Characterization of the metabolic actions of crude versus dispersed oil in salmon smolts via NMR-based metabolomics

Lin, Ching‐Yu; Anderson, Brian S.; Phillips, Bryn M.; Peng, A. C.; Clark, S.; Voorhees, Jennifer P.; Wu, Hung‐Ming; Martin, Michael; McCall, James; Todd, Charles R.; Hsieh, Fushing; Crane, D.; Viant, Mark R.; Sowby, Michael L.; Tjeerdema, Ronald S.

doi:10.1016/j.aquatox.2009.09.006

Cited by 46 publications

(28 citation statements)

References 28 publications

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“…In our results, no TPH were detected for each % of stock solution tested. These results are in accordance with other studies using different experimental approaches [8,10,[25][26][27]. It can therefore, be concluded that our experimental system is suitable for assessing the toxicity of dispersant application.…”

Section: Measurement Of the Droplet Size Of Dispersed Oilsupporting

confidence: 81%

“…For this reason, in an emergency context such an oil spill, it is necessary to have as soon as possible toxicity data to evaluate the potential biological impact. Many studies have evaluated the acute toxicity of dispersant alone [3][4][5][6] or dispersant enhanced water accommodated fractions [7][8][9][10]. These methods presented a major disadvantage.…”

Section: Introductionmentioning

confidence: 99%

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An Experimental System to Assess Potential Biological Impact of Operational Response During an Oil Spill

Dussauze¹,

Pichavant-Rafini²,

Théron³

et al. 2016

J Pet Environ Biotechnol

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In order to evaluate the potential toxicity of dispersant application in an oil slick in near-shore areas, this study presents an experimental system designed to perform toxicity tests on fish. Three possible oil spill scenario issues during an oil spill were tested on juvenile sea bass (Dicentrarchus labrax); the Water Soluble Fraction of oil; the Mechanical Dispersion of oil; the Chemical Dispersion of oil. Preliminary toxicity assays suggest that the experimental system is appropriate to assess the three experimental conditions during a period of 24 hours. This experimental system allowed obtaining "quick" and relevant results of acute toxicity in an emergency context such an oil spill.

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Section: Measurement Of the Droplet Size Of Dispersed Oilsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

An Experimental System to Assess Potential Biological Impact of Operational Response During an Oil Spill

Dussauze¹,

Pichavant-Rafini²,

Théron³

et al. 2016

J Pet Environ Biotechnol

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“…The increased amounts of amino acids were thought to have been contributed by either Sertoli cell or germ cells. Increases in amino acids have been reported in earthworms and salmon smolts exposed to PAHs (Jones et al, 2008;Lin et al, 2009a). After Vit E cotreatment, the changes in these testicular amino acids were potentially attenuated, indicating the anti-oxidative protective effects of Vit E. This protective mechanism ensures testicular function and the ability to adapt to additional stresses.…”

Section: Discussionmentioning

confidence: 91%

“…Therefore, an overview of the metabolic status that reflects an organism's phenotype can be described. The metabolomic approach has been widely applied in the fields of clinical pharmacology and toxicology, as well as environmental toxicology (Lin et al, 2009a;Santos et al, 2009). Understanding the impact of xenobiotics or environmental stress on the metabolome will help researchers understand the mechanisms underlying toxicity and will assist in further biomarker development.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Analysis of the Effects of Motorcycle Exhaust on Rat Testes and Liver

Lin

Liang

et al. 2014

Aerosol Air Qual. Res.

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Motorcycles are one of the primary means of transportation in many Asian metropolitan areas. Exposure to motorcycle exhaust (ME) has been shown to cause male reproductive toxicity in a rat inhalation model. In the present study, the molecular mechanisms underlying ME-induced male reproductive toxicity were examined in a rat model using nuclear magnetic resonance (NMR)-based metabolomics. Rats were treated with 1:10-diluted ME for 1 hour in the morning and 1 hour in the afternoon, daily, via head-nose-only exposure chambers, for a period of four weeks. Half of the ME-exposed rats were co-treated with vitamin E to examine its protective effects. Both hydrophilic and hydrophobic metabolites from the testes and liver were extracted for 1 H and J-resolved NMR analyses. The obtained NMR spectra were converted into series of spectral binned areas and subjected to orthogonal projections to latent structure-discriminant analyses. Decreased spermatid counts and elevated levels of betaine in the testes of rats in the ME-treated group were partially attenuated by vitamin E co-treatment. Although it was not statistically significant, we observed a consistent trend of partial reversal of the elevated levels of alanine, glycine, leucine, tyrosine, and valine in the testes of rats in the ME-treated group due to vitamin E co-treatment. Decreases in testicular ethanolamine and inositol were only significant in the group co-treated with ME and vitamin E. The testicular toxicity of ME may be due to alterations in lipid-and energy-related metabolism. We conclude that ME generates greater metabolic responses in the testes than in the liver. Treatment with vitamin E can partially reverse the molecular events in the testes.

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“…Functional genomics approaches have studied the transcriptional changes in the liver and other tissues of salmonids (Miller et al, 2009;Martin et al, 2010;Evans et al, 2011). There has also been some recent attention to exploration of salmonid physiology through the systematic measurement of small-molecule biochemical intermediates (metabolites) in the field known as "metabolomics" (Solanky et al, 2005;Viant et al, 2006;Viant, 2007;Lin et al, 2009;Hines et al, 2010). The majority of the focus in such studies has been on the toxicological and environmental impacts on the fish, including petrochemicals (Lin et al, 2009) and pesticides (Viant et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Differential metabolite levels in response to spawning-induced inappetence in Atlantic salmon Salmo salar

Cipriano¹,

Smith

Vermeersch

et al. 2015

Comparative Biochemistry and Physiology Part D: Genomics and Pr

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Characterization of the metabolic actions of crude versus dispersed oil in salmon smolts via NMR-based metabolomics

Cited by 46 publications

References 28 publications

An Experimental System to Assess Potential Biological Impact of Operational Response During an Oil Spill

An Experimental System to Assess Potential Biological Impact of Operational Response During an Oil Spill

Metabolomic Analysis of the Effects of Motorcycle Exhaust on Rat Testes and Liver

Differential metabolite levels in response to spawning-induced inappetence in Atlantic salmon Salmo salar

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