Characterization of the Membrane-Associated Electron-Bifurcating Flavoenzyme EtfABCX from the Hyperthermophilic Bacterium Thermotoga maritima
Xiaoxuan Ge,
Gerrit J. Schut,
Jessica Tran
et al.
Abstract:Electron bifurcation
is an energy-conservation mechanism in which
a single enzyme couples an exergonic reaction with an endergonic one.
Heterotetrameric EtfABCX drives the reduction of low-potential ferredoxin
(
E
°′ ∼ −450 mV) by oxidation
of the midpotential NADH (
E
°′ = −320
mV) by simultaneously coupling the reaction to reduction of the high-potential
menaquinone (
E
°′ = −74 mV). Electron
bifurcation occurs at the NADH-oxidizing bifurca… Show more
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