Abstract:Cell-based therapies are promising treatment strategies for a variety of disorders ranging from cancer to spinal cord injuries. However, there is a risk of the transplanted cells becoming malignant. As a safeguard against this, suicide gene systems can be implemented so that transplanted cells can be eliminated if necessary by administering a pro-drug. Herpes simplex virus thymidine kinase (HSV-tk) paired with the pro-drug ganciclovir (GCV) is one of the most studied suicide gene systems. However, it can only … Show more
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