Characterization of the neuraminidase genes from human influenza A viruses circulating in Iran from 2010 to 2015

Moasser, Elham; Behzadian, Farida; Moattari, Afagh; Fotouhi, Fatemeh; Zaraket, Hassan

doi:10.1007/s00705-017-3603-y

Cited by 4 publications

(7 citation statements)

References 40 publications

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“…It has also been reported that mutation N248D may be related to oseltamivir resistance because N248 is located near the binding pocket (Figure ). This N44S mutation may change the antigenic properties of influenza viruses because of an increase in the number of glycosylation sites . The N200S mutation possessed by genetic group 6 may be related to immune evasion by the virus because the mutation is at the antibody recognition site .…”

Section: Discussionmentioning

confidence: 99%

“…This N44S mutation may change the antigenic properties of influenza viruses because of an increase in the number of glycosylation sites. 33 The N200S mutation possessed by genetic group 6 may be related to immune evasion by the virus because the mutation is at the antibody recognition site. 34 The V264I and N270K mutations detected in subgroup 6B are located in the antigenic region of the NA, and these two mutations may change the antigenic properties as well.…”

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confidence: 99%

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Genetic and antigenic characterization of influenza A(H1N1)pdm09 in Yantai, China, during the 2009–2017 influenza season

Liu

Gong

et al. 2018

Journal of Medical Virology

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Objective This study was performed to determine the antigenic and genetic characteristics and evaluate potential vaccine efficacy of influenza A (H1N1)pdm09 in Yantai from August 2009 to August 2017. Materials and Methods A total of 10 236 swabs were collected among patients with an influenza‐like illness who were admitted to two sentinel surveillance hospitals in Yantai, East China, from August 2009 to August 2017. All specimens were cultured in Madin‐Darby canine kidney cells and identified by haemagglutination‐inhibition assay. Complete sequences of haemagglutinin (HA) and neuraminidase of 51 influenza A(H1N1)pdm09 strains circulating in Yantai were amplified, sequenced and analysed using molecular and phylogenetic methods. The potential vaccine efficacy was calculated using the p epitope model which measured the antigenic variation based on the changes in the dominant epitope of HA. Results The results showed that most Yantai strains were grouped into genetic clades 1.7, 6C, 6B.1 and 6B.2. The amino acid substitutions accumulated gradually in HA proteins and considerable genetic variation were observed in circulating A(H1N1)pdm09 viruses during the seven influenza seasons. The V241I, N369K, N386K and K432E mutations which may change the binding pattern and affinity of oseltamivir for neuraminidase were detected in the strains circulating in 2016/2017 and 2017/2018 seasons and the recommended vaccine strains could afford optimal protection against the influenza A/H1N1pdm09. Conclusions Although influenza A(H1N1)pdm09 viruses acquired significant genetic variation over the course of seven influenza seasons, the recommended vaccine strains still afforded protection against main circulating strains. Continuous epidemiological and virological surveillance are necessary.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Genetic and antigenic characterization of influenza A(H1N1)pdm09 in Yantai, China, during the 2009–2017 influenza season

Liu

Gong

et al. 2018

Journal of Medical Virology

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“…19 Moasser et al also showed that most cases occurred in February and March. 20 Gouya et al reported that influenza is on the rise in the second half of the year coinciding with the reopening of schools and universities. 21 Belderok et al showed that traveling has an effect on the epidemiology of influenza.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Influenza in Fars Province, Southern Iran; a Population-Based Study (2015–2019)

et al. 2021

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Background: Influenza is one of the most important viral diseases with high mortality and morbidity that can have a great impact on public health and economy. Objective: To investigate the clinical and epidemiological features of influenza virus A/H1N1, A/H3N2, and B infection in Fars province, southern Iran, in 2015-2019. Methods: In this retrospective cross-sectional study, we assessed the archived data of

