Characterization of the Effects of Adenosine Receptor Agonists on Cerebral Blood Flow in Uninjured and Traumatically Injured Rat Brain using Continuous Arterial Spin-Labeled Magnetic Resonance Imaging

Kochanek, Patrick M.; Hendrich, Kristy; Jackson, Edwin K.; Wisniewski, Stephen R.; Mendeloff, John; Shore, Paul; Janesko, Keri L.; Zacharia, Lefteris C.; Ho, Chien

doi:10.1038/sj.jcbfm.9600154

Cited by 32 publications

(21 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, one should not forget the neurodegererative and toxic effects that A 2A ARs exert at the central level [43][44][45][46][47][48][49]. In this context, A 2A AR hyperactivity may have important pathophysiological implications and might contribute to, induce or exacerbate neurodegenerative effects in several psychiatric diseases.…”

Section: Resultsmentioning

confidence: 99%

Receptor crosstalk: haloperidol treatment enhances A2A adenosine receptor functioning in a transfected cell model

Trincavelli

Cuboni

Dell’Osso

et al. 2010

Purinergic Signalling

View full text Add to dashboard Cite

A 2A adenosine receptors are considered an excellent target for drug development in several neurological and psychiatric disorders. It is noteworthy that the responses evoked by A 2A adenosine receptors are regulated by D 2 dopamine receptor ligands. These two receptors are coexpressed at the level of the basal ganglia and interact to form functional heterodimers. In this context, possible changes in A 2A adenosine receptor functional responses caused by the chronic blockade/activation of D 2 dopamine receptors should be considered to optimise the therapeutic effectiveness of dopaminergic agents and to reduce any possible side effects. In the present paper, we investigated the regulation of A 2A adenosine receptors induced by antipsychotic drugs, commonly acting as D 2 dopamine receptor antagonists, in a cellular model co-expressing both A 2A and D 2 receptors. Our data suggest that the treatment of cells with the classical antipsychotic haloperidol increased both the affinity and responsiveness of the A 2A receptor and also affected the degree of A 2A -D 2 receptor heterodimerisation. In contrast, an atypical antipsychotic, clozapine, had no effect on A 2A adenosine receptor parameters, suggesting that the two classes of drugs have different effects on adenosinedopamine receptor interaction. Modifications to A 2A adenosine receptors may play a significant role in determining cerebral adenosine effects during the chronic administration of antipsychotics in psychiatric diseases and may account for the efficacy of A 2A adenosine receptor ligands in pathologies associated with dopaminergic system dysfunction.

show abstract

Section: Resultsmentioning

confidence: 99%

Receptor crosstalk: haloperidol treatment enhances A2A adenosine receptor functioning in a transfected cell model

Trincavelli

Cuboni

Dell’Osso

et al. 2010

Purinergic Signalling

View full text Add to dashboard Cite

show abstract

“…There are now at least four different variations on ASL including continuous ASL (CASL) (Detre and Alsop, 1999), pulsed ASL (PASL), cPASL (continuous PASL), and velocity selected ASL (VSASL) . ASL has been used to study rodent models of TBI (Forbes et al, 1997a,b;Hendrich et al, 1999;Kochanek et al, 2002Kochanek et al, , 2005Robertson et al, 2000), and has recently also been used in patient studies . Several promising potential applications for ASL in the study of TBI have been proposed, including characterization of regional brain function in severe TBI in which task-evoked responses are difficult to obtain, determination of the relationship between changes in regional CBF and cognitive deficits to identify potential targets for pharmacological therapy or other intervention, and use as a biomarker for pharmaceutical trials (Van Boven et al, 2009).…”

