2004
DOI: 10.1073/pnas.0405571101
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Characterization of the ERβ /–mouse heart

Abstract: Although the heart responds to estrogen, it is not clear whether estrogen acts directly on heart muscle or indirectly by means of the vascular, immune, or nervous system. No role for estrogen receptor (ER) β in the heart has been established, but ERβ –/– mice are hypertensive, and as they age, their hearts become enlarged. Histological and ultrastructural analysis of the heart revealed a disarray of myocytes, a disruption of intercalated discs, an increase in the number and size of gap … Show more

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Cited by 63 publications
(52 citation statements)
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“…29,30 In contrast to previous studies, which failed to detect measurable amounts of ER␣ and ER␤ protein in the mouse heart, several independent studies reported on robust cardiac expression levels of both ER subtypes in rats and humans. 10,31,32 However, cardiac expression levels of ER␣ and ER␤ may not only vary between different species but also among young and senescent SHRs. Therefore, it is interesting to note that cardiac ER␣ expression was significantly lower in sham-operated and ovariectomized aged rats, whereas ER␤ was detected at comparable amounts in the heart of young and senescent rats.…”
Section: Discussionmentioning
confidence: 99%
“…29,30 In contrast to previous studies, which failed to detect measurable amounts of ER␣ and ER␤ protein in the mouse heart, several independent studies reported on robust cardiac expression levels of both ER subtypes in rats and humans. 10,31,32 However, cardiac expression levels of ER␣ and ER␤ may not only vary between different species but also among young and senescent SHRs. Therefore, it is interesting to note that cardiac ER␣ expression was significantly lower in sham-operated and ovariectomized aged rats, whereas ER␤ was detected at comparable amounts in the heart of young and senescent rats.…”
Section: Discussionmentioning
confidence: 99%
“…3). ER expression, as measured by [ 3 H]E 2 binding, in breast tumors ranges between 10-1000 fmol/mg nuclear protein (0.01-1fmol/mg) and 2-3 pmol/mg (2-3 fmol/mg) cytosolic protein (Forster et al 2004 Our results in lung adenocarcinoma differ from breast cancer where progression to estrogen independence and anti-estrogen resistance is often associated with decreased ERa expression (Yang et al 2001); the results also differ from endometrial and ovarian cancer where the ERb : ERa ratio is decreased compared with the respective non-cancer tissues (Pujol et al 1998, Fujimoto et al 2000, Li et al 2003. Moreover, E 2 binding was higher in NEs compared with CEs, indicating that sequestration of ER outside the nucleus does not appear to be the cause of the lack of ER responses in the adenocarcinoma cells from males.…”
Section: Discussionmentioning
confidence: 99%
“…ER is the more expressed receptor in central nervous and cardiovascular systems, and prostate gland, whereas ER plays a dominant role in mammary gland and uterus (Couse et al 1997, Forster et al 2004. ER is believed to play a central role in the origin and progression of breast cancer; however, recent studies suggest that ER can suppress breast cancer progression (Paruthiyil et al 2004, Strom et al 2004.…”
Section: Thermal Unfolding and Conformational Dynamics Of Er And Er ·mentioning
confidence: 99%