Characterization of the DGAT1 gene in the Indian buffalo (Bubalus bubalis)

Mishra, Bina; Tantia, M. S.; Kumar, S T Bharani; Vijh, R. K.

doi:10.1590/s1415-47572007000600012

Cited by 11 publications

(12 citation statements)

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“…Several studies reported single nucleotide polymorphisms (SNPs) in the buffalo DGAT1 gene (Tantia et al 2006;Mishra et al 2007;Raut et al 2012;Venkatachalapathy et al 2013, Cardoso et al 2015. Some studies showed the influence of SNPs in production traits in cattle.…”

Section: Introductionmentioning

confidence: 99%

Genetic association between SNPs in the DGAT1 gene and milk production traits in Murrah buffaloes

Freitas

Camargo

Stafuzza

et al. 2016

Trop Anim Health Prod

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This study identified polymorphisms in the DGAT1 gene in Murrah buffaloes and investigated the associations to milk production and quality traits (milk, fat and protein yields and percentages, somatic cell count). Genomic DNA was extracted from hair follicles collected from the tail of 196 females. Three SNPs were identified in DGAT1 gene by sequencing. Statistical analyses were performed to verify the linkage and the association between polymorphisms and traits. The estimated value of r (2) between two SNPs in exon 17 (g.11,783G > A and g.11,785 T > C) was 0.029. SNP g.11,785 T > C was significantly associated (P < 0.05) to fat and protein percentage. Dominance effect was significant for milk and fat yields and protein percentage (P < 0.05). The additive effect of the SNP g.11,785 T > C was significant for protein production and somatic cell count (P < 0.05). It indicates that assisted marker selection might be done with considerations to balance production and udder health.

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Section: Introductionmentioning

confidence: 99%

Genetic association between SNPs in the DGAT1 gene and milk production traits in Murrah buffaloes

Freitas

Camargo

Stafuzza

et al. 2016

Trop Anim Health Prod

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“…The allele frequencies of the two SNPs at the DGAT1 gene in three buffalo breeds are given in online Supplementary Table S2. Mishra et al (2007) reported 13 SNPs by comparing the DGAT1 exons sequences of the Chinese buffalo (2n = 48) and Indian buffalo (2n = 50), which may due to the difference in the genetic evolution of the DGAT1 in the Riverine buffalo and the swamp buffalo. Moreover, all three buffalo groups shared the same K genotype with K232A mutation in the 8th exon of DGAT1 , which is a well-recognized mutation related to milk fat and protein percentages (Spelman et al 2002; Naslund et al 2008).…”

Section: Resultsmentioning

confidence: 99%

DGAT1 polymorphism in Riverine buffalo, Swamp buffalo and crossbred buffalo

Liu

et al. 2018

Journal of Dairy Research

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This Research Communication describes the polymorphisms in the coding region of DGAT1 gene in Riverine buffalo, Swamp buffalo and crossbred buffalo, and associations between polymorphisms and milk production performance in Riverine buffalo. Two polymorphisms of DGAT1were identified, located in exon 13 and exon 17, respectively. The distribution of the genotypes of the two SNP loci in different buffalo population varied, especially the polymorphism located in exon 13 which was not found in the Swamp buffalo. Moreover, SNP located in exon 17 was a nonsynonymous switch resulting in the animo acid sequence changed from an arginine (Arg) to a histidine (His) at position 484. Both SNPs were in Hardy-Weinberg equilibrium, and the polymorphism of g.8330T>C in the exon 13 was significantly associated with peak milk yield, total milk yield and protein percentage. The C variant was associated with an increase in milk yield and peak yield but less in protein percentage compared with the T variant. The polymorphisms of g.9046T>C in exon 17 were significantly associated with fat percentage, in that the buffaloes with TT genotype had a significantly higher fat percentage than those with CC genotype. These findings reveal the difference in the genetic evolution of the DGAT1 between Riverine buffalo and Swamp buffalo, and provide evidence that the DGAT1 gene has potential effects for Riverine buffalo milk production traits, which can be used as a candidate gene for marker-assisted selection in buffalo breeding.

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“…Buffalo play an important role in the rural economy of developing countries. In addition to the utility of these animals for milk and meat production, their adaptation to natural conditions and tolerance to diseases makes them economically advantageous (Aytekin et al, 2011;Mishra et al, 2007;Yilmaz et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Buffalo genetic resources are depleting and the loss of some genotypes may jeopardize the continuation of the species (Aytekin et al, 2011;Gargani et al, 2009;Mishra et al, 2007;Soysal et al, 2005;Yilmaz et al, 2011). For this reason, the Anatolian Water Buffalo are involved in a protection program of gene resources with the declaration of guidelines for subsidizing animal farming (Prescript no: 2006/9) by the Ministry of Agriculture and Rural Affairs in Turkey.…”

Section: Introductionmentioning

confidence: 99%