Characterization of the innate and adaptive immunity to Salmonella enteritidis PT1 infection in four broiler lines

Kramer, Judith M.; Visscher, A.H.; Wagenaar, J.A.; Boonstra-Blom, A.G.; Jeurissen, S.H.M.

doi:10.1016/s0165-2427(01)00261-6

Cited by 35 publications

(21 citation statements)

References 37 publications

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“…Here no differences in the amount of CD45 + cells in the isolated cell populations were found. At day 7 no differences in phagocytic activity of the intestinal mononuclear cells were found, which is in agreement with an earlier study [12]. Unfortunately in that study, no earlier timepoints than day 7 pi were investigated.…”

Section: Discussionsupporting

confidence: 92%

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Immunological and gene expression responses to aSalmonellainfection in the chicken intestine

et al. 2007

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-Besides infection in humans, Salmonella enteritidis can also cause serious illness in young chickens. However, the genetic and immunological parameters important for the disease in chickens are not well characterized. In this study, processes in the chicken intestine in response to a Salmonella infection were investigated in two different chicken lines. One-day-old chickens were orally infected with Salmonella. T-cell subpopulations, phagocytic properties of intestinal mononuclear cells and RNA expression levels of the jejunum were investigated. The two chicken lines differed in the amount of cfu in the liver and growth retardation after the infection. Differences in phagocytic activity of intestinal mononuclear cells were found between control and Salmonella infected chickens. The number of CD4 + T-cells of the intestine decreased after the Salmonella infection in one chicken line, while the number of CD8 + T-cells increased in both chicken lines, but the time post infection of this increase differed between the lines. In one chicken line the expression levels of the genes carboxypeptidase M and similar to ORF2 decreased after the Salmonella infection, which might be related to a decrease in the amount of macrophages. With the microarray, ten genes were found that were regulated in only one of the chicken lines, while we found six genes regulated in response to the infection in both chicken lines. So differences in genetic background of the chickens influence the intestinal host response of the Salmonella infection as observed by phagocytic activity, gene expression and changes in the number of T-cell subpopulations and macrophages.immunology / microarray / Salmonella / T-cell

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Section: Discussionsupporting

confidence: 92%

“…The intestinal mononuclear cell isolates were tested for their phagocytic activity by intake of live Salmonella enteritidis phage type 4 as described by Kramer et al [12]. Briefly, the gut mononuclear cell suspension was diluted to 1 × 10 7 cells/mL in RPMI.…”

Section: Phagocyte Activity Of Intestinal Mononuclear Cellsmentioning

confidence: 99%

Immunological and gene expression responses to aSalmonellainfection in the chicken intestine

et al. 2007

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“…Certain lines are more resistant than others to intestinal carriage (DuchetSuchaux et al, 1997) or to systemic infection and mortality (Bumstead and Barrow, 1988). An inverse correlation has been reported between severity of caecal infection and severity of systemic infection in different broiler lines (Kramer et al, 2001). …”

Section: Laying Hens and Eggs For Human Consumptionmentioning

confidence: 94%

Opinion of the Scientific Panel on biological hazards (BIOHAZ) related to the use of vaccines for the control of Salmonella in poultry

2004

EFSA Journal

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“…Certain lines are more resistant than others to intestinal carriage (Duchet-Suchaux et al, 1997) or to systemic infection and mortality (Bumstead and Barrow, 1988). An inverse correlation has been reported between severity of caecal infection and severity of systemic infection in different broiler lines (Kramer et al, 2001). …”

Section: Clinical Salmonella Infections In Poultrymentioning

confidence: 94%

Opinion of the Scientific Panel on biological hazards (BIOHAZ) related to the use of antimicrobials for the control of Salmonella in poultry

2004

EFSA Journal

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Characterization of the innate and adaptive immunity to Salmonella enteritidis PT1 infection in four broiler lines

Cited by 35 publications

References 37 publications

Immunological and gene expression responses to aSalmonellainfection in the chicken intestine

Immunological and gene expression responses to aSalmonellainfection in the chicken intestine

Opinion of the Scientific Panel on biological hazards (BIOHAZ) related to the use of vaccines for the control of Salmonella in poultry

Opinion of the Scientific Panel on biological hazards (BIOHAZ) related to the use of antimicrobials for the control of Salmonella in poultry

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