Characterization of the env gene and long terminal repeat of molecularly cloned Friend mink cell focus-inducing virus DNA

Adachi, Akio; Sakai, Kyoko; Kitamura, Naomi; Nakanishi, S; Niwa, Osami; Matsuyama, Mutsushi; Ishimoto, Akinori

doi:10.1128/jvi.50.3.813-821.1984

Cited by 61 publications

(28 citation statements)

References 45 publications

(46 reference statements)

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“…We previously reported the isolation of a molecular clone consisting of the 5' 6.7 kilobases (kb) of the NFS-Th- 1 xenotropic provirus (7) and the nucleotide sequence of 863 base pairs (bp) encompassing portions of the pol and enm genes (39). The 5' 573 bp of the env gene present in this clone of an incomplete xenotropic provirus contained several insertions and deletions relative to the analogous portion of the env region in AKR and Moloney ecotropic MuLVs (39).…”

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confidence: 99%

“…This xenotropic MuLV (NZB-IU-6) is different from the xenotropic MuLV that is spontaneously expressed in NZB mice (11). The nucleotide sequence of the entire env gene is presented and compared with previously published enm' sequences of MCF and ecotropic MuLVs (1,6,19,24,28,29,41). In addition, we report the sequence of the 3' portion of the pol gene, the long terminal repeat (LTR), and the adjacent 5' untranslated gag leader region encoding the * Corresponding author.…”

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confidence: 99%

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Envelope and long terminal repeat sequences of a cloned infectious NZB xenotropic murine leukemia virus

O'Neill¹,

Buckler²,

Theodore³

et al. 1985

J Virol

101

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An infectious NZB xenotropic murine leukemia virus (MuLV) provirus (NZB9-1) was molecularly cloned from the Hirt supernatant of NZB-IU-6-infected mink cells, and the nucleotide sequence of its env gene and long terminal repeat (LTR) was determined. The partial nucleotide sequence previously reported for the env gene of NFS-Th-1 xenotropic proviral DNA (Repaske, et al., J. Virol. 46:204-211, 1983) is identical to that of the infectious NZB xenotropic MuLV DNA reported here. Alignment of nucleotide or deduced amino acid sequences, or both, of xenotropic, mink cell focus-forming, and ecotropic MuLV proviral DNAs in the env region identified sequence differences among the three host range classes of C-type MuLVs. Major differences were confined to the 5' half of env; a high degree of homology was found among the three classes of MuLVs in the 3' half of env. Alignment of the nucleotide sequence of the LTR of NZB9_1 xenotropic MuLV with those of the LTRs of NFS-Th-l xenotropic, mink cell focus-forming, and ecotropic MuLVs revealed extensive homology between the LTRs of xenotropic and MCF247 MuLVs. An inserted 6-base-pair repeat 5' to the TATA box was a unique feature of both NZB9-1 and NFS-Th-l xenotropic LTRs.

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confidence: 99%

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confidence: 99%

Envelope and long terminal repeat sequences of a cloned infectious NZB xenotropic murine leukemia virus

O'Neill¹,

Buckler²,

Theodore³

et al. 1985

J Virol

101

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“…MCF-like viruses have also been recovered from feline (Neil et aL, 1991) and avian oncogene-murine chimeric systems (Feuer et aL,i993). Other references that provide a useful entry to this field include Adachi et al (1984), Chattopadhyay et aL (1991), Di Fronzo and Holland (1993), Khan et aL (1987), Koch et aL (1984), Levy et al (1985), Makino et al (1990), Oliff et al (1984), Quint et al (1984) and Shields et al (1991).…”

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confidence: 99%

Reflections on scrapie and related disorders, with consideration of the possibility of a viral aetiology

Darcel¹

1995

Vet Res Commun

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The transmissible spongiform encephalopathies of domesticated animals, scrapie in sheep and bovine spongiform encephalopathy (BSE), and transmissible mink encephalopathy are more than a scientific curiosity; under certain circumstances their impact on commercial activities can be calamitous. Knowledge of their causation and pathogenesis is still rudimentary, but many consider than an unconventional agent, the prion (a brain protein, PrP), that is not associated with nucleic acid is involved in both. Others believe that conventional viruses, which replicate by virtue of their nucleic acid-defined genes, are involved in the causation and progression of the encephalopathies but that technical problems have prevented their identification. Others postulate even more exotic causative agents. While this paper will particularly address the possibility of a viral aetiology for these diseases, it is also emphasized that our knowledge of the state of the immune system in animals with encephalopathy needs broadening. There are remarkable gaps in our knowledge of the histopathology of these diseases, particularly the nature of the characteristic vacuoles. Much further work is needed on the biochemical changes in the brain and the serum, particularly of the latter as it could lead to an additional means of recognizing clinical cases without waiting for the animal to die with subsequent examination of the brain for characteristic lesions and the presence of protease-K-resistant PrP.

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“…Mice inoculated with exogenous ecotropic murine leukemia viruses (MuLVs) or mice expressing endogenous ecotropic MuLVs frequently generate polytropic viruses which have been implicated in the induction of a number of proliferative diseases in mice (1,3,15,16,18,21,22,25,30). These viruses, also termed dualtropic or mink cell focus-forming MuLVs, utilize a cellular receptor different from that used by ecotropic MuLVs and exhibit a distinct host range (22,38).…”

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A small region of the ecotropic murine leukemia virus (MuLV) gag gene profoundly influences the types of polytropic MuLVs generated in mice

Lavignon

Richardson

Evans

1997

J Virol

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The vast majority of recombinant polytropic murine leukemia viruses (MuLVs) generated in mice after infection by ecotropic MuLVs can be classified into two major antigenic groups based on their reactivities to two monoclonal antibodies (MAbs) termed Hy 7 and 516. These groups very likely correspond to viruses formed by recombination of the ecotropic MuLV with two distinct sets of polytropic env genes present in the genomes of inbred mouse strains. We have found that nearly all polytropic MuLVs identified in mice infected with a substrain of Friend MuLV (F-MuLV 57 ) are reactive with Hy 7, whereas mice infected with Moloney MuLV (Mo-MuLV) generate major populations of both Hy 7-and 516-reactive polytropic MuLVs. We examined polytropic MuLVs generated in NFS/N mice after inoculation with Mo-MuLV-F-MuLV 57 chimeras to determine which regions of the viral genome influence this difference between the two ecotropic MuLVs. These studies identified a region of the MuLV genome which encodes the nucleocapsid protein and a portion of the viral protease as the only region that influenced the difference in polytropic-MuLV generation by Mo-MuLV and F-MuLV 57 .

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Characterization of the env gene and long terminal repeat of molecularly cloned Friend mink cell focus-inducing virus DNA

Cited by 61 publications

References 45 publications

Envelope and long terminal repeat sequences of a cloned infectious NZB xenotropic murine leukemia virus

Envelope and long terminal repeat sequences of a cloned infectious NZB xenotropic murine leukemia virus

Reflections on scrapie and related disorders, with consideration of the possibility of a viral aetiology

A small region of the ecotropic murine leukemia virus (MuLV) gag gene profoundly influences the types of polytropic MuLVs generated in mice

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