Characterization of the fecal microbiota in gastrointestinal cancer patients and healthy people

Li, Ningning; Bai, Chunmei; Zhao, Lin; Ge, Yuping; Li, Xiaoyuan

doi:10.1007/s12094-021-02754-y

Cited by 16 publications

(11 citation statements)

References 54 publications

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“…Those results involved a five‐fold cross‐validation for data preparation of a random forest mode in a single study gathering 73 participants with 76% of patients diagnosed at more advanced stages of the disease. Additionally, two models including fecal microbiota achieved AUC values of 0.97 and 0.94, the latter involving cross‐validation for data preparation 23,34 . None of the remaining biomarkers included in Table 2 were validated.…”

Section: Resultsmentioning

confidence: 99%

“…All the included reports in stool samples were performed in Asian populations, seven in China 23 , 30 , 31 , 32 , 33 , 34 , 35 and one in Iran, 36 and were case‐control studies. Overall, four biomarkers were explored: (a) fecal calprotectin in two studies 33 , 36 ; (b) B‐cell activating factor (BAFF) protein in one study 33 ; (c) telomerase reverse transcriptase ( TERT ) gene promoter methylation in one population 30 and (d) the fecal microbiota was explored in five Chinese populations, 23 , 31 , 32 , 34 , 35 either targeting bacterial 16S ribosomal RNA (rRNA) and fungal 18S rRNA or bacterial DNA. Stool‐based biomarkers with reported expression in GC, as well as AUC values, are summarized in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, two models including fecal microbiota achieved AUC values of 0.97 and 0.94, the latter involving cross‐validation for data preparation. 23 , 34 None of the remaining biomarkers included in Table 2 were validated.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Gastric cancer detection by non‐blood‐based liquid biopsies: A systematic review looking into the last decade of research

et al. 2022

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Gastric cancer (GC) screening is arguable in most Western countries. Liquid biopsies are a great promise to answer the unmet need for less invasive diagnostic biomarkers in GC. Thus, we aimed at systematically reviewing the current knowledge on liquid biopsy-based biomarkers in GC screening. A systematic search on PubMed/MEDLINE and Scopus databases was performed on published articles reporting the use of non-blood specimen (saliva, gastric juice [GJ], urine and stool) on GC diagnosis. 3208 records were retrieved by June 2022. After removal of duplicate records, 2379 abstracts were screened, and 84 full texts included in this systematic review. More than 90% of studies were reported on Asian populations.Overall, 9 studies explored stool-, 12 saliva-, and 29 urine-derived biomarkers for GC detection. Additionally, 37 studies, representing the majority, analyzed GJ, focusing on nucleic acid molecules. Several miRNAs and lncRNA molecules have been associated with GC risk, particularly miR-21 (area under the curve [AUC] = 0.97, 95% CI: 0.94-1.00). Considering salivary biomarkers, the best described model in validation sets included the soybean agglutinin and Vicia villosa agglutinin lectins (AUC = 0.89, 95% CI: 0.80-0.99). Most studies in urine carried out metabolomic approaches, with two discriminatory models presenting AUC values superior to 0.97. This systematic review emphasizes the potential role of non-blood-based biomarkers, although further validation, particularly in Western countries, is mandatory, namely for noninvasive screening and/or monitoring, as well as the use of GJ as a tool to enhance upper gastrointestinal endoscopy accuracy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Gastric cancer detection by non‐blood‐based liquid biopsies: A systematic review looking into the last decade of research

et al. 2022

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“…Klebsiella oxytocin colonization in mice led to a similar outcome with increased anxiety-like phenotype following increased inflammation through NF-kB-dependent pathways ( 28 ). Faecalibacterium is widely thought to defend against gastrointestinal and extraintestinal diseases ( 29 ), and also appears to be beneficial to overall health, minimizing the occurrence of metabolic disorders as well as a variety of chronic diseases and inflammatory pathologies ( 30 ). Our study showed that the abundance of Faecalibacterium was reduced in AUD patients, indicating that alcohol consumption can destroy beneficial bacteria in the gut, rendering the microbiota detrimental to the human body and weakening their protective functions.…”

Section: Discussionmentioning

confidence: 99%

The diversity of the intestinal microbiota in patients with alcohol use disorder and its relationship to alcohol consumption and cognition

Gong

et al. 2022

Front. Psychiatry

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IntroductionAlcohol use disorder (AUD) has evolved into a severe social and medical issue. However, the exact environmental factors triggering AUD pathophysiology remain unknown. A growing body of research has shown that environmental elements can affect the brain via the microbiota-gut-brain axis.MethodsWe employed 16S rRNA gene sequencing technology to investigate the composition and diversity of intestinal microbiota in 32 AUD males and 35 healthy controls (HCs), as well as its relationship on cognitive function.ResultsOur findings showed that the alpha diversity indices in AUDs were much lower than HCs. The abundances of Faecalibacterium, Gemmiger, Lachnospiracea_incertae_sedis, Megamonas, and Escherichia were significantly different between AUD and HC groups and could be used as a basis for judging whether excessive drinking. The abundances of Faecalibacterium, Gemmiger, Escherichia, and Fusobacterium can be used to judge the cognitive function of the population.ConclusionThese data suggested that the gut dysbiosis in AUD patients, and some specific microbiota were considered to be related to alcohol intake and cognitive function. This study provides important information for further study of the pathogenesis of AUD from the perspective of intestinal microbiota.

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“…Conversely, it was observed that A. muciniphila abundance was heavily increased in two different cohorts of patients affected by CRC, as well as in a cohort of patients with esophageal and gastric cancers compared with healthy controls [77,78]. However, according to Weil et al, this observation can be related to an increased substrate availability rather than to a detrimental role of this bacterium, considering the overexpression of MUC1 and MUC5AC in CRCs [78].…”

Section: Akkermansia Muciniphila and Cancermentioning

confidence: 95%

Role of Akkermansia in Human Diseases: From Causation to Therapeutic Properties

et al. 2023

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The gut microbiota plays a critical role in the modulation of host metabolism and immune response, and its impairment has been implicated in many gastrointestinal and extraintestinal diseases. Current evidence shows the well-documented role of A. muciniphila in maintaining the integrity of the intestinal barrier, modulating the host immune response, and improving several metabolic pathways, making it a key element in the pathogenesis of several human diseases. In this scenario, A. muciniphila is the most promising next-generation probiotic and one of the first microbial species suitable for specific clinical use when compared with traditional probiotics. Further studies are needed to provide more accurate insight into its mechanisms of action and to better elucidate its properties in several major areas, paving the way for a more integrated and personalized therapeutic approach that finally makes the most of our knowledge of the gut microbiota.

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Characterization of the fecal microbiota in gastrointestinal cancer patients and healthy people

Cited by 16 publications

References 54 publications

Gastric cancer detection by non‐blood‐based liquid biopsies: A systematic review looking into the last decade of research

Gastric cancer detection by non‐blood‐based liquid biopsies: A systematic review looking into the last decade of research

The diversity of the intestinal microbiota in patients with alcohol use disorder and its relationship to alcohol consumption and cognition

Role of Akkermansia in Human Diseases: From Causation to Therapeutic Properties

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