Section: Perfusion Imagingmentioning

confidence: 99%

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Hunter

Wilde

Tong

et al. 2012

Journal of Neurotrauma

114

View full text Add to dashboard Cite

This article identifies emerging neuroimaging measures considered by the inter-agency Pediatric Traumatic Brain Injury (TBI) Neuroimaging Workgroup. This article attempts to address some of the potential uses of more advanced forms of imaging in TBI as well as highlight some of the current considerations and unresolved challenges of using them. We summarize emerging elements likely to gain more widespread use in the coming years, because of 1) their utility in diagnosis, prognosis, and understanding the natural course of degeneration or recovery following TBI, and potential for evaluating treatment strategies; 2) the ability of many centers to acquire these data with scanners and equipment that are readily available in existing clinical and research settings; and 3) advances in software that provide more automated, readily available, and cost-effective analysis methods for large scale data image analysis. These include multi-slice CT, volumetric MRI analysis, susceptibility-weighted imaging (SWI), diffusion tensor imaging (DTI), magnetization transfer imaging (MTI), arterial spin tag labeling (ASL), functional MRI (fMRI), including resting state and connectivity MRI, MR spectroscopy (MRS), and hyperpolarization scanning. However, we also include brief introductions to other specialized forms of advanced imaging that currently do require specialized equipment, for example, single photon emission computed tomography (SPECT), positron emission tomography (PET), encephalography (EEG), and magnetoencephalography (MEG)/magnetic source imaging (MSI). Finally, we identify some of the challenges that users of the emerging imaging CDEs may wish to consider, including quality control, performing multi-site and longitudinal imaging studies, and MR scanning in infants and children.

show abstract

“…Thus, there are short term adaptive neuronal responses that are operated through inhibitory A 1 receptors, namely in terms of the slow wave sleep [114] and cerebral metabolic activity [115,116]. There are also more long term adaptive changes, such as up-regulation of A 1 receptors [117,119] and possibly of A 2A receptors (reviewed in [57]) the former being a strong candidate to mediate the reduction of cerebral blood flow [116,[120][121][122], which is observed after these treatments. It should be made clear that at this stage there is a tentative parallel between the effects operated by these mood disorder treatments and the adenosine modulation system in the brain, but it still remain to be directly shown that the mood beneficial effects of these treatments is hampered by manipulation of adenosine receptors.…”

Section: Adenosine and Mood Disordersmentioning

confidence: 99%

Potential Therapeutic Interest of Adenosine A2A Receptors in Psychiatric Disorders

Cunha¹,

Ferré²,

Vaugeois³

et al. 2008

CPD

174

149

View full text Add to dashboard Cite

The interest on targeting adenosine A 2A receptors in the realm of psychiatric diseases first arose based on its tight physical and functional interaction with dopamine D 2 receptors. However, the role of central A 2A receptors is now viewed as much broader than just controlling D 2 receptor function. Thus, there is currently a major interest in the ability of A 2A receptors to control synaptic plasticity at glutamatergic synapses. This is due to a combined ability of A 2A receptors to facilitate the release of glutamate and the activation of NMDA. Therefore, A 2A receptors are now conceived as a normalizing device promoting adequate adaptive responses in neuronal circuits, a role similar to that fulfilled, in essence, by dopamine. This makes A 2A receptors a particularly attractive target to manage psychiatric disorders since adenosine may act as go-between glutamate and dopamine, two of the key players in mood processing. Furthermore, A 2A receptors also control glia function and brain metabolic adaptation, two other emerging mechanisms to understand abnormal processing of mood, and A 2A receptors are an important player in controlling the demise of neurodegeneration, considered an amplificatory loop in psychiatric disorders. Current data only provide an indirect confirmation of this putative role of A 2A receptors, based on the effects of caffeine (an antagonist of both A 1 and A 2A receptors) in psychiatric disorders. However, the introduction of A 2A receptors in clinics as antiparkinsonian agents is hoped to bolster our knowledge on the role of A 2A receptors in mood disorders in the near future.

show abstract

Characterization of the Effects of Adenosine Receptor Agonists on Cerebral Blood Flow in Uninjured and Traumatically Injured Rat Brain using Continuous Arterial Spin-Labeled Magnetic Resonance Imaging

Cited by 32 publications

References 67 publications

Receptor crosstalk: haloperidol treatment enhances A2A adenosine receptor functioning in a transfected cell model

Receptor crosstalk: haloperidol treatment enhances A2A adenosine receptor functioning in a transfected cell model

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Potential Therapeutic Interest of Adenosine A2A Receptors in Psychiatric Disorders

Contact Info

Product

Resources

About