Characterization of the Network Structure of Carbodiimide Cross-Linked Gelatin Gels

Kuijpers, A.J.; Engbers, G.H.M.; Feijén, Jan; Smedt, Stefaan C. De; Meyvis, Tom; Demeester, Joseph; Krijgsveld, Jeroen; Zaat, Sebastian A. J.; Dankert, J.

doi:10.1021/ma981929v

Cited by 257 publications

(194 citation statements)

References 28 publications

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“…The upper plate was then lowered until it reached the hydrogel surface. Gap-setting optimizations were undertaken according to a procedure described elsewhere [31]. When GG or SCLG were tested, an appropriate amount of the samples was spread onto the plate geometry to obtain a sample of the appropriate height.…”

Section: Rheological Characterizationmentioning

confidence: 99%

Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations

Coviello¹,

Matricardi²,

Alhaique³

et al. 2013

Express Polym. Lett.

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Abstract. Guar gum (GG) and Guar gum/borax (GGb) hydrogels are studied by means of rheology, Low Field Nuclear Magnetic Resonance (LF NMR) and model drug release tests. These three approaches are used to estimate the mesh size (!) of the polymeric network. A comparison with similar Scleroglucan systems is carried out. In the case of GGb, the rheological and Low Field NMR estimations of ! lead to comparable results, while the drug release approach seems to underestimate !. Such discrepancy is attributed to the viscous effect of some polymeric chains that, although bound to the network to one end, can freely fluctuate among meshes. The viscous drag exerted by these chains slows down drug diffusion through the polymeric network. A proof for this hypothesis is given by the case of Scleroglucan gel, where the viscous contribution is not so significant and a good agreement between the rheological and release test approaches was found. Vol.7, No.9 (2013) 733-746 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2013.71 * Corresponding author, e-mail: mariog@dicamp.univ.trieste.it © BME-PT mation in aqueous solution and a single coiled disordered conformation in methylsulphoxide or at high pH values (NaOH$>0.2 M) [10,11]. Due to its peculiar properties, SCLG was extensively used for various commercial applications (secondary oil recovery, ceramic glazes, food, paints, cosmetics, etc.) [12] and it was also investigated for modified/ sustained release formulations and ophthalmic preparations [13]. Actually, it is well known that borax is an efficient crosslinker for polymers bearing hydroxyl groups but the type of formed linkages is still debated and so far two main models have been proposed. The most popular one implies the existence of pure chemical crosslinks between the polymeric chains and borax [14], and it was proposed for the GG/ borax interactions. According to the other model, the borax ions hold together the polymeric chains by means of mixed physical/chemical linkages. This model was firstly proposed for poly-(vinylalcohol) [15] and it was recently suggested also for SCLG [16,17]. The considerable effort devoted to the study of polymer-ion complexes is due to the wide range of application of these systems. In particular, the complex between GG and borate was previously studied by several authors [18,19] that investigated the effect of polymer and borate concentration, temperature, environmental pH conditions, and GG molecular weight on the peculiar rheological properties detected by the frequency dependence of relaxation spectra. Furthermore, a detailed study of the crosslinking reaction of borate ion with polyhydroxy polymers was carried out by means of 11 Keywords: polymer gels, rheology, low field NMR, transport processes, mesh-size eXPRESS Polymer Letters

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Section: Rheological Characterizationmentioning

confidence: 99%

Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations

Coviello¹,

Matricardi²,

Alhaique³

et al. 2013

Express Polym. Lett.

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“…Gelatin resorcinol and cyanoacrylates in particular have favorable mechanical properties, but both are known to have cytotoxic effects due to the breakdown of cyanoacrylates into formaldehyde and the use of formaldehyde as a curing agent in the gelatin-resorcinol system [3,4]. Several labs have reported on efforts to lower cytotoxicity of these systems [5][6][7]. The fibrin glues, on the other hand, are generally considered highly biocompatible and adhesive to tissue surfaces but have very low cohesive strength [8,9].…”

Section: Introductionmentioning

confidence: 99%

Thermal gelation and tissue adhesion of biomimetic hydrogels

et al. 2007

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Marine and freshwater mussels are notorious foulers of natural and manmade surfaces, secreting specialized protein adhesives for rapid and durable attachment to wet substrates. Given the strong and water-resistant nature of mussel adhesive proteins, significant potential exists for mimicking their adhesive characteristics in bioinspired synthetic polymer materials. An important component of these proteins is L-3,4-dihydroxylphenylalanine (DOPA), an amino acid believed to contribute to mussel glue solidification through oxidation and crosslinking reactions. Synthetic polymers containing DOPA residues have previously been shown to crosslink into hydrogels upon the introduction of oxidizing reagents. Here we introduce a strategy for stimuli responsive gel formation of mussel adhesive protein mimetic polymers. Lipid vesicles with a bilayer melting transition of 37°Cwere designed from a mixture of dipalmitoyl and dimyristoyl phosphatidylcholines and exploited for the release of a sequestered oxidizing reagent upon heating from ambient to physiologic temperature. Colorimetric studies indicated that sodium-periodate-loaded liposomes released their cargo at the phase transition temperature, and when used in conjunction with a DOPA-functionalized poly(ethylene glycol) polymer gave rise to rapid solidification of a crosslinked polymer hydrogel. The tissue adhesive properties of this biomimetic system were determined by in situ thermal gelation of liposome/polymer hydrogel between two porcine dermal tissue surfaces. Bond strength measurements showed that the bond formed by the adhesive hydrogel (mean = 35.1 kPa, SD = 12.5 kPa, n = 11) was several times stronger than a fibrin glue control tested under the same conditions. The results suggest a possible use of this biomimetic strategy for repair of soft tissues.

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“…Some natural polymers including proteins [213], polysaccharides [214,215] or hybrids of protein and polysaccharides [216][217][218] have been found to demonstrate thermo-responsive behavior. Among them, cellulose derivatives, such as methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC), have shown thermo-responsive behavior with phase transition temperatures between 40 °C and 50 °C for MC and between 75 °C and 90 °C for HPMC [219].…”

Section: Temperature-sensitive or Thermo-responsive Gelsmentioning

confidence: 99%

Smart polymeric gels: Redefining the limits of biomedical devices

Chaterji

Kwon

Park

2007

Progress in Polymer Science

552

364

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This review describes recent progresses in the development and applications of smart polymeric gels, especially in the context of biomedical devices. The review has been organized into three separate sections: defining the basis of smart properties in polymeric gels; describing representative stimuli to which these gels respond; and illustrating a sample application area, namely, microfluidics. One of the major limitations in the use of hydrogels in stimuli-responsive applications is the diffusion rate limited transduction of signals. This can be obviated by engineering interconnected pores in the polymer structure to form capillary networks in the matrix and by downscaling the size of hydrogels to significantly decrease diffusion paths. Reducing the lag time in the induction of smart responses can be highly useful in biomedical devices, such as sensors and actuators. This review also describes molecular imprinting techniques to fabricate hydrogels for specific molecular recognition of target analytes. Additionally, it describes the significant advances in bottom-up nanofabrication strategies, involving supramolecular chemistry. Learning to assemble supramolecular structures from nature has led to the rapid prototyping of functional supramolecular devices. In essence, the barriers in the current performance potential of biomedical devices can be lowered or removed by the rapid convergence of interdisciplinary technologies.

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Characterization of the Network Structure of Carbodiimide Cross-Linked Gelatin Gels

Cited by 257 publications

References 28 publications

Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations

Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations

Thermal gelation and tissue adhesion of biomimetic hydrogels

Smart polymeric gels: Redefining the limits of biomedical devices

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