Characterization of the effects of cannabinoid receptor deletion on energy metabolism in female C57BL mice
Morgan Sotzen,
Ahmed Ahmed,
L. Karl Olson
et al.
Abstract:BackgroundDespite the evidence that energy balance is regulated differently in females and that the endocannabinoid system is sexually dimorphic, previous studies on the endocannabinoid system and energy balance predominantly used male models. Here, we characterize the effects of cannabinoid receptor deletion on body weight gain and glucose metabolism in female C57BL mice.MethodsFemale mice lacking the cannabinoid-1 receptor (CB1R-/-), cannabinoid-2 receptor (CB2R-/-), or both receptors (CB1R-/-/CB2R-/-) and w… Show more
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