Characterization of the Mouse Rh Blood Group Gene

Westhoff, Connie M.; Schultze, A. B.; From, April; Wylie, Dwane E.; Silberstein, Leslie E.

doi:10.1006/geno.1999.5783

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…Homologs of the human Rh proteins are present in the RBCs of nonhuman primates 4 and rodents, 5 but most are not detected with human typing sera. This is due to the variation in amino acid residues located in the extracellular loops of the Rh protein 5 and probably also to conformational changes induced by transmembrane or cytoplasmic amino acid differences, as has been shown for some human Rh antigen variants 6 …”

mentioning

confidence: 99%

Evidence supporting the requirement for two proline residues for expression of c

Westhoff

Silberstein²,

Wylie³

2000

Transfusion

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Sequencing of Rh transcripts from the capuchin monkey supports the hypothesis that the expression of c requires two adjacent proline residues. Proline causes bends or loops in proteins, which, in this case, might form a unique, stable structure resistant to perturbations induced by changes in upstream or downstream residues. This would explain the scarcity in humans of c variants as compared to the other major Rh antigen variants, and the preservation of c reactivity despite 24-percent divergence between the human and capuchin Rh proteins.

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confidence: 99%

Evidence supporting the requirement for two proline residues for expression of c

Westhoff

Silberstein²,

Wylie³

2000

Transfusion

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“…RH and RHAG have been investigated in nonhuman primates 64,65 and rodents, [66][67][68] and most, with the exception of gorillas and chimpanzees, have a RHAG and only one RH gene. RH and RHAG have been investigated in nonhuman primates 64,65 and rodents, [66][67][68] and most, with the exception of gorillas and chimpanzees, have a RHAG and only one RH gene.…”

Section: Evolutionmentioning

confidence: 99%