Characterization of the nonlinear elastic behavior of chinchilla tympanic membrane using micro-fringe projection

Abstract

The mechanical properties of an intact, full tympanic membrane (TM) inside the bulla of a fresh chinchilla were measured under quasi-static pressure from −1.0 kPa to 1.0 kPa applied on the TM lateral side. Images of the fringes projected onto the TM were acquired by a digital camera connected to a surgical microscope and analyzed using a phase-shift method to reconstruct the surface topography. The relationship between the applied pressure and the resulting volume displacement was determined and analyzed using a finite element model implementing a hyperelastic 2nd-order Ogden model. Through an inverse method, the best-fit model parameters for the TM were determined to allow the simulation results to agree with the experimental data. The nonlinear stress-strain relationship for the TM of a chinchilla was determined up to an equibiaxial tensile strain of 31% experienced by the TM in the experiments. The average Young’s modulus of the chinchilla TM from ten bullas was determined as approximately 19 MPa.

Finite element simulation for the effect of loading rate on visco‐hyperelastic characterisation of soft materials by spherical nanoindentation

“…In recent years of research, the focus primarily moved to the characterisation of biomaterials including tympanic membrane, brain tissue, cornea etc. [3][4][5]. Cells are the basic element of these biomaterials, their mechanical properties change with the internal functional state or external environmental stimuli.…”

Tonometer validation and intraocular pressure reference values in the normal chinchilla (Chinchilla lanigera)

“…It is thought the domestic chinchilla originated from the Chinchilla lanigera . The chinchilla is used as a model for laboratory research and is an increasingly popular companion animal.…”

Assessment methodology for pressure-related aural discomfort in high-speed trains using airtightness experiments and mathematical models

“…Furthermore, the key to accomplishing the prediction and evaluation of aural sensation depends on establishing appropriate indicators, which can be used to represent the vibration characteristics of the middle ear. In previous studies, the displacement, volume displacement, 14 displacement transfer function, and velocity 15,16 were observed to interpret the sound transfer functions of the middle ear. Compared with other structures of the human middle ear, tympanic membrane (TM) is more sensitive to pressure changes and susceptible to trauma because it is directly exposed to the atmospheric environment and acts as the first receptor of the pressure wave.…”