Characterization of the complete mitochondrial genome and phylogenetic analysis of Prototheca stagnorum (chlorellales: Chlorellaceae)

Abstract

Prototheca stagnorum belongs to the genus Prototheca that are achloroplyllous algae with phylogenetic affinities to Chlorella sp. Microalgae of the genus Prototheca spp are associated with rare algal infections of invertebrates termed protothecosis. In this study, the complete nucleotide sequence of the circular mitochondrial (mt) DNA of the chlorophyte alga P. stagnorum has been determined (80,023 base-pairs, A þ T content 13.77%). The genes identified encode three subunits of the cytochrome oxidase and apocytochrome b, eight subunits of the NADH dehydrogenase complex (nad1-7, nad4L), four ATPase subunits (atp1, atp4, atp6, atp8), three ribosomal RNAs (5 S (rrn5), small subunit (srn) and large subunit (lrn) RNA), 27 tRNAs, two succinate dehydrogenase and 10 ribosome proteins. The complete mitochondrial genome sequence will provide new molecular biology information to further understand the genetic diversity of the Prototheca sp. and to eliminate this population.

Hsa_hsa_circ_0081069 promotes the progression of colorectal cancer through sponging miR‐665 and regulating E2F3 expression

“…CircRNAs are widely expressed in eukaryotic cells and implicated in the regulation of different biological processes 28–30 . Accumulating evidence indicate that the deregulation of circRNAs contributes to the tumor initiation and progression 31–33 . For example, Chen et al showed that has_circ_101555 promotes the proliferation and progression of CRC via regulating miR‐597‐5p/CDK6 axis 34 .…”

“…[28][29][30] Accumulating evidence indicate that the deregulation of circRNAs contributes to the tumor initiation and progression. [31][32][33] For example, Chen et al…”

“… 28 , 29 , 30 Accumulating evidence indicate that the deregulation of circRNAs contributes to the tumor initiation and progression. 31 , 32 , 33 For example, Chen et al showed that has_circ_101555 promotes the proliferation and progression of CRC via regulating miR‐597‐5p/CDK6 axis. 34 In addition, Xie et al demonstrated that has_circ_001569 acts as a sponge of miR‐145 to suppress the progression of CRC in vivo.…”