the most aggressive cancer in the brain. Thanks to its versatility, nanomedicine is a promising option to overcome the limitations on chemotherapy imposed by the blood brain barrier (BBB). The objective of this paper was to obtain monitored tumor-targeted therapeutic nanoparticles (NPs). To that end, theranostic surfactant-coated polymer poly-Lactic-co-Glycolic Acid (PLGA) nanoplatform encapsulating doxorubicin hydrochloride (DOX) and superparamagnetic iron oxide NPs (SPIONs) were developed. Different non-ionic surfactants known as BBB crossing enhancers (Tween 80, Brij-35, Pluronic F68 or Vitamin E-TPGS) were used to develop 4 types of theranostic nanoplatforms, which were characterized in terms of size and morphology by DLS, TEM and STEM-HAADF analyses. Moreover, the 3-month stability test, the therapeutic efficacy against different glioma cell lines (U87-MG, 9L/LacZ and patient derived-neuronal stem cells) and the Magnetic Resonance Imaging (MRI) relaxivity were studied. Results showed that the synthesised nanoplatforms were stable at 4 ºC after their lyophilization, being that of paramount importance to ensure a long-term stability in a future in vivo application. Furthermore, the theranostic nanoplatforms were efficient in the in vitro treatment of glioma cells, proving to have imaging efficacy as MRI contrast agents. Our results show an efficient loading of drugs and good value of the relaxivity. Therefore, the efficient theranostic hybrid nanoplatform developed here could be used to perform MRI-guided delivery of hydrophobic drugs.

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Section: Spions Synthesis and Characterizationmentioning

confidence: 99%

Co-encapsulation of superparamagnetic nanoparticles and doxorubicin in PLGA nanocarriers: Development, characterization and in vitro antitumor efficacy in glioma cells

Luque-Michel

Sebastián

Larrea

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

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“…In functionalization or stabilization of materials, the interaction of the organism with the inorganic surface occurs through processes of physical absorption or chemical interactions between the ligand groups contained in the organic molecule and the surface atoms of the NPs. A case to be highlighted is the molecules that contain the ligand group carboxyl owing to the bidentate coordination capacity of the nanomaterials surface by the presence of the ligand groups –OH and =O, producing the efficient grafting of organic brushes and formation of the stabilizer housing [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Atmospheric Corrosion, Antibacterial Properties, and Toxicity of Silver Nanoparticles Synthesized by Two Different Routes

DeAlba-Montero

Ruiz-Torres

Portales-Pérez

et al. 2020

Bioinorganic Chemistry and Applications

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Silver nanoparticles (AgNPs) have been widely employed or incorporated into different materials in biological application, due to their antibacterial properties. Therefore, antimicrobial capacity and cytotoxicity have been highly studied. However, most of these reports do not consider the possible corrosion of the nanomaterials during their exposure to atmospheric conditions since AgNPs undergo a transformation when they come in contact with a particular environment. Derived from this, the functionality and properties of the nanoparticles could decrease noticeably. The most common silver corrosion process occurs by the interaction of AgNPs with sulfur species (H2S) present in the atmospheric air, forming a corrosion layer of silver sulfide around the AgNPs, thus inhibiting the release of the ions responsible for the antimicrobial activity. In this work, AgNPs were synthesized using two different methods: one of them was based on a plant extract (Brickellia cavanillesii), and the other one is the well-known method using sodium borohydride (NaBH4). Chemical stability, corrosion, antibacterial activity, and toxic activity were evaluated for both sets of prepared samples, before and after exposition to atmospheric air for three months. The structural characterization of the samples, in terms of crystallinity, chemical composition, and morphology, evidenced the formation of link structures with nanobridges of Ag2S for non- “green” AgNPs after the air exposition and the intact preservation of silver core for the “green” sample. The antibacterial activity showed a clear improvement in the antimicrobial properties of silver in relation to the “green” functionalization, particle size control, and size reduction, as well as the preservation of the properties after air exposition by the effective “green” protection. The cytotoxicity effect of the different AgNPs against mononuclear cells showed a notable increment in the cell viability by the “green” functionalization.

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“…7 Wang et al 8 produced Fe3O4 nanoparticles that stable in organic solvents by using DMSO to oxidize Fe 2+ and oleic acid as surfactant. Masur et al 9 produced monodisperse magnetite nanoparticles by using thermal decomposition method and study their magnetic properties by using electron spin resonances (ESR). Electron spin resonance (ESR) is a very sensitive technique for examining unpaired electron species such as superparamagnetic Fe3O4 nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…∆ values of 200-320 cm -1 were attributed to monodentate, whereas bridging bidentate and chelating bidentate interaction were represented by ∆ values of140-190 cm -1 and <110 cm -1 , respectively. 7,9 Therefore, the existence ∆ of 145 was due to the bridging bidentate interaction, where a covalent bond could be attributed to the COOgroup and Fe interaction. The coating-replacing group process at the nano-magnetite surface was briefly described on Figure-3.…”

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confidence: 99%

SYNTHESIS AND CHARACTERIZATION OF MAGNETIC Fe3O4 NANOPARTICLES USING OLEIC ACID AS STABILIZING AGENT

Nalle¹,

Wahid²,

Wulandari³

et al. 2019

RJC

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Magnetic iron oxide nanoparticles (Fe3O4) provide multiple advantages for drug delivery application due to their inertness, non-toxicity, biocompatibility, and ease of detection as the diagnostic tool for contrast imaging in the human body. To protect against oxidation, preferably covalently bonded a surfactant for coating Fe3O4 is required. For this purpose, in the present study, oleic acid (OA) was applied to stabilize Fe3O4 magnetic nanoparticles via onepot-three-component reaction. Mild conditions as a well as simple reaction could be attributed to this method in producing Fe3O4-OA nanoparticles. The amount of oleic acid (OA) was studied to explore properties of the resulted nanoparticles. Infrared spectroscopy revealed that OA is chemisorbed via a carboxyl group onto the surface of the iron oxide nanoparticle and is coordinated symmetrically to the oxide atoms. Furthermore, there is a ligand exchange between -OH groups and -COO groups on the Fe3O4 nanoparticle surfaces. X-ray diffraction (XRD) spectra indicated that Fe3O4 phase was predominantly obtained beside small amount of γ-Fe2O3 phase. The average crystallite size of the synthesized Fe3O4 nanoparticles at different amount of OA was found in the range of 6.60 nm to 9.48 nm. Magnetic properties of the nanoparticles were determined by electron spin resonance (ESR). The gradient curve of ESR spectra revealed that Fe3O4 and OA-coated Fe3O4 nanoparticles possess significantly different magnetic properties.

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Characterization of the oleic acid/iron oxide nanoparticle interface by magnetic resonance

Cited by 32 publications

References 13 publications

Co-encapsulation of superparamagnetic nanoparticles and doxorubicin in PLGA nanocarriers: Development, characterization and in vitro antitumor efficacy in glioma cells

Co-encapsulation of superparamagnetic nanoparticles and doxorubicin in PLGA nanocarriers: Development, characterization and in vitro antitumor efficacy in glioma cells

Atmospheric Corrosion, Antibacterial Properties, and Toxicity of Silver Nanoparticles Synthesized by Two Different Routes

SYNTHESIS AND CHARACTERIZATION OF MAGNETIC Fe3O4 NANOPARTICLES USING OLEIC ACID AS STABILIZING AGENT

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