2000
DOI: 10.1590/s0100-879x2000000200002
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Abstract: The present paper describes important features of the immune response induced by the Cry1Ac protein from Bacillus thuringiensis in mice. The kinetics of induction of serum and mucosal antibodies showed an immediate production of anti-Cry1Ac IgM and IgG antibodies in serum after the first immunization with the protoxin by either the intraperitoneal or intragastric route. The antibody fraction in serum and intestinal fluids consisted mainly of IgG1. In addition, plasma cells producing anti-Cry1Ac IgG antibodies … Show more

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Cited by 42 publications
(29 citation statements)
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“…After intraperitoneal or intragastric administration of Cry1Ac to mice at relatively high dosage, IgG, IgM and mucosal IgA response were induced, but no IgE response was observed (Vazquez-Padron et al, 1999a;2000). This demonstrates that Cry1Ac has no or low allergenic potential.…”
Section: Assessment Of Allergenicity Of the Newly Expressed Proteinsmentioning
confidence: 88%
“…After intraperitoneal or intragastric administration of Cry1Ac to mice at relatively high dosage, IgG, IgM and mucosal IgA response were induced, but no IgE response was observed (Vazquez-Padron et al, 1999a;2000). This demonstrates that Cry1Ac has no or low allergenic potential.…”
Section: Assessment Of Allergenicity Of the Newly Expressed Proteinsmentioning
confidence: 88%
“…and i.n. administration of Cry3A to mice at relatively high dosage, IgG, IgM and mucosal IgA response were induced, but no IgE response was reported (Guerrero et al, 2004;Vazquez-Padron et al, 1999;2000). This demonstrates that Cry1Ac and Cry3A have no allergenic potential under the conditions used.…”
Section: Assessment Of Allergenicity Of the Newly Expressed Proteinsmentioning
confidence: 89%
“…This reduction could be a result of a proinflammatory process in the uterine mucosa produced by Bt in the dosage of 20.0 mg/100 g. According to Moreno-Fierros et al, (2000), Bt Cry 1Ac protein toxins can cause systemic immune responses in various locations, such as the reproductive system, after intraperitoneal and intravaginal application of 100 µg. It has also been reported that this toxin (Cry1Ac) is a specific potent inducer of immune responses in the uterine mucosal (Vázquez-Padrón et al, 2000).…”
Section: G IVmentioning
confidence: 99%