Characterization of the human myocardium by optical coherence tomography

Gan, Yu; Lye, Theresa H.; Marboe, Charles C.; Hendon, Christine P.

doi:10.1002/jbio.201900094

Cited by 16 publications

(10 citation statements)

References 47 publications

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“…The urinary bladder wall, for example, consists of the urothelium or mucosa, placed on a connective tissue layer called lamina propria and the muscularis propria 29 . Performing OCT measurements on the inner bladder wall, will result in reduced signal intensity coming from the urothelium and the muscularis layer 31 , while connective tissue, on the other hand, consisting among other components of collagen fibers, will lead to higher OCT signals originating from this layer 32 – 34 . In contrast, deposits of fatty tissue could result in very low OCT signal, as reported in breast tumor imaging 35 – 37 .…”

Section: Introductionmentioning

confidence: 99%

Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis

Schie

Placzek

Knorr

et al. 2021

Sci Rep

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The combination of manifold optical imaging modalities resulting in multimodal optical systems allows to discover a larger number of biomarkers than using a single modality. The goal of multimodal imaging systems is to increase the diagnostic performance through the combination of complementary modalities, e.g. optical coherence tomography (OCT) and Raman spectroscopy (RS). The physical signal origins of OCT and RS are distinctly different, i.e. in OCT it is elastic back scattering of photons, due to a change in refractive index, while in RS it is the inelastic scattering between photons and molecules. Despite those diverse characteristics both modalities are also linked via scattering properties and molecular composition of tissue. Here, we investigate for the first time the relation of co-registered OCT and RS signals of human bladder tissue, to demonstrate that the signals of these complementary modalities are inherently intertwined, enabling a direct but more importantly improved interpretation and better understanding of the other modality. This work demonstrates that the benefit for using two complementary imaging approaches is, not only the increased diagnostic value, but the increased information and better understanding of the signal origins of both modalities. This evaluation confirms the advantages for using multimodal imaging systems and also paves the way for significant further improved understanding and clinically interpretation of both modalities in the future.

show abstract

Section: Introductionmentioning

confidence: 99%

Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis

Schie

Placzek

Knorr

et al. 2021

Sci Rep

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show abstract

“…Optical coherence tomography (OCT) and polarization‐sensitive OCT are used to characterize the optical properties and the birefringence property of tissue. Tissue optical properties containing total attenuation, scattering coefficients and optical thickness can be noninvasive measured based on OCT. [ 11–14 ] Cumulative or local phase retardance and optical axis can be obtained based on polarization sensitive (PS)‐OCT. [ 15–18 ]…”

Section: Introductionmentioning

confidence: 99%

Orthogonal‐polarization‐gating optical coherence tomography for human sweat ducts in vivo

Zhang

et al. 2021

Journal of Biophotonics

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We propose an orthogonal‐polarization‐gating optical coherence tomography (OPG‐OCT) for human sweat ducts in vivo. OPG‐OCT is composed of the orthogonal linearly polarized light of a sample arm individually interfering with orthogonal linearly polarized lights of the reference arms, where OPG‐OCT induces two images, one reflecting the projection intensity and the other the horizontal linear diattenuation (HLD). The results demonstrate that OPG‐OCT projection intensity could improve the image quality of sweat ducts. HLD also clearly illustrates the spiral shape of the sweat ducts. Finally, sweat ducts in intensity image are segmented by employing convolutional neural networks (CNN). The proportions of left‐handed and right‐handed ducts are extracted to characterize the sweat ducts based on HLD. Therefore, the OPG‐OCT technique employing CNN for the human sweat glands has the potential to automatically identify the human sweat ducts in vivo.

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“…The urinary bladder wall, for example, consists of the urothelium or mucosa, placed on a connective tissue layer called lamina propria and the muscularis propria 29 . Performing OCT measurements on the inner bladder wall, will result in reduced signal intensity coming from the urothelium and the muscularis layer 31 , while connective tissue, on the other hand, consisting among other components of collagen bers, will lead to higher OCT signals originating from this layer [32][33][34] . In contrast, deposits of fatty tissue could result in very low OCT signal, as reported in breast tumor imaging [35][36][37] .…”

Section: Introductionmentioning

confidence: 99%

Morpho-molecular Signal Correlation between Optical Coherence Tomography and Raman Spectroscopy for Superior Image Interpretation and Clinical Diagnosis

Schie

Placzek

Knorr

et al. 2021

Preprint

View full text Add to dashboard Cite

The combination of manifold optical imaging modalities resulting in multimodal optical systems allows to discover a larger number of biomarkers than using a single modality. The goal of multimodal imaging systems is to increase the diagnostic performance through the combination of complementary modalities, e.g. optical coherence tomography (OCT) and Raman spectroscopy (RS). The physical signal origins of OCT and RS are distinctly different, i.e. in OCT it is elastic back scattering of photons, due to a change in refractive index, while in RS, it is the inelastic scattering between photons and molecules. Despite those diverse characteristics both modalities are also linked via scattering properties and molecular composition of tissue. Here, we investigate for the first time the relation of co-registered OCT and RS signals of human bladder tissue, to demonstrate that the signals of these complementary modalities are inherently intertwined, enabling a direct but more importantly improved interpretation and better understanding of the other modality. This work demonstrates that the benefit for using two complementary imaging approaches is, not only the increased diagnostic value, but the increased information and better understanding of the signal origins of both modalities. This evaluation confirms the advantages for using multimodal imaging systems and also paves the way for significant further improved understanding and clinically interpretation of both modalities in the future.

show abstract

Characterization of the human myocardium by optical coherence tomography

Cited by 16 publications

References 47 publications

Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis

Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis

Orthogonal‐polarization‐gating optical coherence tomography for human sweat ducts in vivo

Morpho-molecular Signal Correlation between Optical Coherence Tomography and Raman Spectroscopy for Superior Image Interpretation and Clinical Diagnosis

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