Characterization of the HSD17B4 gene: d-specific multifunctional protein 2/17β-hydroxysteroid dehydrogenase IV

Möller, Gabriele; Leenders, Frauke; Grunsven, Elisabeth E.G. Van; Dolez, Vincent V.; Qualmann, Britta; Kessels, Michael M.; Markus, Monika; Krazeisen, Antje; Husen, Bettina; Wanders, Ronald J. A.; Launoit, Yvan de; Adamski, Jerzy

doi:10.1016/s0960-0760(99)00066-7

Cited by 26 publications

(15 citation statements)

References 29 publications

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“…When looking at the protein interactions that form the interactions between these pathways, it turns out to be comprised of two binding interactions between Hadh , Hsd17b10 and Hsd17b4 (Additional file 1, Figure S7). These binding interactions are assigned by the STRING database [15] as subunits of a single enzyme complex, but in reality they are three distinct isozymes of 3-hydroxyacyl-CoA dehydrogenase [16,17]. Therefore, these proteins are probably not binding, but rather catalyzing a similar reaction in each of these pathways.…”

Section: Resultsmentioning

confidence: 99%

Exploring pathway interactions in insulin resistant mouse liver

Kelder

Eijssen

Kleemann³

et al. 2011

BMC Systems Biology

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BackgroundComplex phenotypes such as insulin resistance involve different biological pathways that may interact and influence each other. Interpretation of related experimental data would be facilitated by identifying relevant pathway interactions in the context of the dataset.ResultsWe developed an analysis approach to study interactions between pathways by integrating gene and protein interaction networks, biological pathway information and high-throughput data. This approach was applied to a transcriptomics dataset to investigate pathway interactions in insulin resistant mouse liver in response to a glucose challenge. We identified regulated pathway interactions at different time points following the glucose challenge and also studied the underlying protein interactions to find possible mechanisms and key proteins involved in pathway cross-talk. A large number of pathway interactions were found for the comparison between the two diet groups at t = 0. The initial response to the glucose challenge (t = 0.6) was typed by an acute stress response and pathway interactions showed large overlap between the two diet groups, while the pathway interaction networks for the late response were more dissimilar.ConclusionsStudying pathway interactions provides a new perspective on the data that complements established pathway analysis methods such as enrichment analysis. This study provided new insights in how interactions between pathways may be affected by insulin resistance. In addition, the analysis approach described here can be generally applied to different types of high-throughput data and will therefore be useful for analysis of other complex datasets as well.

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Section: Resultsmentioning

confidence: 99%

Exploring pathway interactions in insulin resistant mouse liver

Kelder

Eijssen

Kleemann³

et al. 2011

BMC Systems Biology

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“…17HSD/KSR4 is ubiquitously expressed, but in some tissues it shows cell-specific expression. In brain it is present only in Purkinje cells, in the lung only in bronchial epithelium and in the uterus in luminal and glandular epithelium (Kaufmann et al 1995, Möller et al 1999. Deficiency of 17HSD/ KSR4 leads to the disease known as Zellweger syndrome (Novikov et al 1997, van Grunsven et al 1998.…”

Section: Hsd/ksr4mentioning

confidence: 99%

17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes

Peltoketo¹,

Luu‐The²,

Simard³

et al. 1999

Journal of Molecular Endocrinology

275

164

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“…The human HSD17B4 gene contains three domains: the N-terminal short-chain alcohol dehydrogenase domain, the central hydratase domain, and the C-terminal sterol carrier protein 2 (SCP2) domain. The dehydrogenase domain is involved in the oxidative inactivation of E 2 , and all three domains are involved in peroxisomal b-oxidation of fatty acids (36,37). Abnormal expression of HSD17B4 has been associated with several cancers (38,39).…”

Section: Discussionmentioning

confidence: 99%