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“…Many viruses, such as the influenza virus, evolve faster than normal transmission, and phylogenetic techniques as an ideal and objective tool can be used for reconstructing spatio‐temporal dynamics and transmission history 6 . With respect to implementation of this method for viruses like influenza, there are a series of studies which had been conducted in Iran to analyze the genetic diversity and drug susceptibility of the NA gene expressed by influenza A/H1N1pdm09 and A/H3N2 viruses on national and subnational level, and also comparing HA and NA genes of three 2009 pandemic influenza A/H1N1 isolates with the vaccine strain and some strains from different countries 7–9 . In some other studies bioinformatics methods were used to define the prevalence library and to study the trend of changes in HA and NA sequences of type A H1N1 influenza viruses from 2006 to 2013 10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…6 With respect to implementation of this method for viruses like influenza, there are a series of studies which had been conducted in Iran to analyze the genetic diversity and drug susceptibility of the NA gene expressed by influenza A/H1N1pdm09 and A/H3N2 viruses on national and subnational level, and also comparing HA and NA genes of three 2009 pandemic influenza A/H1N1 isolates with the vaccine strain and some strains from different countries. [7][8][9] In some other studies bioinformatics methods were used to define the prevalence library and to study the trend of changes in HA and NA sequences of type A H1N1 influenza viruses from 2006 to 2013. 10,11 Further phylogenetic analysis on the NS gene of A/H1N1 isolates revealed that all Iranian isolates, except the A/Tehran/SMO08/2015, were close to strains from continental countries of Asia and North America, with 99% identity.…”

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confidence: 99%

Reconstruction of molecular evolution of human influenza A H1N1/2009 virus in Iran and neighboring countries

Ghalekhani

Bokaie

Eybpoosh

et al. 2022

Journal of Medical Virology

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In this study, the time and path of transmission of H1N1 serotype influenza A viruses in Iran and neighboring countries have been investigated by using Bayesian phylogeography analysis on the sequences extracted from the gene bank. We obtained all hemagglutinin (HA) and neuraminidase (NA) nucleotide sequences of influenza H1N1 available up to December 25, 2020, from Iran and its neighboring countries (i.e., Pakistan, Afghanistan, Turkmenistan, Armenia, Azerbaijan, Turkey, and Iraq). We also performed a Bayesian Markov chain Monte Carlo method to infer the evolutionary dynamic and the most recent common ancestor for the HA and NA sequences. Based on the extracted sequences, the age of emergence of H1N1 influenza virus serotype was older in Iran compared to neighboring countries, and with some degree of uncertainty, it seems Tehran had a key role and epicenter of transmission to other cities within Iran. The mean time of the most recent common ancestor of H1N1 viruses was 1989 (95% HPD: 1980–1994) for HA and NA as well. Along with ordinary measures like resource management, diagnostic approaches, and preparedness to fight against viruses that were in place, continuous monitoring, and screening of H1N1 serotype influenza virus in the country, especially by implementation of feasible, effective, and innovative measures at borderline should be initiated and identified gaps and shortage that should be a priority for virus control. It is also important for countries to have a regional monitoring program in addition to internal monitoring programs, as well as to start a virus molecular care program.

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Characterization of the neuraminidase genes from human influenza A viruses circulating in Iran from 2010 to 2015

Abstract: The ongoing evolution of influenza viruses and the detect of influenza viruses with reduced susceptibility to NAIs warrants continuous monitoring of the circulating strains.

Cited by 4 publications

References 40 publications

Genetic and antigenic characterization of influenza A(H1N1)pdm09 in Yantai, China, during the 2009–2017 influenza season

Genetic and antigenic characterization of influenza A(H1N1)pdm09 in Yantai, China, during the 2009–2017 influenza season

Epidemiology of Influenza in Fars Province, Southern Iran; a Population-Based Study (2015–2019)

Reconstruction of molecular evolution of human influenza A H1N1/2009 virus in Iran and neighboring countries

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