Characterization of the novel chemically modified fungal polysaccharides as the macrophage stimulators

Dergunova, M. A.; Alexeenko, T. V.; Zhanaeva, S. Ya.; Filyushina, E. E.; Бузуева, И. И.; Колесникова, О. П.; Kogan, Grigorij; Короленко, Т. А.

doi:10.1016/j.intimp.2009.02.009

Cited by 18 publications

(10 citation statements)

References 46 publications

(45 reference statements)

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“…Furthermore, TNF-␣ has been reported to exert in anti influenza effect, which is greater than that of interferon-␥ and interferon-␣ [48]. Previous studies found that polysaccharides caused significant increase of the production of TNF-␣ [49,50]. The present results showed that SSP1 significantly enhanced the level of TNF-␣ in serum of mice.…”

Section: Discussionsupporting

confidence: 56%

Immunomodulatory effect of a Sophora subprosrate polysaccharide in mice

Shuai

Liu

et al. 2010

International Journal of Biological Macromolecules

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Section: Discussionsupporting

confidence: 56%

Immunomodulatory effect of a Sophora subprosrate polysaccharide in mice

Shuai

Liu

et al. 2010

International Journal of Biological Macromolecules

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“…Carboxymethylated b-(1,3)-D-glucan (CMG, Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia) was administered twice at a dose of 25 mg•kg -1 , i.p., 72 and 24 h before P-407. As was shown earlier, CMG at this dose induced macrophage stimulation both in rats and mice (Dergunova et al 2009). Control mice received CMG at the same dose and frequency of administration.…”

Section: Methodssupporting

confidence: 80%

Influence of atorvastatin and carboxymethylated glucan on the serum lipoprotein profile and MMP activity of mice with lipemia induced by poloxamer 407

Короленко¹,

Тузиков

Черканова³

et al. 2012

Can. J. Physiol. Pharmacol.

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The effects of atorvastatin and carboxymethylated β-glucan (CMG) on the lipoprotein-cholesterol (LP-C) and lipoprotein-triglyceride (LP-TG) fractions and subfractions at the early stage of murine hyperlipidemia, and its pleiotropic anti-inflammatory effects, were studied. Atorvastatin and CMG were administered in ICR male mice with acute lipemia induced with a single injection of poloxamer 407 (P-407). A novel small-angle X-ray scattering method for the determination of fractional and subfractional composition of LP-C and LP-TG was used. In P-407-treated animals, there was a drastic increase of total cholesterol and especially TG. Atorvastatin decreased both the total cholesterol and TG, but not to control levels. CMG primarily decreased TG and was not as potent as atorvastatin. P-407 increased atherogenic LDL-C (IDL-C and LDL(1-3)-C subfractions) and very low-density lipoprotein-C (VLDL-C) (VLDL(1-2)-C and VLDL(3-5)-C subfractions) fractions, with an increase of the total anti-atherogenic HDL-C fraction (HDL(2)-C subfraction). Atorvastatin treatment of lipemia was followed by a decrease in the total LP-C, total LDL-C (LDL(1-3)-C subfraction), and the LDL(1-3)-TG subfraction. Additionally, atorvastatin treatment resulted in an increase in the serum matrix metalloproteases activity both in control and P-407-treated mice. In general, high-dose atorvastatin therapy exerts its lipid-lowering and pleiotropic effects in the early stages of acute lipemia induced in mice by treatment with P-407.

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“…The activity of acid phosphatase in macrophages increases with the activation of macrophages and decreases with the inhibition of macrophages. Therefore, the immune function of macrophages can be represented by the activity of acid phosphatase [14,20]. In the present study, the stimulating indices of crude HCPS and its purified fractions of HCPS-1, HCPS-2 and HCPS-3 on acid phosphatase activity in peritoneal macrophages were all above 1.0 (Fig.…”

Section: Effect Of Hcps On Acid Phosphatase Activity In Peritoneal Masupporting

confidence: 58%